Geoffrey A. Land, Ph.D., H.C.L.D.
NIH Research Fellowship, Department of Microbiology, Duke University Medical Center, Durham NC
Dr. Land is both an immunologist and microbiologist with special interests in human major histocompatibility antigens and alleles, transplant Immunology, opportunistic infections, mycobacteria, and medical mycology. Dr. Land is currently director of Histocompatibility and Transplant Immunology and co-director of Microbiology at Houston Methodist Hospital, and director of Histocompatibility at the Stewart Regional Blood Center in Tyler, Texas. Dr. Land serves on several state and national organ allocation committees, including the Texas Tissue and Organ Donor Advisory Council and the UNOS Histocompatibility and Minority Committees. Dr. Land is an editor for the Journal of Clinical Microbiology, and Archives of Pathology and Laboratory Medicine. He joined Houston Methodist in 2004 after serving for more than 20 years as the director of both the Microbiology and Immunology program and Immunohistochemistry Laboratory at the Methodist Medical Center in Dallas, Texas.
In addition to his research and administrative duties, Dr. Land is actively involved in quality assurance and the standardization of histocompatibility laboratory procedures and practices. He is an active laboratory inspector, serving on the Accreditation Review Board as commissioner (2 terms), co-chair, and program director, and as a co-editor of the American Society for Histocompatibility and Immunogenetics (ASHI) laboratory manual. He also serves as a member of the IRB and chair of the IBC committee for Houston Methodist Research Institute.
Dr. Land´s research interests are both clinical and translational in nature and include developing rapid methods for human histocompatibility crossmatching, transplantation of highly sensitized patients, and direct rapid phenotypic or molecular methods for species identification of mycobacteria and fungi and for human histocompatibility typing. These projects utilize SSP-PCR, RT-PCR, DNA sequencing, flow cytometry, and solid phase multi-channel arrays. Dr. Land´s current research interests in the area of transplant immunology are focused on T and B cell immunomodulation in short and long-term allograft survival in solid organ recipients, and the clinical relevance of low-level HLA and non-HLA antibodies in short and long term allograft survival. He is also involved in the identification of molecular markers of the human major histocompatibility complex and presence of cytokine alleles as predictor(s) of rejection in solid organ recipients. His laboratory specializes in sequenced-based typing of human histocompatibility alleles, monitoring engraftment, and developing protocols to detect maternal microchimerism in offspring requiring stem cell transplant.
Dr. Land´s research interests in microbiology include determining the underlying molecular mechanism(s) that control morphogenic shifts in polymorphic fungi and developing rapid sequence-based tools and other molecular methods to diagnose microbial, fungal, and viral infections from direct specimens. New sequenced-based tools allow for rapid identification of the pathogen leading to specific and timely treatment for the patient. Dr. Land is also developing a computer model to identify opportunistic infections by determining the relationship between certain microbial adhesion/attachment molecules with specific major human histocompatibility receptors.
histocompatibility, transplant immunology, HLA typing, allograft survival, mycobacteria
Nikaein A, Cherikh W, Nelson K, Baker T, Leffell S, Bow L, Crowe D, Connick K, Head MA, Kamoun M, Kimball P, Klohe E, Noreen H, Rebellato L, Sell T, Sullivan K, Land G. Organ procurement and transplantation network/united network for organ sharing histocompatibility committee collaborative study to evaluate prediction of crossmatch results in highly sensitized patients. Transplantation. 2009 Feb 27;87(4):557-62.
Raghavan R, Jeroudi A, Achkar K, Suki W, Gaber AO, Knight R, Land G, Dilioglou S, Patel S, Abdellatif A. Bortezomib in kidney transplant desensitization: a case report. Clin Transpl. 2009:339-42.
Olsen RJ, Cernoch PA, Austin CM, Graviss EA, Farkas DH, Land GA. Validation of the MycoAlign system for Mycobacterium spp. identification. Diagn Microbiol Infect Dis. 2007 Sep;59(1):105-8.
Olsen RJ, Cernoch PL, Land GA. Mycobacterial synovitis caused by slow-growing nonchromogenic species: eighteen cases and a review of the literature. Arch Pathol Lab Med. 2006 Jun;130(6):783-91.