Haifa Shen M.D., Ph.D.
|M.D.||Zhejiang University Medical School, Hangzhou, China|
|Ph.D.||The University of Texas at Houston, Graduate School of Biomedical Sciences|
Postdoctoral Fellow, National Cancer Institute, Frederick, MD
Dr. Shen earned his M.D. from Zhejiang University Medical School of Hangzhou, China in 1985, and his Ph. D. from the University of Texas at Houston in 1997. After completing a four-year postdoctoral fellowship at the National Cancer Institute, he worked on drug development at Lexicon Pharmaceuticals. He returned to the University of Texas at Houston Medical School as an assistant professor before becoming a member of The Methodist Hospital Research Institute in 2010.
Dr. Shen’s research interest is in the development of cancer therapeutics. His research approach combines drug chemistry and formulation, nanotechnology, and cancer biology. His research team has developed porous silicon microparticle-based drug carriers to specifically deliver chemotherapy drugs and gene-silencing agents such as siRNA and microRNA to tumor tissues for effective treatment of breast cancer, ovarian cancer, and pancreatic cancer. They have also successfully developed immune therapy for cancer prevention and treatment.
Drug delivery, experimental cancer therapy, cancer vaccine, and nanotechnology
Shen H, You J, Zhang G, Ziemys A, Li Q, Bai L, Deng X, Erm DR, Liu X, Li C, and Ferrari M. Cooperative, nanoparticle-enabled thermal therapy of breast cancer. Adv Healthc Mater. 2012 Jan 11;1(1):84-9. doi: 10.1002/adhm.201100005. PMID: 23184690
Fan J, Deng X, Gallagher JW, Huang Y, Wen J, Ferrari M, Shen H, and Hu Y. Monitoring the progression of metastatic breast cancer on nanoporous silica chips. Philos Trans A Math Phys Eng Sci. 2012 May 28;370(1967):2433-47. doi: 10.1098/rsta.2011.0444. PMID: 22509065
Shen H, Sun T, Ferrari M. Nanovector delivery of siRNA for cancer therapy. Cancer Gene Ther. 2012 Jun;19(6):367-73. doi: 10.1038/cgt.2012.22. PMID: 22555511
Yang Y, Wolfram J, Shen H, Fang X, and Ferrari M. Hesperetin: An inhibitor of the transforming growth factor (TGF-b) signaling pathway. Eur J Med Chem. 2012 Dec;58:390-5. doi: 10.1016/j.ejmech.2012.10.028. PMID: 23153811
Yang Y, Wolfram J, Boom K, Fang X, Shen H, and Ferrari M. Hesperetin impairs glucose uptake and inhibits proliferation of breast cancer cells. Cell Biochem Funct. 2013 Jul;31(5):374-9. doi: 10.1002/cbf.2905. PMID: 23042260
Shen H, Rodriguez-Aguayo C, Xu R, Liu X, Sood AK, Ferrari M, and Lopez-Berestein G. Enhancing chemotherapy response with sustained EphA2 silencing using multistage vector delivery. Clin Cancer Res. 2013 Apr 1;19(7):1806-15. doi: 10.1158/1078-0432.CCR-12-2764. PMID: 23386691
Shen H, Mittal V, Ferrari M, and Chang J. Delivery of gene silencing agents for breast cancer therapy. Breast Cancer Res. 2013 May 8;15(3):205. PMID: 23659575
Xu R, Huang Y, Guo X, Koay EJ, Liu X, Ferrari M, and Shen H. Multistage vectored siRNA targeting Ataxia-Telangiectasia Mutated for breast cancer therapy. Small. 2013 May 27;9(9-10):1799-808. doi: 10.1002/smll.201201510. PMID: 23293085
Fan J, Huang Y, Finoulst I, Wu H, Deng Z, Xu R, Xia X, Ferrari M, Shen H, and Hu Y. Serum peptidomic biomarkers for pulmonary metastatic melanoma identified by means of a nanopore-based assay. Cancer Lett. 2013 Jul 1;334(2):202-10. doi: 10.1016/j.canlet.2012.11.011. PMID: 23200677
Yang Y, Shen J, Yu X, Qin G, Zhang M, Shen H, Mao Z, and Ferrari M. Identification of an inhibitory mechanism of Luteolin on the insulin-like growth factor-1 ligand receptor interaction. Chembiochem. 2013 May 27;14(8):929-33. doi: 10.1002/cbic.201300082. PMID: 23630137
Deng X, Qing P, Luo M, Shao E, Zhao H, Yang X, Wang Y, Shen H, Jiao Z, and Wu M. Mesoporous silica coating on carbon nanotubes: layer-by-lauer method. Langmuir. 2013 Jun 11;29(23):6815-22. doi: 10.1021/la400690p. PMID: 23672683
Guo X, Yang C, Qian X, Lai T, Shen H, Fu L, and Xu B. Estrogen receptor alpha regulates ATM expression through miRNAs in breast cancer. Clin Cancer Res. 2013 Sep 15;19(18):4994-5002. doi: 10.1158/1078-0432.CCR-12-3700. PMID: 23857602
Li Y, Li Y, Chen T, Kuklina A, Bernard P, Esteva FJ, Shen H, Ferrari M, Hu Y. Circulating proteolytic products of carboxypeptidase N for early detection of breast cancer. Clin Chem. 2013 Oct 21. [Epub ahead of print]. PMID: 24146311
Shen J, Xu R, Mai J, Kim H, Guo X, Qin G, Yang Y. Wolfram J, Mu C, Xia X, Gu J, Liu, X, Mao Z, Ferrari M, and Shen H. High capacity nanoporous silicon carrier for systemic delivery of gene silencing therapeutics. ACS Nano. 2013 Oct 18. [Epub ahead of print]. PMID: 24131405
Zhang M, Xu R, Xia X, Yang Y, Gu J, Qin G, Liu X, Ferrari M, and Shen H. Polycation-functionalized nanoporous silicon particles for gene silencing on breast cancer cells. Biomaterials. 2014 Jan;35(1):423-31. doi: 10.1016/j.biomaterials.2013.09.033. PMID: 24103653