Houston Methodist. Leading Medicine.
Houston Methodist. Leading Medicine

Santosh Aryal

Santosh Aryal, Ph.D.

Santosh Aryal, Ph.D.

Santosh Aryal, Ph.D.

Research Associate II
The Methodist Hospital Research Institute

E-mail: saryal@houstonmethodist.org


B.S.   Chemistry and Biology, Tribhuvan University, Nepal
M.S.   Chemistry, Tribhuvan University, Nepal
Ph.D.   Bionanosystem Engineering, Chonbuk National University, Jeonju, South Korea


Dr. Santosh Aryal received his Ph.D. in Bionanosystem Engineering from Chonbuk National University, Jeonju, South Korea, in 2007 under the supervision of Prof. Kim Hak Yong. Following one year of postdoctoral training at Chonbuk National University and the University of Wisconsin, Milwaukee, he joined the department of Nanoengineering at the Moores Cancer Center as a Postdoc and immediately promoted to Asst. Project Scientist. He joined the Department of Nanomedicine at Methodist Hospital as a Research Associate II in July 2012.

Description of Research

Dr. Aryal’s research seeks to address the challenges in nanomedicine such as circulation of nanoparticles, targeting efficiency, pharmacokinetics, drug resistance, loading efficiency, biocompatibility, and control of size and porosity in order to enhance the therapeutic effect.

Major Areas of Research

  • Combinatorial drug delivery system.
  • Polymer synthesis and characterization.
  • Synthesis, characterization, and biomedical evaluation of polymeric, liposomal, metal, and lipid-polymer hybrid nanoparticles.
  • Synthesis, characterization, and biomedical evaluation of polymer-drug conjugates.
  • Synthesis and characterization of small molecules.

Recent Publications

Aryal S., Hu C. M., Zhang L. Synthesis of Ptsome: a platinum-based liposome-like nanostructure. Chem. Commun. (2012) 48, 2630.

Aryal S., Hu C. M., Zhang L. Nanoparticle drug delivery enhances the toxicity of hydrophobic-hydrophilic drug conjugates. Journal of Materials Chemistry (2012) 22, 949.

Aryal S., Hu C. M., Zhang L. Polymeric nanoparticles with precise ratiometric control over drug loading for combination therapy. Molecular Pharmaceutics (2011) 8, 1401.

Hu C. M., Zhang L., Aryal S., Cheung C., Fang R., Zhang L. Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform. Proceedings of the National Academy of Science (PNAS) (2011) 108, 10980.

Clawson, C., Ton, L., Aryal, S., Fu, V., Esener, S., Zhang, L. Synthesis and characterization of lipid-polymer hybrid nanoparticles with pH-triggered PEG shedding. Langmuir 2011, 27, 10556.

Pornpattananangkul, D., Zhang, L., Olson, S., Aryal S., Obonyo, M., Vecchio, K., Huang, C-M., Zhang, L. Bacterial toxin-triggered drug release from gold nanoparticle-stabilized liposomes for the treatment of bacterial infection. Journal of the American Chemical Society (JACS) (2011) 133, 4132.

Aryal S., Hu C. M., Zhang L. Combinatorial drug conjugation enabled nanoparticle dual drug delivery, Small (2010) 6, 1442.

Aryal S., Hu C. M., Zhang L. Polymer-cisplatin conjugate nanoparticles for acid-responsive drug delivery. ACS Nano (2010) 4, 251.

Hu C. M., Aryal S., Zhang L. Nanoparticles assisted combination therapies for effective cancer treatment. Therapeutic Delivery (2010) 1, 323.

Fang R., Aryal S., Hu C-M., Zhang L. Quick synthesis of lipid-polymer hybrid nanoparticles with low polydispersity using a single-step sonication method. Langmuir (2010) 26, 16958