Houston Methodist. Leading Medicine.
Houston Methodist. Leading Medicine

Department of Neurology

Stanley H. Appel

Stanley H. Appel, M.D.

Director, Methodist Neurological Institute
Peggy and Gary Edwards Distinguished Endowed Chair in ALS Research

Chair, Department of Neurology

Professor of Neurology
Weill Cornell Medical College

6560 Fannin Street, Suite 802
Houston, TX 77030

Phone: 713-441-3760

Stanley H. Appel, M.D. is the Director of the Methodist Neurological Institute, Peggy and Gary Edwards Distinguished Endowed Chair in ALS Research and Chair, Department of Neurology. He is also Professor of Neurology at Weill Cornell Medical College. Dr. Appel was previously Chair of the Department of Neurology at Baylor College of Medicine as well as Chief of the Neurology division and the James B. Duke Professor of Medicine at Duke University Medical Center, North Carolina.

Dr. Appel is a native of Massachusetts and received his Bachelor Degree at Harvard University and his Medical Degree from Columbia College of Physicians and Surgeons. He is Director of the MDA/ALS Research and Clinical Center at the Methodist Neurological Institute, and past Director of a National Institute of Aging Alzheimer's Disease Research Center.

Clinical Expertise:

  • Amyotrophic Lateral Sclerosis
  • Alzheimer’s disease
  • Neuromuscular diseases
  • Parkinson’s disease
  • Multisystem atrophy

Research Interests:

Mechanisms of neuronal injury and death in ALS, Parkinson's disease, and Alzheimer's disease. Cell lines as well as animal models are being used to define the pathways of cell injury and triggering factors such as autoimmunity. Increased intracellular calcium is one of the key constituents being studied.


  • M.D.  Columbia College of Physicians & Surgeons,  New York, NY
  • Resident in Neurology, Mount Sinai Hospital, New York, NY
  • Research Associate, Laboratory of Molecular Biology, National Institutes of Health, Bethesda, MD
  • Visiting Scientist, Visiting Scientist in Genetics and Neurology, Jackson Laboratory, Bar Harbor, ME
  • Associate in Medicine (Neurology), Duke University Medical Center, Durham, NC
  • Chief Resident in Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA

Selected Publications: