Houston Methodist. Leading Medicine.
Houston Methodist. Leading Medicine

Department of Neurosurgery


Martyn A. Sharpe, Ph.D.

Research Scientist
Methodist Neurological Institute
Department of Neurosurgery
Houston Methodist Hospital

Phone: 713-441-3546
Fax: 713-793-7022
E-mail: masharpe@houstonmethodist.org

Dr. Sharpe is a chemistry-based biochemist and pharmacologist interested in the role of reactive oxygen and nitrogen species in patho-physiology. He trained in classical biochemistry, with a focus on mitochondrial function after acquiring a strong background in both organic and inorganic chemistry. After post-doctoral training in the United Kingdom, he served as a visiting professor at Michigan State University in East Lansing before joining the Methodist Neurological Institute.

Research Interests

His special research interest is in mitochondrial reactive oxidative/nitrosative species (RO/NS) damage, which has led him into design and synthesis a range of small, superoxide dismutase, catalase and glutathione peroxidase mimetics. To be able to study changes in cells caused by RO/NS, he has developed a number of quantitative assay systems to measure different types of DNA damage. Recently, he and other researchers at Houston Methodist have developed new technologies and drugs to treat glioma. The team recently licensed the rights to our first drug family to a venture capital company.

Education & Training

B.S., 1985, biochemistry, Chelsea College, London, UK
M.S., 1989, biochemistry, University of St. Andrews, Scotland, UK
Ph.D., 1993, biochemistry, Kings College London, London, UK

Postdoctoral Training
Post-doc researcher, 1993-19955 Brock University, St. Catherines, Ontario, Canada
Post-doc researcher, 1995-1999, University of Essex, UK
Fellow, 1999-2004, University College London Institute of Neurology, London, UK

Recent Publications

Sharpe, M.A., Marcano, D.C., Berlin, J. M., Widmayer, M.A., Baskin, D.S and Tour, J.M. (2012)
“Antibody-Targeted Nanovectors for the Treatment of Brain Cancers”
ACAS Nano. 6 (4) 3114-3120

Sharpe, M.A. Livingston, A.D. and Baskin, D.S. (2012)
“Thimerosal-Derived Ethylmercury Is a Mitochondrial Toxin in Human Astrocytes: Possible Role of Fenton Chemistry in the Oxidation and Breakage of mtDNA”
J. Toxicol. 373678

Sharpe, M.A., Widmayer, M.A and Baskin, D.S. (2010)
“Quantification and calibration of images in fluorescence microscopy”
Analytical Biochemistry. 404 (2), 118-126

Baskin, D.S., Widmayer, M.A and Sharpe, M.A. (2010)
“Quantification of DNase type I ends, DNase type II ends, and modified bases using fluorescently labeled ddUTP, terminal deoxynudeotidyl transferase, and formamidopyrimidine-DNA glycosylase”
BioTechniques 49 (1), 505-512

Sharpe, M. A and Ferguson-Miller, S (2008)
“A chemically explicit model for the mechanism of proton pumping in heme-copper oxidases”
Journal of Bioenergetics and Biomembranes 40, 541-549.