Houston Methodist. Leading Medicine.
Houston Methodist. Leading Medicine

Nazish Sayed, MBBS Ph.D.

Nazish Sayed, MBBS, Ph.D.

Assistant Member 
Department of Cardiovascular Sciences
Houston Methodist Research Institute

Assistant Professor of Cell Biology
Department of Cardiothoracic Surgery
Weill Cornell Medical College of Cornell University

E-mail:  nsayed@houstonmethodist.org
Phone: 713-441-4388


MBBS   University of Bombay, Bombay, India (Medicine)
Ph.D.   University of Medicine & Dentistry of New Jersey, Newark, NJ (Pharmacology & Physiology)

Postdoctoral Training

Intern, K. J. Somaiya Medical College, University of Mumbai, Mumbai, India
Resident, Medicine, Mahatma Gandhi Memorial Hospital, Mumbai, India
Postdoctoral Research Scientist, Physiology & Cell Biophysics, Columbia University, New York, NY
Postdoctoral Research Fellow, Cardiovascular Medicine, Stanford University, Stanford, CA



Dr. Nazish Sayed earned his MBBS degree from the University of Bombay, India. He trained in Internal Medicine and then obtained a Ph.D. degree in Physiology and Pharmacology at UMDNJ - New Jersey Medical School. He completed his postdoctoral training at Columbia University where he worked to develop novel therapeutic approaches for asthma and understand the basic mechanism for mediating airway smooth muscle contractility. He continued his postdoctoral training at Stanford University to gain additional experience in cardiovascular and regenerative medicine, focusing on developing reagents and protocols for a nonintegrative strategy of generating human induced pluripotent stem cells (iPSCs).

Dr. Sayed is an assistant member of the Houston Methodist Research Institute. His focus has been to understand the role of innate immunity in reprogramming and regeneration. Dr. Sayed is a member of American Heart Association (AHA) study sections and of several national and international societies, including the AHA and the International Society of Stem Cell Research.  

Description of Research

Dr. Sayed’s research focuses on understanding the role of innate immunity in reprogramming and regeneration. The goal of his research is to transfer basic bench research into clinical applications, using a vertically integrated approach with an amalgam of molecular, cellular, and biochemical tools. The aims of his research are to incorporate the newly acquired knowledge that innate immunity is required for nuclear reprogramming into the fields of transdifferentiation and vascular regeneration. His research is a logical extension of his previous work and interests in translational research in vascular biology.

Major Areas of Research

vascular biology, stem cells, transdifferentiation, innate immunity, cancer

Recent Publications

Fioramonti X, Deak A, Deshpande S, Carneiro L, Zhou C, Sayed N et al. Hypothalamic S-nitrosylation contributes to the counter-regulatory response impairment following recurrent hypoglycemia. PLoS One. 2013 Jul 19;8(7):e68709. PMID: 23894333

Lee J, Sayed N, Hunter A, Au KF, Wong WH, Mocarski ES, Pera RR, Yakubov E, Cooke JP. Activation of innate immunity is required for efficient nuclear reprogramming. Cell. 2012 Oct 26;151(3):547-58. PMID: 23101625

Wong WT, Huang NF, Botham CM, Sayed N, Cooke JP. Endothelial cells derived from nuclear reprogramming. Circ Res. 2012 Oct 26;111(10):1363-75. PMID: 23104878

Xiaoyu T, Wong W, Sayed N et al. NaHS relaxes rat cerebral artery in vitro via inhibition of L-type voltage-sensitive Ca2+ channel. Pharmacol Res. 2012 Feb;65(2):239-46. PMID: 22133671

Zhou Z, Sayed N, Pyriochou A, Roussos C, Fulton D, Beuve A, Papapetropoulos A.  Protein kinase G phosphorylates soluble guanylyl cyclase on serine 64 and inhibits its activity. Arterioscler Thromb Vasc Biol. 2008 Oct;28(10):1803-10. PMID: 18635821

Sayed N, David K, Fioramonti X, Toru I, Duran W, Beuve A.  Nitroglycerin-induced S-nitrosylation and desensitization of soluble guanylyl cyclase contributes to nitrate tolerance. Circ Res. 2008 Sep 12;103(6):606-14. PMID: 18669924

Ma X, Sayed N, Baskaran P, Beuve A, Van den Akker F. PAS-mediated dimerization of soluble guanylyl cyclase revealed by signal transduction histidine kinase domain crystal structure.  J Biol Chem. 2008 Jan 11;283(2):1167-78. PMID: 18006497

Sayed N, Baskaran P, Ma X, Van den Akker F, Beuve A. Desensitization of soluble guanylyl cyclase, the NO receptor, by S-nitrosylation. Proc Natl Acad Sci USA. 2007 Jul 24;104(30):12312-7. PMID: 17636120

Ma X, Sayed N, Beuve A, Van den Akker F.  NO and CO differentially activate soluble guanylyl cyclase via a heme pivot-bend mechanism. EMBO J. 2007 Jan 24;26(2):578-88. PMID: 17215864