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The-Laboratory-Report_Spring2014

THE LABORATORY REPORT Spring 2014 Page 6 New Chief Residents for 2014-2015 Are Announced Dr. Suzanne Powell, director of the Department’s residency program, announced that Drs. Jaclyn Jerz (PGY3) and Eric Salazar (PGY2) will serve as the 2014- 2015 Chief Residents. Dr. Lauren King will serve as the Chief Fellow. “I would like to thank our outgoing Chief Residents, Daniel Wimmer (PGY4) and Suzanne Crumley (PGY3), and our Chief Fellow, Dr. Angela Wright, for all their hard work and dedication this year. We have been most fortunate to have such talented individuals in these roles.” The Chiefs began serving in their new roles in March. Drs. Jerz, Salazar, and King Research Spotlight: KRAS Mutations are Linked to Lung Adenocarcinoma Invasiveness A team of pathologists from the Houston Methodist Hospital and Research Institute and Northwestern University has recently linked mutations in a wellknown Kirsten-RAS (KRAS) oncogene with invasive properties of peripheral lung adenocarcinoma. The study was led by Dr. Kirtee Raparia, who is featured in this issue’s “Where Are They Now?” spotlight, and included Dr. Philip Cagle as one of the co-authors. Despite extensive research efforts, the 5-year survival of patients diagnosed with lung cancer has remained around 12-17% since 1975. As with most cancers, lung cancer develops as the result of tissue cells accumulating sequential genetic and epigenetic alterations. Patients whose tumors harbor KRAS mutations represent a unique group of individuals who are typically heavy smokers, are unlikely to respond to tyrosine kinase inhibitor treatment, and have a poor overall survival. Dr. Raparia’s group analyzed 187 resected lung adenocarcinomas for the status of 12 known mutations in the KRAS oncogene. Their results showed a significant correlation between heavy smoking and the presence of KRAS mutations, as well as between the presence of pleural invasion in patients with KRAS mutant tumors. Dr. Raparia’s results confirm that clinicopathologic features of lung adenocarcinoma are defined by their molecular make-up, such as their oncogene status. The article, published in Archives of Pathology & Laboratory Medicine, can be found on the journal’s web page. Invasive peripheral lung adenocarcinoma. Houston Methodist St. Catherine Hospital is Evaluated by the Joint Commission Triggered by the change in hospital ownership, The Joint Commission conducted an inspection and survey of Houston Methodist St. Catherine’s Hospital in March. With a successful completion of this major hurdle, Dr. Thu Ngo, medical director of Laboratory Services at the Methodist West Hospital, would like to express his gratitude to his laboratory team. St. Catherine Hospital courtyard “Preparation for this survey was an incredible effort by our amazing West Houston Laboratory Director, Melody Peeples, her point-of-care specialist, Tina Benson, and the rest of their dedicated team. I am very proud of their work and their ability to prepare for the survey in a very short period of time. Please join me in congratulating them on this superb achievement!”


The-Laboratory-Report_Spring2014
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