Stephen Wong, Ph.D., P.E.
Director of Translational Research
Japan Program Fellow, National Science Foundation, ICOT, The Fifth Generation Computer Systems Project, MITI, Tokyo, Japan
Dr. Wong is the Founding Chairman for Department of Systems Medicine and Bioengineering, Houston Methodist Research Institute. He holds the John S. Dunn, Sr. Distinguished Endowed Chair in Biomedical Engineering; he is also a Professor of Radiology, Pathology, Laboratory Medicine, Neurology, and Neurosciences, the Associate Director of Translational Research at Methodist Cancer Center, and Chief of Medical Physics and Chief Research Information Officer at Houston Methodist Hospital. In addition, he serves as the Founding Director of the Ting Tsung and Wei Fong Chao Center for BRAIN (Bioinformatics Research and Imaging in the Neurosciences) and Founding Director of the Center for Modeling Cancer Development at Houston Methodist Research Institute. He also holds a dozen of other academic posts across institutions in Texas Medical Center as well as overseas universities and medical schools. An internationally acclaimed bioengineer and imaging scientist, Dr. Stephen Wong has led teams that developed production automation for first very large scale integration (VLSI) 1MB computer memory chip and the largest online brokerage trading system, and contributed to the first hospital-wide digital radiology image management system in US academic medical centers.
Dr. Wong has more than twenty years of research and management experience in industry and academia, including Hewlett-Packard, AT&T Bell Laboratories, the Japanese Fifth Generation Computer Systems Project, Philips Medical Systems and Royal Philips Electronics, Charles Schwab, University of California - San Francisco/Berkeley, Harvard University and The Methodist Hospital. He received his senior executive education from the MIT Sloan School of Management, Stanford University Graduate School of Business and Columbia University Graduate School of Business. He holds eight patents and has published over 300 peer-reviewed papers and four books. He also serves on and chairs NIH study panels, conference program committees, and the editorial boards of twelve scientific journals. As an international authority, he is sought as a speaker on medical imaging, systems biology, healthcare IT, drug development, biophotonics, clinical neuroscience and other related topics.
Dr. Wong's research focuses on understanding health and disease from a systems perspective in order to generate cost-effective strategies and solutions for disease management. His research approaches combine both experimental and high throughput biology with rigorous computational, bioinformatics, biophysics, and imaging methods to achieve a deep understanding of the functions of each component in biological systems and integration of them with multilevel systems analysis. For example, the consequences of genetic variation, cell-cell interactions and environmental factors are included to reflect the circumstances and microenvironments of the disease condition. Current research projects include pathway modeling and high throughput phenotyping approaches for target discovery and drug repurposing in combating neurological disorders and cancer, and for understanding the mechanisms of these diseases. Additional projects include reformulation of small molecule drugs using chemical biology approaches, the development of point-of-care molecular diagnosis and monitoring devices using biophotonics and nanotechnology techniques, and the development of label-free molecular image-guided cancer therapy platforms.
Biological and medical imaging, bioinformatics and systems biology, drug repositioning and combinations, image-guided therapy, translational biophotonics, molecular imaging and diagnosis, and mechanisms of cancer and neurological disorders.
Li H, Xue Z, Ellmore TM, Frye RE, Wong ST. Network-based analysis reveals stronger local diffusion-based connectivity and different correlations with oral language skills in brains of children with high functioning autism spectrum disorders. Hum Brain Mapp. 2014 Feb;35(2):396-413. PMID: 23008187
Jin G, Wong ST. Toward better drug repositioning: Prioritizing and integrating existing methods into efficient pipelines. Drug Discov Today. 2013 Nov 14. PMID: 24239728
Zhao H, Jin G, Cui K, Ren D, Liu T, Chen P, Wong S, Li F, Fan Y, Rodriguez A, Chang J, Wong ST. Novel modeling of cancer cell signaling pathways enables systematic drug repositioning for distinct breast cancer metastases. Cancer Res. 2013 Oct 15;73(20):6149-63. PMID: 24097821
Glasgow SM, Laug D, Brawley VS, Zhang Z, Corder A, Yin Z, Wong ST, Li XN, Foster AE, Ahmed N, Deneen B. The miR-223/Nuclear Factor I-A Axis Regulates Glial Precursor Proliferation and Tumorigenesis in the CNS. J Neurosci. 2013 Aug 14;33(33):13560-13568. PMID: 23946414
Yin Z, Sadok A, Sailem H, McCarthy A, Xia X, Li F, Garcia MA, Evans L, Barr AR, Perrimon N, Marshall CJ, Wong ST, Bakal C. A screen for morphological complexity identifies regulators of switch-like transitions between discrete cell shapes. Nat Cell Biol. 2013 Jul;15(7):860-71. PMID: 23748611
Deng T, Lyon CJ, Minze LJ, Lin J, Zou J, Liu JZ, Ren Y, Yin Z, Hamilton DJ, Reardon PR, Sherman V, Wang HY, Phillips KJ, Webb P, Wong ST, Wang RF, Hsueh WA. Class II Major Histocompatibility Complex Plays an Essential Role in Obesity-Induced Adipose Inflammation. Cell Metab. 2013 Mar 5;17(3):411-22. PMID: 23473035
Li F, Yin Z, Jin G, Zhao H, Wong ST. Bioimage Informatics for Systems Pharmacology. PLoS Comput Biol. 2013 Apr;9(4):e1003043. PMID: 23633943
Mancuso JJ, Chen Y, Li X, Xue Z, Wong ST. Methods of Dendritic Spine Detection: from Golgi to High Resolution Optical Imaging. Neuroscience. 2013 Oct 22;251:129-40. PMID: 22522468
Gao D, Vahdat LT, Wong S, Chang JC, Mittal V. Microenvironmental regulation of epithelial-mesenchymal transitions in cancer. Cancer Res. 2012 Oct 1;72(19):4883-9. PMID: 23002209
Fan J, Xia X, Li Y, Dy JG, Wong ST. A quantitative analytic pipeline for evaluating neuronal activities by high throughput synaptic vesicle imaging. Neuroimage. 2012 Sep;62(3):2040-54. PMID: 22732566
Xia X, Wong ST. A High-Content Screening Approach to Stem Cell Research and Drug Discovery. Stem Cells. 2012 Sep;30(9):1800-7. PMID: 22821636
Xia W, Wong ST, Hanlon E, Morin P. γ-Secretase Modulator in Alzheimer's Disease: Shifting the End. J Alzheimers Dis. 2012 Jan 1;31(4):685-96. PMID: 22710916
Zhao H, Cui K, Nie F, Wang L, Brandl MB, Jin G, Li F, Mao Y, Xue Z, Rodriguez A, Chang J, Wong ST. The effect of mTOR inhibition alone or combined with MEK inhibitors on brain metastasis: an in vivo analysis in triple-negative breast cancer models. Breast Cancer Res Treat. 2012 Jan;131(2):425-36. PMID: 21394501
Jin G, Fu C, Zhao H, Cui K, Chang J, Wong ST. A novel method of transcriptional response analysis to facilitate drug repositioning for cancer therapy. Cancer Res. 2012 Jan 1;72(1):33-44. PMID: 22108825
Gao L, Hammoudi AA, Li F, Thrall MJ, Cagle PT, Chen Y, Yang J, Xia X, Fan Y, Massoud Y, Wang Z, Wong ST. Differential diagnosis of lung carcinoma with three-dimensional quantitative molecular vibrational imaging. J Biomed Opt. 2012 Jun;17(6):066017. PMID: 22734773
Mok V, Xiong Y, Wong KK, Wong A, Schmidt R, Chu WW, Hu X, Lung Leung EY, Chen S, Chen Y, Tang WK, Chen X, Ho CL, Wong KS, Wong ST. Predictors for cognitive decline in patients with confluent white matter hyperintensities. Alzheimers Dement. 2012 Oct;8(5 Suppl):S96-S103. PMID: 22651941