Houston Methodist. Leading Medicine.
Houston Methodist. Leading Medicine

Methodist J.C. Walter Jr. Transplant Center - Houston, TX

Dr. Matthias Loebe

Principal Investigator

  1. H-19094 — INTERMACS – Interagency Registry of Mechanical Assisted Circulatory Support

  2. H-23461 — Levitronix CentriMag VAS Failure-to-Wean from Cardiopulmonary Bypass Pivotal Trial. Co-Investigator: Noon.

  3. H-24455 — Evaluation of the HeartWare® LVAD System for the Treatment of Advanced Heart Failure

  4. AN-4604 — Cardiac Assist Device Implantation Training

  5. H-11444 — International Society for Heart and Lung Transplantation (ISHLT) mechanical circulatory support database. Co-Investigator: Noon

  6. AN –2118 — Influence of hemodynamic alteration after brain death on the release of troponins, procalcitonins, and inflammatory mediators and the development of myocardial damage. Co-investigators: Noon, Youker, Thompson

  7. AN-3341 — A Training Module for Device Implantation of a Biventricular Assist Device Co-Investigators: Noon, Thompson

  8. H-12028 — Surgical Treatment for Ischemic Heart (STICH) failure trial. Co-Investigator: Noon

  9. H-10104 — Home Discharge Clinical Study of the Thoratec TLC II Portable Drive in the VAD System. Co-Investigators: Noon

  10. H-14915 — Database Analysis of LVAD Recipients. Co-Investigators: Noon, Youker, Thompson

  11. H-15095 — Clinical Trial of Therapeutic Apheresis for Dilated Cardiomyopathy. Co-investigators: Noon, Nose

  12. H-16558 — Use of Levitronix CentriMag Short-term Ventricular Assist System (VAS) in Post-cardiotomy Cardiogenic Shock. Co-Investigator: Noon


  1. H –9611 — Intrepid – A nonrandomized, controlled, feasibility study to evaluate the safety and effectiveness, of the Novacor Left Ventricular Assist System (LVAS) as an alterative to medical therapy in non-transplant eligible patients who are dependent on intravenous inotropic therapy for hemodynamic stability. Co-Investigator: Loebe

  2. H-14663 — Randomized Clinical Trial of the Safety and Efficacy of the DeBakey VAD as Destination Therapy in Patients with End-Stage Heart Failure. Co-Investigator: Loebe

  3. H-13231 — Heartmate LAS Suppport in Patients with Cardiogenic Shock Complicating and Acute Myocardial Infarction trial. Principal Investigator: Guillermo Torre-Amione Co-Investigators: Loebe

  4. H-14903 — Impella Recover Left Ventricular Support System: A Clinical Feasibility Study: Principal Investigator: Guillermo Torre-Amione. Co-Investigators: Loebe

  5. AN-3495 — Animal Training of Impella Cardio Systems Left Ventricular Recover Support Systems. Principal Investigator: Guillermo Torre-Amione Co-Investigators: Loebe

  6. H-14806 — Outcomes of Patients with Right Ventricular Dysfunction Following Insertion of MicroMed DeBakey Ventricular Assist Device. Principal Investigator: Luis Ivan Velez-Pestana, M.D. Co-Investigators: Loebe

  7. H-8527 — Clinical investigation of the miniaturized MicroMed DeBakey VAD for bridge to transplanting patients with end-stage heart failure.

  8. H-10697 — Evaluation of nitric oxide for the treatment of pulmonary hypertension.

  9. H-17219 — An Investigation of Stent Related Airway Granulation Tissue. Principal Investigator: Lunn. Co-Investigators: Loebe

  10. H-21448 — Microdebrider Bronchoscopy. Principal Investigator: Lunn. Co-Investigators: Loebe

  11. H-17770 — New Approach for the Treatment of DCM with Cryofiltration. Principal Investigator: Nose. Co-Investigators: Loebe

George P. Noon, MD, Principal Investigator

  1. H-12792 — Clinical Investigation of the MicroMed DeBakey VAD with Comparison to a Performance Goal to Establish Safety and Effectiveness of the Device as a Left Ventricular Support in Patients Awaiting Cardiac Transplantation. Co-Investigator: Loebe

  2. H-18981 — Pulmonary Hypertension Breakthrough Initiative (Study of Lung Transplant Recipient Native Lungs). Principal Investigator: Noon. Co-Investigator: Loebe

  3. H-19653 — The Predictive Value of QTC – Prolongation and QTC – Dispersion for the Diagnosis of Acute Allograft Rejection Utilizing a Computer Based Algorithm. Principal Investigator: Noon Co-Investigator: Loebe

  4. H-19654 — Congestive Heart Failure. Principal Investigator: Noon. Co-Investigator: Loebe

  5. H-19662 — Molecular Mechanisms of Congestive Heart Failure. Principal Investigator: Noon Co-Investigator: Loebe

Guillermo Torre-Amione, MD, PhD, Principal Investigator (Dept of Medicine, Cardiology)

  1. TMHRI – Study of Myocardial Structure and Function in Patients with End Stage Heart Failure in Need of Mechanical Support. Co-Investigators: Loebe.

  2. TMHRI – Heart Liver Immune Tolerance. Co-Investigators: Loebe.

  3. TMHRI – Evaluation of the VentrAssist™ Left Ventricular Assist Device for the Treatment of Advanced Heart Failure Destination Therapy. Co-Investigators: Loebe.

  4. TMHRI – Evaluation of the VentrAssist™ Left Ventricular Assist Device as Bridge to Transplantation - Pivotal Trial. Co-Investigators: Loebe.

Harish Seethamraju, MD, Principal Investigator (Pulmonary)

  1. H-16905 — Expression of Inducible Nitric Oxide Synthase in Primary Bronchial Epithelial Cells of Subjects with Lung Disease. Co-Investigators: Loebe.

  2. H-19893 — A Double-Blind, Placebo Controlled, Multicenter, Dose-ranging Study of an Anti-T- Lymphocyte Immuneglobulin (EZ-2053) in the Prophylaxis of Acute Pulmonary Rejection in Adult Recipients of Primary Pulmonary Allografts. Co-Investigators: Loebe.

Faisal Masud, MD, Principal Investigator (Anesthesia)

  1. TMHRI – Recombinant Factor VIIa Treatment for severe bleeding in post heart transplant and ventricular assist device implantation surgery patients: a retrospective analysis of safety and outcomes over a three year period. Co-Investigators: Loebe.

Neil Kleiman, MD Principal Investigator (Cardiology)

  1. TMHRI – A Prospective, multicenter, randomized (1:1) controlled trial of the IMPELLA® RECOVER® LP 2.5 System versus Intra Aortic Balloon Pump (IABP). Co-Investigators: Loebe.

  2. TMHRI – A Prospective, Multi-center, Randomized Controlled Trial of the IMPELLA RECOVER LP 2.5 System Versus Intra Aortic Balloon Pump (IABP) in Patients Undergoing Non-Emergent High Risk PCI. Co-Investigators: Loebe.

Brian Bruckner, MD, Principal Investigator, Cardiovascular Surgery

  1. TMHRI – Intramyocardial Delivery of Autologous Bone Marrow Cells in Patients with Heart Failure Due to Dilated Cardiomyopathy. Co-Investigators: Loebe.

Dipan Shah, Principal Investigator

  1. TMHRI – Histologic Correlates of Delayed Enhancement Cardiac Magnetic Resonance (CMR) in ischemic and Nonischemic Cardiomyopathies. Co-Investigators: Loebe.