Houston Methodist. Leading Medicine.
Houston Methodist. Leading Medicine

Methodist J.C. Walter Jr. Transplant Center - Houston, TX

Dr. R. Mark Ghobrial

R. Mark Ghobrial, M.D., Ph.D., FACS, FRCS (Ed)
Director of the Methodist Center for Liver Disease and Transplantation, Director of Liver Transplantation and Director of the Immunobiology Research Center.

R. Mark Ghobrial, M.D., Ph.D., FACS, FRCS (Ed)

Director, Methodist Center for Liver Disease & Transplantation
Chief, Liver Transplantation Surgery
Director, Immunobiology Research Center

Clinical Expertise

Selected Professional Activity

  • American Surgical Association
  • American Society of Transplantation
  • American Society of Transplant Surgeons
  • International Liver Transplantation Society
  • American Association of the Study of Liver Disease
  • Fellow, The Royal College of Surgeons, U.K.
  • American College of Surgeons and Surgical Biology Club II
  • Multiple National and International presentations and awards

Research Interest

  • Hepatitis C, transplant outcomes and partial liver grafting
  • Chronic Rejection, Immunosuppression and hepatobiliary cancer
  • Clinical Trials and National Institute of Health (NIH) sponsored research


  • Transplantation Fellowship – UCLA School of Medicine
  • Surgery Residency – University of Texas, Houston
  • Internship - Massachusetts General Hospital, Boston
  • Cairo University Medical School, Cairo, Egypt, 1980
  • PhD, Immunology – University of Texas, Houston
  • Research Fellowship in Transplantation – University of Texas
  • Research Fellowship in Immunology – Harvard University, Boston

Dr. R. Mark Ghobrial's Biography

R. Mark Ghobrial, M.D., Ph.D., FACS, FRCS (Ed) joined Houston Methodist Research Institute as Director of Immunobiology Biology Research Center in March 2008. He is also the Director of the Methodist Center for Liver Disease & Transplantation. Dr. Ghobrial came to Houston Methodist from the University of California, Los Angeles (UCLA), one of the largest liver transplant centers in the world. While at UCLA, he served as a Professor of Surgery and was a member of the Dumont-UCLA Liver Center.

His clinical and research interests include hepatobiliary disorders and liver disease; with a focus on Hepatitis C, hepatocellular carcinoma; transplant outcomes and immunosuppression. His basic science research focuses on chronic rejection and induction of transplantation tolerance.

Dr. Ghobrial obtained his M.D. degree at the Cairo University Medical School. He completed his Internship at Massachusetts General Hospital in Boston, Surgery Residency at University of Texas Health Science Center at Houston and a Multi-organ Transplantation Fellowship at University of California, Los Angeles (UCLA). Dr. Ghobrial also completed postdoctoral research training at Massachusetts General Hospital/Harvard Medical School and The University of Texas Health Science Center-Houston where he obtained a PhD at the Graduate School of Biomedical Sciences. After joining the faculty at UCLA, he quickly ascended the ranks to a full Professor of Surgery.

Dr. Ghobrial has been PI on several NIH grants and numerous clinical trials, published more than 100 articles in peer-reviewed journals and invited regularly to present at national and international meetings. He is a member of multiple national and international surgical and transplant societies. He is a Fellow in the Royal College of Surgeons-Edinburgh and a member of the American Surgical Association. Dr. Ghobrial serves on multiple committees in the American Society of Transplant Surgeons (ASTS), American Society of Transplantation (AST) and International Liver Transplantation Society (ILTS).