Michael Bruce Mann, Ph.D.
Senior Research Associate
Post-doctoral Research Associate, Mammalian Genetic Laboratory, Institute of Molecular & Cell Biology, Republic of Singapore
Cancer Research Training Award Fellow, Mouse Cancer Genetics Program, National Cancer Institute - Frederick, Frederick, MD, USA
Dr. Mann earned his Ph.D. in Genetics from the Case Western Reserve University School of Medicine in 2005. During postdoctoral training in the laboratory of Drs. Neal Copeland and Nancy Jenkins at the National Cancer Institute - Frederick in the USA and the Institute of Molecular and Cell Biology in Singapore, Dr. Mann trained in the design, implementation and analysis of forward genetic screens for cancer gene discovery in laboratory mice. His studies employed Sleeping Beauty transposon mutagenesis to generate several new mouse models of human skin, bone and blood cancers. The creation of these new mouse models of human cancer were instrumental in identifying new candidate cancer genes involved in the initiation, progression and maintenance of several solid tumors in laboratory mice. Dr. Mann joined The Methodist Hospital Research Institute as a Senior Research Associate in October of 2011.
Dr. Mann's research focuses on candidate cancer gene validation and translational genetic/genomic strategies for cancer therapy.
Cancer genetics/genomics, preclinical mouse models of cancer, transposon insertional mutagenesis, cancer gene discovery/validation, cancer systems genetics
Mann KM, Jenkins NA, Copeland NG, Mann MB. Transposon insertional mutagenesis models of cancer. Cold Spring Harb Protoc. 2014 Mar 1;2014(3). pii: pdb.top069849. PMID: 24591685.
Mann MB, Jenkins NA, Copeland NG, Mann KM. Sleeping Beauty mutagenesis: exploiting forward genetic screens for cancer gene discovery. Curr Opin Genet Dev. 2013 Dec 20;24C:16-22. PMID: 24657532.
Trevarton AJ, Mann MB, Knapp C, Araki H, Wren JD, Stones-Havas S, Black MA, Print CG. MelanomaDB: A Web Tool for Integrative Analysis of Melanoma Genomic Information to Identify Disease-Associated Molecular Pathways. Front Oncol. 2013 Jul 16;3:184. PMID: 23875173; PMCID: PMC3712543.
Goh AM, Lim CY, Chiam PC, Li L, Mann MB, Mann KM, Menendez S, Lane DP. Using targeted transgenic reporter mice to study promoter-specific p53 transcriptional activity. Proc Natl Acad Sci U S A. 2012;109(5):1685-90. PMID:22307631
Mann MB and Kaldis P. Cell cycle transitions and Cdk inhibition in melanoma therapy: Cyclin' through the options. Cell Cycle. 2011;10(9):1349. PMID:21464616
Mann MB, Hodges CA, Barnes E, Vogel H, Hassold TJ, and Luo G. Defective Sister-Chromatid Cohesion, Aneupolidy and Cancer Predisposition in a Mouse Model of Type II Rothmund-Thomson Syndrome. Hum. Mol. Genet. 2005 14: 813-825. PMID:15703196