Houston Methodist. Leading Medicine.
Houston Methodist. Leading Medicine

Ericka Simpson, M.D.

Ericka Simpson, M.D.


Ericka Simpson, M.D.

Ericka Simpson, M.D.

Assistant Member
The Methodist Hospital Research Institute
Director, ALS Clinical Research Division
Co-Director, MDA Neuromuscular Clinic
Director, Myesthenia Gravis Clinic
Methodist Neurological Institute
Director, Neurology Residendy Program
The Methodist Hospital
Assistant Professor of Neurology
Weill Cornell Medical College of Cornell University

Phone: 713-441-3336
Fax: 713-790-5079


B.A.  Rice University, Houston, Texas
M.D. The University of Texas Medical School at Houston, Houston, Texas

Postdoctoral Training

Internship, Department of Medicine, Baylor College of Medicine, Houston, Texas
Neurology Residency, Baylor College of Medicine, Houston, Texas
Neuroscience Fellowship, Baylor College of Medicine, Houston, Texas
Physician Scientist Fellowhip, Baylor College of Medicine, Houston, Texas



While completing her postdoctoral training, Dr. Simpson studied under the renowned Dr. Stanley Appel, the current chair of the Department of Neurology at The Methodist Hospital and the founder of the Methodist Neurological Institute. After completion of a fellowship in Dr. Appel’s laboratory, she became a tenure track Assistant Professor of Neurology at the Baylor College of Medicine in Houston, Texas. Dr. Simpson is a member of the American Academy of Neurology, the American Board of Psychiatry and Neurology, and a recipient of the Robert Wood Johnson Foundation’s Minority Medical Faculty Development Program. She joined the Methodist Hospital Physician Organization in 2005.

Description of Research

Dr. Simpson’s research aims to characterize the peripheral immune inflammatory response in ALS and other neurodegenerative diseases, and identify the potential markers that may reflect disease activity and progression. Her translational research seeks to identify and develop effective therapies that positively alter the natural progression of these diseases. Dr. Simpson’s research has demonstrated an apparent overreaction of the microglia cells that surround the motor neurons, thus providing a potential therapy in the form of homologous bone marrow-derived stem cell transplants.

Major Areas of Research

Neurology, ALS, biomarkers, dendritic cells, MCP-1, microglia, stem cells.

Recent Publications

Jawaid A, Salamone AR, Strutt AM, Murthy SB, Wheaton M, McDowell EJ, Simpson E, Appel SH, York MK, Schulz PE. ALS disease onset may occur later in patients with pre-morbid diabetes mellitus. Eur J Neurol. 2010 Jan 13. [Epub ahead of print]

Cudkowicz ME, Katz J, Moore DH, O'neill G, Glass JD, Mitsumoto H, Appel S, Ravina B, Kieburtz K, Shoulson I, Kaufmann P, Khan J, Simpson E, Shefner J, Levin B, Cwik V, Schoenfeld D, Aggarwal S, McDermott MP, Miller RG. Toward more efficient clinical trials for amyotrophic lateral sclerosis. Amyotroph Lateral Scler. 2009 Dec 4. [Epub ahead of print]

Sterling LE, Jawaid A, Salamone AR, Murthy SB, Mosnik DM, McDowell E, Wheaton M, Strutt AM, Simpson E, Appel S, Schulz PE. Association between dysarthria and cognitive impairment in ALS: A prospective study. Amyotroph Lateral Scler. 2009 Aug 31:1-6.

Castrillo-Viguera C, Grasso DL, Simpson E, Shefner J, Cudkowicz ME. Clinical significance in the change of decline in ALSFRS-R. Amyotroph Lateral Scler. 2009 Jul 26:1-3.

Sorenson EJ, Windbank AJ, Mandrekar JN, Bamlet WR, Appel SH, Armon C, Barkhaus PE, Bosch P, Boylan K, David WS, Feldman E, Glass J, Gutmann L, Katz J, King W, Luciano CA, McCluskey LF, Nash S, Newman DS, Pascuzzi RM, Pioro E, Sams LJ, Scelsa S, Simpson EP, Subramony SH, Tiryaki E, Thornton CA. Subcutaneous IGF-1 is not beneficial in 2-year ALS trial. Neurology. 2008 Nov 25;71(22):1770-5.

Appel SH, Engelhardt JI, Henkel JS, Siklos L, Beers DR, Yen AA, Simpson EP, Luo Y, Carrum G, Heslop HE, Brenner MK, Popat U. Hematopoietic stem cell transplantation in patients with sporadic amyotrophic lateral sclerosis. Neurology. 2008 Oct 21;71(17):1326-34.

Dunckley T, Huentelman MJ, Craig DW, Pearson JV, Szelinger S, Joshipura K, Halperin RF, Stamper C, Jensen KR, Letizia D, Hesterlee SE, Pestronk A, Levine T, Bertorini T, Graves MC, Mozaffar T, Jackson CE, Bosch P, McVey A, Dick A, Barohn R, Lomen-Hoerth C, Rosenfeld J, O'connor DT, Zhang K, Crook R, Ryberg H, Hutton M, Katz J, Simpson EP, Mitsumoto H, Bowser R, Miller RG, Appel SH, Stephan DA. Whole-genome analysis of sporadic amyotrophic lateral sclerosis. N Engl J Med. 2007 Aug 23;357(8):775-88.

Czaplinski A, Haverkamp LJ, Yen AA, Simpson EP, Lai EC, Appel SH. The value of database controls in pilot or futility studies in ALS. Neurology. 2006 Nov 28;67(10):1827-32.

Czaplinski A, Yen AA, Simpson EP, Appel SH. Predictability of disease progression in amyotrophic lateral sclerosis. Muscle Nerve. 2006 Dec;34(6):702-8.