Houston Methodist. Leading Medicine.
Houston Methodist. Leading Medicine

Department of Neurology

Utilizing the latest and most advanced histology techniques, our laboratory processes and evaluates skeletal muscle and peripheral nerve to aid in diagnosing conditions such as inflammatory myopathies, muscular dystrophies, vasculitis, amyloidosis, sarcoidosis and inflammatory neuropathies. Light microscopy (paraffin and frozen sections), enzyme histochemistry, immunohistochemistry and ultrastructural (electron microscopy) studies are performed on muscle tissue. Nerve samples are evaluated by light microscopy, nerve teasing, resin-embedded light microscopy (semi-thin sections) and electron microscopy.

We provide surgical services for obtaining biopsies and also receive specimens from outside institutions. Our biopsies are all open biopsies performed under local anesthesia. Both the muscle and nerve biopsy incision sites are 3.5 – 5.5 cm in length, and five small samples of muscle (1 cm x 0.5 cm) with fascia are routinely collected. One nerve specimen 3 cm in length is collected and sent for processing. Instructions on how to handle and where to ship samples can be obtained by calling 713-441-3335. The final results of each study are integrated with clinical information to provide a diagnostic report to the clinician. A preliminary report is available in 48 hours, and a finalized report is available in one week. Photographs are included with each report. Additionally, a CD containing the report may be requested. Our staff is readily available to provide consultations for directing specialized studies or to discuss the neuromuscular case by telephone 713-441-3335.

Contact Information:

Muscle and Nerve Histopathology Laboratory
6560 Fannin, Suite 802
Houston, TX 77030

Phone: 713-441-3335
Fax: 713-790-3718