Luan Truong, M.D.
Luan Truong, M.D.
- Senior Member Houston Methodist Research Institute
- Medical Director, Nephropathology
- Department of Pathology and Genomic Medicine
- The Methodist Hospital Physician Organization
- Professor of Pathology and Laboratory Medicine
- Weill Cornell Medical College of Cornell University
- M.D. Pennsylvania State University, College of Medicine
- Pathology Residency, Baylor College of Medicine, Houston, TX
- Renal Pathology Fellowship, Columbia University, College of Physicians and Surgeons, New York, NY
Dr. Truong´s research interests involve surgical pathology and nephropathology. In the area of surgical pathology, he is interested in using morphology to define new diseases and to improve the diagnostic accuracy of known diseases. He combines traditional clinicopathologic observation with novel immunohistochemical techniques to study case materials drawn from more than 30,000 surgical pathology specimens submitted to the Department of Pathology annually. In the area of clinical nephropathology, Dr. Truong is interested in assessing the pathogenesis and natural behavior of several specific renal diseases using clinico-pathologic aproach, and has access to more than 10,000 renal biopsies accumulated in the renal pathology laboratory suitable for this purpose. In the area of experimental nephropathology, Dr. Truong’s research focuses on the pathogenesis of primary chronic tubulointerstitial nephritis. He has established a model of chronic obstructive uropathy by unilateral ligation of the ureter and has focused on cell cycle abnormality, including apoptosis and cell proliferation of tubular cells and interstitial cells as a crucial element in chronic tubulointerstitial injury. He is currently investigating preconditioning as a mechanism to attenuate acute tubular cell injury. He recently made the novel observation that activation of cell survival mechanisms, including the PI3 kinase pathway and survivin, may serve as important protective mechanisms. He also collaborates extensively with other investigators in Texas Medical Center and elsewhere in terms of morphologic support and structure-function correlation for studies on various renal diseases.
Major Areas of Research
- Kidney diseases; acute tubular cell injury; chronic tubulointerstitial injury; renal transplantation; renal neoplasms
- Ozcan A, Zhai Q, Javed R, Shen SS, Coffey D, Krishnan B, Truong LD. PAX-2 Is a Helpful Marker for Diagnosing Metastatic Renal Cell Carcinoma: Comparison With the Renal Cell Carcinoma Marker Antigen and Kidney-Specific Cadherin. Arch Pathol Lab Med. 2010 Aug;134(8):1121-9.
- Cheng J, Truong LD, Wu X, Kuhl D, Lang F, Du J. Serum- and glucocorticoid-regulated kinase 1 is upregulated following unilateral ureteral obstruction causing epithelial-mesenchymal transition. Kidney Int. 2010 Jul 14.
- Abdellatif AA, Waris S, Lakhani A, Kadikoy H, Haque W, Truong LD. True vasculitis in lupus nephritis. Clin Nephrol. 2010 Aug;74(2):106-12.
- Elbjeirami WM, Truong LD, Tawil A, Wang W, Dawson S, Lan HY, Zhang P, Garcia GE, Wayne Smith C. Early differential expression of oncostatin M in obstructive nephropathy. J Interferon Cytokine Res. 2010 Jul;30(7):513-23.
- Harvey AM, Grice B, Hamilton C, Truong LD, Ro JY, Ayala AG, Zhai QJ. Diagnostic utility of P504S/p63 cocktail, prostate-specific antigen, and prostatic acid phosphatase in verifying prostatic carcinoma involvement in seminal vesicles: a study of 57 cases of radical prostatectomy specimens of pathologic stage pT3b. Arch Pathol Lab Med. 2010 Jul;134(7):983-8.
- Yang G, Park S, Cao G, Goltsov A, Ren C, Truong LD, Demayo F, Thompson TC. MMTV promoter-regulated caveolin-1 overexpression yields defective parenchymal epithelia in multiple exocrine organs of transgenic mice. Exp Mol Pathol. 2010 Aug;89(1):9-19.
- Zhai QJ, Ozcan A, Hamilton C, Shen SS, Coffey D, Krishnan B, Truong LD. PAX-2 expression in non-neoplastic, primary neoplastic, and metastatic neoplastic tissue: A comprehensive immunohistochemical study. Appl Immunohistochem Mol Morphol. 2010 Jul;18(4):323-32.
- Dancer JY, Truong LD, Zhai Q, Shen SS. Expression of Galectin-3 in renal neoplasms: a diagnostic, possible prognostic marker. Arch Pathol Lab Med. 2010 Jan;134(1):90-4.
- Ge Y, Luna MA, Cowan DF, Truong LD, Ayala AG. Thyrolipoma and thyrolipomatosis: 5 case reports and historical review of the literature. Ann Diagn Pathol. 2009 Dec;13(6):384-9. Review.
- Newaz M, Ranganna K, Truong LD, Oyekan A. Effect of peroxisome proliferator-activated receptor-alpha siRNA on hypertension and renal injury in the rat following nitric oxide withdrawal and high salt diet. J Hypertens. 2009 Oct 14.
Dr. Truong's Biography
After completing his training in renal pathology in 1984, Dr. Truong joined the Department of Pathology, Baylor College of Medicine. He was promoted to Associate Professor in 1990, and Professor in 1996. He currently holds full-time faculty appointment in the Department of Pathology, Weill Medical College of Cornell University and in the Houston Methodist Research Institute. He also hold adjunct faculty appointment in the Departments of Pathology and Medicine, Baylor College of Medicine. He has been the attending pathologist for the Harris County Hospital District and Houston Methodist Hospital since 1984, and has served as Chief of Nephropathology since 1989. Dr. Truong also serves as the Director of the Pathology Core for the interdepartmental NIH-funded O’Brien Research Center on Renal Inflammation. Well recognized in the area of nephropathology, Dr. Truong actively participates in scholarly activities in this field as section editor and peer-reviewer for scientific journals, leader in professional societies, and lecturer in national and international scientific meetings.