Houston Methodist. Leading Medicine.
Houston Methodist. Leading Medicine

Kelvin K. Wong, Ph.D.

Kelvin K. Wong, Ph.D.

Kelvin K. Wong, Ph.D.

Associate Research Member
Director, Translational Multimodality Optical Imaging Laboratory
Director, Neuroimaging MRI Research,
TT and WF Chao Center for BRAIN
Department of Systems Medicine and Bioengineering
Houston Methodist Research Institute

Research Scientist, Department of Radiology,
Houston Methodist Hospital

Assistant Professor of Electronic Engineering in Radiology
Weill Cornell Medical College of Cornell University
Adjunct Assistant Professor of Pediatrics in Hematology and Oncology
Baylor College of Medicine

Phone: 713-441-8694
E-mail: kwong@houstonmethodist.org


B. Eng Electrical & Electronic Eng., University of Hong Kong, Hong Kong
M. Phil Electrical & Electronic Eng., University of Hong Kong, Hong Kong
Ph.D. Electrical & Electronic Eng., University of Hong Kong, Hong Kong

Postdoctoral Training

Postdoctoral Fellow, HCNR Center of Bioinformatics, Harvard Medical School, Boston, MA



Dr. Wong is a biomedical engineer who specializes in developing new imaging systems for the visualization of human disease. He received his Magnetic Resonance (MR) physics training at Columbia University in New York City, and in 2005, he joined the Functional and Molecular Imaging Center of the Brigham and Women’s Hospital and the HCNR Center of Bioinformatics in the Harvard Medical School as a Postdoctoral Fellow. In 2007, he left Harvard and joined the Methodist Hospital Research Institute to direct the Translational Multimodality Optical Imaging laboratory.

Description of Research

Dr. Wong’s current research interests focus on clinical and preclinical MR imaging research. In addition to establishing the advanced neuroimaging capabilities at TT and WF Chao Center for BRAIN for neurological disorders, his laboratory focuses on image-guided optical imaging for cellular and molecular imaging for glioblastoma and lung cancer diagnosis. He also combines his expertise in small animal MRI and optical imaging to investigate the tumor vasculature microenvironment using multimodality multiscale image-based modeling. His current projects include:

  • Image Guided Optical Molecular Imaging in Lung Cancer Diagnosis
  • MR Perfusion derived Tissue Residual Function Analysis of Glioblastoma undergoing Anti-angiogenic/Anti-vascular Therapy
  • Multimodailty Multiscale Image-based Modeling of Glioblastoma

Major Areas of Research

cancer imaging, image-guided intervention, molecular imaging

Recent Publications

He T, Xue Z, Alvarado MV, Wong KK, Xie W, Wong ST. Nonlinear motion compensation using cubature Kalman filter for in vivo fluorescence microendoscopy in peripheral lung cancer intervention. J Biomed Opt. 2013 Jan;18(1):16008. PMID: 23291716

Zhang G, Zhang R, Melancon MP, Wong K, You J, Huang Q, Bankson J, Liang D, Li C. The degradation and clearance of Poly(N-hydroxypropyl-l-glutamine)-DTPA-Gd as a blood pool MRI contrast agent. Biomaterials. 2012 Jul;33(21):5376-83.

He T, Xue Z, Lu K, Valdivia Y Alvarado M, Wong KK, Xie W, Wong ST. A minimally invasive multimodality image-guided (MIMIG) system for peripheral lung cancer intervention and diagnosis. Comput Med Imaging Graph. 2012 Jul;36(5):345-55.

Chen T, Xue Z, Wang C, Qu Z, Wong KK, Wong ST. Motion correction for cellular-resolution multi-photon fluorescence microscopy imaging of awake head-restrained mice using speed embedded HMM. Comput Med Imaging Graph. 2012 Apr;36(3):171-82.

Valdivia Y Alvarado M, Wong K*, Cheng He T, Xue Z, Wong ST. Image-guided fiberoptic molecular imaging in a VX2 rabbit lung tumor model. J Vasc Interv Radiol. 2011 Dec;22(12):1758-64.

Gao L, Li F, Thrall MJ, Yang Y, Xing J, Hammoudi AA, Zhao H, Massoud Y, Cagle PT, Fan Y, Wong KK, Wang Z, Wong ST. On-the-spot lung cancer differential diagnosis by label-free, molecular vibrational imaging and knowledge-based classification. J Biomed Opt. 2011 Sep;16(9):096004.

Wong K, Young GS, Makale M, Hu X, Yildirim N, Cui K, Wong ST, Kesari S. Characterization of a human tumorsphere glioma orthotopic model using magnetic resonance imaging. J Neurooncol. 2011 Sep;104(2):473-81.

Hu X, Wong KK*, Young GS, Guo L, Wong ST. Support vector machine (SVM) multi-parametric MRI identification of pseudoprogression from tumor recurrence in patients with resected glioblastoma. J Magn Reson Imaging. 2011 Feb;33(2):296-305.

Wang Z, Liu Y, Gao L, Chen Y, Luo P, Wong KK, Wong ST. Use of multimode optical fibers for fiber-based coherent anti-Stokes Raman scattering microendoscopy imaging. Opt Lett. 2011 Aug 1;36(15):2967-9.

Wang Z, Gao L, Luo P, Yang Y, Hammoudi AA, Wong KK, Wong ST. Coherent anti-Stokes Raman scattering microscopy imaging with suppression of four-wave mixing in optical fibers. Opt Express. 2011 Apr 25;19(9):7960-70.

Gao L, Zhou H, Thrall MJ, Li F, Yang Y, Wang Z, Luo P, Wong KK, Palapattu GS, Wong ST. Label-free high-resolution imaging of prostate glands and cavernous nerves using coherent anti-Stokes Raman scattering microscopy. Biomed Opt Express. 2011 Mar 18;2(4):915-26.

Yang Y, Li F, Gao L, Wang Z, Thrall MJ, Shen SS, Wong KK, Wong ST. Differential diagnosis of breast cancer using quantitative, label-free and molecular vibrational imaging. Biomed Opt Express. 2011 Aug 1;2(8):2160-74.

Mok V, Wong KK, Xiong Y, Wong A, Schmidt R, Chu W, Hu X, Leung EYL, Cheng S, Cheng Y, Tang WK, Cheng X, Ho CL, Wong KS, Wong S. Cortical and Frontal Atrophy are associated with Cognitive Impairment in Age-Related Confluent White Matter Lesion. J Neurol Neurosurg Psychiatry. 2011 Jan;82(1):52-7.

Tang AM, Ananta JS, Zhao H, Cisneros BT, Lam EY, Wong STC, Wilson LJ, Wong KK*. Cellular Uptake and Imaging Studies of Gadolinium-loaded Single-Walled Carbon Nanotubes as MRI Contrast Agents. Contrast Media Mol Imaging. 2011 Mar-Apr;6(2):93-9.

Mok V, Wong A, Wong KK, Chu WCW, Xiong Y, Chan YY, Kwok TCY, Hu X, Lee WK, Tang WK, Wong KS, Wong S. Executive dysfunction and left frontal white matter hyperintensities (WMH) are correlated with neuropsychiatric symptoms in stroke patients with confluent WMH. Dement Geriatr Cogn Disord. 2010;30(3):254-60.

Wong KK*. Tam C. Ng M. Accurate vascular delay estimation from low temporal resolution image dataset. IEEE Signal Process Mag. 2010; 27, 155-158.

Wang Z, Yang Y, Luo P, Gao L, Wong KK, Wong STC. Delivery of picosecond lasers in multimode fibers for coherent anti-Stokes Raman scattering imaging. Optics Express. 2010; 18(12):13017-13028.

Xue Z, Wong KK, Wong ST. Joint Registration and Segmentation of Serial Lung CT Images for Image-Guided Lung Cancer Diagnosis and Therapy. Comput Med Imaging Graph. 2010 Jan;34(1):55-60.

Liao H, Wong KK, Xue Z. Editorial: Introduction to the special issue of image-guided surgical planning and therapy. Comput Med Imaging Graph. 2010 Jan;34(1):1-2.

Fu JH, Wong KK, Mok V, Hu X, Xiong Y, Chen Y, Tang WK, Chen X, Wong A, Chu W, Wong KS, Wong S. Neuroimaging predictors for depressive symptoms in cerebral small vessel disease. Int J Geriatr Psychiatry. 2010 Oct;25(10):1039-43.

Ananta JS, Matson ML, Tang AM, Mandal T, Lin S, Wong KK, Wong ST, Wilson LJ. Single-Walled Carbon Nanotube Materials as T2-Weighted MRI Contrast Agents. J. Phys. Chem. C. 2009, 113 (45), 19369–19372.

Wong KK*, Tam CP, Ng M, Wong ST, Young GS. Improved residue function and reduced flow dependence in MR perfusion using least-absolute-deviation regularization. Magn Reson Med. 2009 Feb;61(2):418-28.

Kwong KK, Kloetzer L, Wong KK, Ren JQ, Kuo B, Jiang, Y, Chen YI, Chan ST, Young GS, Wong ST. Bioluminescence imaging of heme oxygenase-1 upregulation in the Gua Sha procedure. J Vis Exp. 2009 Aug 28;(30). pii: 1385. doi: 10.3791/1385.

Zhao H, Zhu J, Cui K, Xu X, O'Brien M, Wong KK, Kesari S, Xia W, Wong ST. Bioluminescence imaging reveals inhibition of tumor cell proliferation by Alzheimer's amyloid beta protein. Cancer Cell Int. 2009 Jun 1;9(1):15.

Tang AM, Kacher DF, Lam EY, Wong KK, Jolesz FA, Yang ES, Simultaneous Ultrasound and MRI System for Breast Biopsy: Compatibility Assessment and Demonstration in a Dual Modality Phantom. IEEE Tran of Medical Imaging. 2008 Fe;27(2):247-54.

Wong KK, Yang ES, Wu EX, Tse HF, Wong STC. First-pass myocardial perfusion image registration by maximization of normalized mutual information. J Magn Reson Imaging. 2008 Mar;27(3):529-37.

Liu T, H Li, Wong KK, Tarokh A, Lei G, Wong ST. Brain Tissue Segmentation Based on DTI Data. Neuroimage. 2007 Oct 15;38(1):114-23.