Houston Methodist. Leading Medicine.
Houston Methodist. Leading Medicine

Michael Mann Ph.D.

Michael Bruce Mann, Ph.D.

Michael Bruce Mann, Ph.D.

 

Senior Research Associate
Cancer Research Program
Houston Methodist Research Institute

E-mail: mbmann@houstonmethodist.org
Phone: 713-441-1160


Education

B.S.   California State Polytechnic University, Pomona, CA (Biology)
M.S.   California State Polytechnic University, Pomona, CA (Biological Sciences)
Ph.D.   Case Western Reserve University, Cleveland, OH (Genetics)

Postdoctoral Training

Post-doctoral Research Associate, Mammalian Genetic Laboratory, Institute of Molecular & Cell Biology, Republic of Singapore

Cancer Research Training Award Fellow, Mouse Cancer Genetics Program, National Cancer Institute - Frederick, Frederick, MD, USA

 

Biography

Dr. Mann earned his Ph.D. in Genetics from the Case Western Reserve University School of Medicine in 2005.  During postdoctoral training in the laboratory of Drs. Neal Copeland and Nancy Jenkins at the National Cancer Institute - Frederick in the USA and the Institute of Molecular and Cell Biology in Singapore, Dr. Mann trained in the design, implementation and analysis of forward genetic screens for cancer gene discovery in laboratory mice. His studies employed Sleeping Beauty transposon mutagenesis to generate several new mouse models of human skin, bone and blood cancers.  The creation of these new mouse models of human cancer were instrumental in identifying new candidate cancer genes involved in the initiation, progression and maintenance of several solid tumors in laboratory mice.  Dr. Mann joined The Methodist Hospital Research Institute as a Senior Research Associate in October of 2011.

Description of Research

Dr. Mann's research focuses on candidate cancer gene validation and translational genetic/genomic strategies for cancer therapy.

Major Areas of Research

Cancer genetics/genomics, preclinical mouse models of cancer, transposon insertional mutagenesis, cancer gene discovery/validation, cancer systems genetics

Recent Publications  

Mann KM, Jenkins NA, Copeland NG, Mann MB. Transposon insertional mutagenesis models of cancer. Cold Spring Harb Protoc. 2014 Mar 1;2014(3). pii: pdb.top069849.  PMID: 24591685.

Mann MB, Jenkins NA, Copeland NG, Mann KM. Sleeping Beauty mutagenesis: exploiting forward genetic screens for cancer gene discovery. Curr Opin Genet Dev. 2013 Dec 20;24C:16-22. PMID: 24657532.

Trevarton AJ, Mann MB, Knapp C, Araki H, Wren JD, Stones-Havas S, Black MA, Print CG. MelanomaDB: A Web Tool for Integrative Analysis of Melanoma Genomic Information to Identify Disease-Associated Molecular Pathways. Front Oncol. 2013  Jul 16;3:184. PMID: 23875173;  PMCID: PMC3712543.

Goh AM, Lim CY, Chiam PC, Li L, Mann MB, Mann KM, Menendez S, Lane DP.  Using targeted transgenic reporter mice to study promoter-specific p53 transcriptional activity. Proc Natl Acad Sci U S A. 2012;109(5):1685-90. PMID:22307631

Mann MB and Kaldis P. Cell cycle transitions and Cdk inhibition in melanoma therapy: Cyclin' through the options. Cell Cycle. 2011;10(9):1349. PMID:21464616

Mann MB, Hodges CA, Barnes E, Vogel H, Hassold TJ, and Luo G.  Defective Sister-Chromatid Cohesion, Aneupolidy and Cancer Predisposition in a Mouse Model of Type II Rothmund-Thomson Syndrome. Hum. Mol. Genet. 2005 14: 813-825. PMID:15703196