Houston Methodist. Leading Medicine.
Houston Methodist. Leading Medicine

Methodist J.C. Walter Jr. Transplant Center - Houston, TX

Edward Rhee, M.D.

Roberto Barrios, M.D.

Roberto Barrios, M.D.


Clinical Expertise

  • Pulmonary and Renal Pathology

Selected Professional Activity

  • Senior Member
  • Houston Methodist Research Institute
  • Staff Pathologist
  • Department of Pathology and Genomic Medicine
  • The Methodist Hospital Physician Organization
  • Professor of Pathology and Laboratory Medicine
  • Weill Cornell Medical College of Cornell University

Research Interest

Dr. Barrios has worked with experimental pathology projects for the last twenty years, while at the same time his primary area of interest in diagnostic pathology has been pulmonary and renal pathology. His current projects include the study of interstitial lung diseases and pulmonary neoplasms. His collaborations in experimental pathology are related to oncogenesis and oxygen toxicity.
Major Areas of Research

Recent Publications

  • Kadikoy H, Paolini M, Achkar K, Suki W, Gaber AO, Anwar N, Jeroudi A, Barrios R, Abdellatif A. Pulmonary alveolar proteinosis in a kidney transplant: a rare complication of sirolimus. Nephrol Dial Transplant. 2010 Aug;25(8):2795-8.
  • Shen J, Barrios RJ, Jaiswal AK. Inactivation of the quinone oxidoreductases NQO1 and NQO2 strongly elevates the incidence and multiplicity of chemically induced skin tumors. Cancer Res. 2010 Feb 1;70(3):1006-14.
  • Iskander K, Barrios RJ, Jaiswal AK. NRH:quinone oxidoreductase 2-deficient mice are highly susceptible to radiation-induced B-cell lymphomas. Clin Cancer Res. 2009 Mar 1;15(5):1534-42.
  • Iskander K, Barrios RJ, Jaiswal AK. Disruption of NAD(P)H:quinone oxidoreductase 1 gene in mice leads to radiation-induced myeloproliferative disease. Cancer Res. 2008 Oct 1;68(19):7915-22.
  • Matsukura M, Chu FF, Au M, Lu H, Chen J, Rietkerk S, Barrios R, Farley JD, Montaner JS, Montessori VC, Walker DC, Côté HC. Liver ultrastructural morphology and mitochondrial DNA levels in HIV/hepatitis C virus coinfection: no evidence of mitochondrial damage with highly active antiretroviral therapy. AIDS. 2008 Jun 19;22(10):1226-9.
  • Barrios RJ. Hypersensitivity pneumonitis: histopathology. Arch Pathol Lab Med. 2008 Feb;132(2):199-203. Review.
  • Kaplan-Lefko PJ, Sutherland BW, Evangelou AI, Hadsell DL, Barrios RJ, Foster BA, Demayo F, Greenberg NM. Enforced epithelial expression of IGF-1 causes hyperplastic prostate growth while negative selection is requisite for spontaneous metastogenesis. Oncogene. 2008 May 1;27(20):2868-76.
  • Adikesavan AK, Barrios R, Jaiswal AK. In vivo role of NAD(P)H:quinone oxidoreductase 1 in metabolic activation of mitomycin C and bone marrow cytotoxicity. Cancer Res. 2007 Sep 1;67(17):7966-71.
  • Truong LD, Barrios R, Adrogue HE, Gaber LW. Acute antibody-mediated rejection of renal transplant: pathogenetic and diagnostic considerations. Arch Pathol Lab Med. 2007 Aug;131(8):1200-8. Review.
  • Kwon KY, Ro JY, Singhal N, Killen DE, Sienko A, Allen TC, Zander DS, Barrios R, Haque A, Cagle PT. MUC4 expression in non-small cell lung carcinomas: relationship to tumor histology and patient survival. Arch Pathol Lab Med. 2007 Apr;131(4):593-8.


  • Centro Universitario Mexico, Mexico City, Mexico
  • Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico
    Postdoctoral Training
  • Residency, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, OH
  • Residency, Children’s Hospital IMAN
    Residency, National Heart Institute, Mexico
  • Fellowship, McGill University, Meakins Christie Laboratory (Pulmonary Pathology), Montreal, P.Q. Canada

Dr. Barrio's Biography

Dr. Barrios received his first academic appointment in 1978 at the Universidad Nacional Autonoma de Mexico as an Assistant Professor of Histology and Pathology in the Department of Chemistry. He became a full professor there in 1982. He was visiting professor from 1990 through 1992 in Dr. Michael Lieberman’s laboratory at the Baylor College of Medicine. Dr. Barrios joined the Baylor College of Medicine in 1992 as an Associate Professor in the Department of Pathology, where he led numerous conferences and lectures for medical students. He assumed his positions at the Houston Methodist Hospital in 2004.