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THE LABORATORY REPORT Fall 2014 Page 5 Dr. Adriana Rosato Awarded a Grant to Study Methicillin-Resistant Staphylococcus aureus Infections Dr. Adriana Rosato received a grant from the National Institute of Allergy and Infectious Diseases for her application titled “Molecular bases of DAP-resistance-mediated sensitization to beta-lactams in MRSA”. This study will evaluate molecular mechanisms associated with daptomycin (DAP) resistance in methicillin-resistant Staphylococcus aureus (MRSA) infections. MRSA infections pose a significant health risk because they occur both in the community and in healthcare settings, where they can induce infections of surgical sites, bacteremia, and form biofilms. Importantly, MRSA infections are difficult to treat because these bacteria are resistant to a vast majority of antibiotics. DAP is a relatively new antibiotic that was FDA-approved in 2003 for treatment of systemic and life-threatening infections caused by Gram-positive bacteria, including MRSA. However, DAP-resistant MRSA strains have been recently identified. Prior studies in Dr. Rosato’s laboratory identified several mechanisms of DAP resistance in previously-sensitive MRSA strains. Importantly, they also showed that these DAP-resistant bacteria become sensitive to oxacillin, a betalactam class of antibiotics, although the mechanism of this sensitization had not been identified. Studies proposed in this application will evaluate the molecular mechanisms underlying DAP resistance and oxacillin re-sensitization. Dr. Rosato is a research scientist in the Department of Pathology and Genomic Medicine at Houston Methodist Hospital and Associate Member of the Houston Methodist Research Institute. Prior to joining the Department in 2010, Dr. Rosato was Assistant Professor in the Department of Internal Medicine at Virginia Commonwealth University. For more information about Dr. Rosato’s research, please visit Dr. Adriana Rosato www.houstonmethodist.org/Rosato Houston Methodist Hospital Graduate Medical Education Office Recognizes Department Members for their Service The Houston Methodist Hospital Graduate Medical Education (GME) Office recently acknowledged several faculty members and residents from the Department of Pathology and Genomic Medicine for their service. Drs. Dina Mody, Suzanne Powell, and Arthur Zieske were recognized for their outstanding service and commitment to teaching cytopathology, neuropathology, and clinical pathology, respectively. Additionally, Jaclyn Jerz, M.D., a fourth-year resident in the Department, was recognized for her continued participation in GME activities. Congratulations!


The-Laboratory-Report_Fall-2014
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