Guangjun Nie, Ph.D.
Senior Affiliate Member
Professor of Nanobiology and Nanomedicine
Postdoctoral Fellow, Jewish General Hospital, McGill University (Blood Physiology)
Dr. Nie earned his Ph.D. in Biochemistry and Biophysics from the Institute of Biophysics, Chinese Academy of Sciences in 2002. He holds a faculty appointment at the National Centre for Nanoscience and Technology, China, and became a senior affiliate member of The Methodist Hospital Research Institute in 2011. Dr. Nie also holds an adjunct faculty appointment at East China University Science and Technology, China. As a senior affiliate member of the TMHRI Department of Nanomedicine, he directs a research program focusing on the use of multifunctional nanomaterials to regulate tumor cells and their microenvironments. He has a particular interest in the effects of nanomaterials on tumor associated macrophages and fibroblasts and how these relate to tumor growth and metastasis. By choosing nanostructures with specific functional properties, Dr. Nie's laboratory has designed a range of effective antitumor agents.
Dr. Nie's research program focuses on defining the biophysicochemical interactions of nanomaterials with various biological barriers (nano-bio interfaces), and the development of antitumor therapeutics based on nanotechnology-enabled techniques. His research explores the relationships between nanostructures and their biological effects, as well as links between biomimetic nanomaterials and cellular and physical barriers, especially in tumor tissue.
Cancer, nanotechnology, blood, biomimetic, nanosafety
Liu G, Niu S, Dong A, Cai H, Anderson GJ, Han B, Nie G. A Chinese family carrying novel mutations in SEC23B and HFE2, the genes responsible for congenital dyserythropoietic anaemia II (CDA II) and primary iron overload, respectively. Br J Haematol. 2012 Mar 20. PMID: 22428539
Wan L, Nie G, Zhang J, Zhao B. Overexpression of Human Wild-Type Amyloid -β protein precursor decreases the iron content and increases the oxidative stress of neuroblastoma SH-SY5Y cells. J of Alzheimers Dis. 2012 Mar 26. PMID: 22451308
Zhu M, Li Y, Shi J, Feng W, Nie G, and Zhao Y. Exosomes as extrapulmonary signaling conveyors for nanoparticle-induced systemic immune activation. Small. 2012;8(3):404-412. PMID: 22144073
Zhou X, Lan J, Liu G, Deng K, Yang Y, Nie G, Yu J, Zhi L. Facet-mediated photodegradation of organic dye over hematite architectures by visible light. Angew Chem Int Ed Engl. 2012;51(1):178-182. PMID: 22086657
Fan Z, Yang X, Li Y, Li S, Niu S, Wu X, Wei J, Nie G. Deciphering an underlying mechanism of differential cellular effects of nanoparticles: an example of Bach-1 dependent induction of HO-1 expression by gold nanorod. Biointerphases. 2012;7(10):1-8.
Chen H, Zhao Y, Wang H, Nie G, Nan K. Co-delivery strategies based on multifunctional nanocarriers for cancer therapy. Curr Drug Metab. 2012 Feb 29. PMID: 22380013
Lan J, Zhou X, Liu G, Yu J, Zhang J, Zhi L, Nie G. Enhancing photocatalytic activity of one-dimensional KNbO3 nanowires by Au nanoparticles under Ultraviolet and Visible-light. Nanoscale. 2011;3:5161-7. DOI: 10.1039/C1NR10953G
Ning B, Liu G, Liu Y, Su X, Anderson GJ, Zheng X, Chang Y, Guo M, Liu Y, Zhao Y, Nie G. 5-aza-2'-deoxycytidine activates iron uptake and heme biosynthesis by increasing c-Myc nuclear localization and binding to the E-boxes of TfR1 and ferrochelatase (Fech) genes. J Biol Chem. 2011;286(43):37196-206. PMID: 21903580
Wang H, Zhao Y, Wu Y, Nan K, Nie G, Chen H. Enhanced anti-tumor efficacy by co-delivery of doxorubicin and paclitaxel with amphiphilic methoxy PEG-PLGA copolymer nanoparticles. Biomaterials. 2011; 32(32) 8281-90. PMID: 21807411
Li Y, Zhou Y, Wang HY, Perrett S, Zhao Y, Tang Z, Nie G. Chirality of Glutathione Surface Coating Affects the Cytotoxicity of Quantum Dots. Angew Chem Int Ed Engl. 2011;50(26):5860-4. PMID: 21567671
Sun C, Yang H, Yuan Y, Tian X, Wang L, Guo Y, Xu L, Lei J, Gao N, Anderson GJ, Liang XJ, Chen C, Zhao Y, Nie G. Controlling assembly of paired gold clusters within apoferritin nanoreactor for in vivo kidney targeting and biomedical imaging. J Am Chem Soc. 2011;133(22):8617–24. PMID: 21542609
Zhang Z, Zhang F, An P, Guo X, Shen Y, Tao Y, Wu Q, Zhang Y, Yu Y, Ning B, Nie G, Knutson MD, Anderson GJ, Wang F. Ferroportin1 deficiency in mouse macrophages impairs iron homeostasis and inflammatory responses. Blood. 2011;118(7):1912-22. PMID: 21705499
Liu G, Li X, Shu H, Hu YL, Anderson G, Qian J, Nie G. Identification of two novel PBGD mutations in acute intermittent porphyria patients accompanying anemia in mainland China. Blood Cells Mol Dis. 2011;47 (2):138-9. PMID: 21669542
Zhang W, Sun B, Zhang L, Zhao B, Nie G, Zhao Y. Biosafety assessment of Gd@C82(OH)22 nanoparticles on Caenorhabditis elegans. Nanoscale. 2011; 3(6):2636–41. PMID: 21541378
Fan J, Yin JJ, Ning B, Wu X, Hu Y, Ferrari M, Anderson GJ, Wei J, Zhao Y, Nie G. Direct evidence for catalase and peroxidase activities of ferritin-platinum nanoparticles. Biomaterials. 2011;32(6):1611-8. PMID: 21112084
Wan L, Nie G, Zhang J, Luo Y, Zhang P, Zhang Z, Zhao B. β-amyloid peptide increases levels of iron content and oxidative stress in human cell and Caenorhabditis elegans models of Alzheimer disease. Free Radic Biol Med. 2011;50(1):122-9. PMID: 21034809
Miao Q, Xu D, Wang Z, Xu L, Wang T, Wu Y, Lovejoy DB, Kalinowski DS, Richardson DR, Nie G, Zhao Y. Amphiphilic hyper-branched co-polymer nanoparticles for the controlled delivery of anti-tumor agents. Biomaterials. 2010;31(28):7364-75. PMID: 20599267
Wang Y, Juan LV, Ma X, Wang D, Ma H, Chang Y, Nie G, Jia L, Duan X, Liang XJ. Specific hemosiderin deposition in spleen induced by a low dose of cisplatin: altered iron metabolism and its implication as an acute hemosiderin formation model. Curr Drug Metab. 2010;11(6):507-15. PMID: 20540689
Zhang Y, Mikhael M, Xu D, Li Y, Soe-Lin S, Ning B, Li W, Nie G, Zhao Y, Ponka P. Lysosomal proteolysis is the primary degradation pathway for cytosolic ferritin and cytosolic ferritin degradation is necessary for iron exit. Antioxid Redox Signal. 2010;13(7): 999-1009. PMID: 20406137
Soe-Lin S, Apte SS, Mikhael, MR , Kayembe LK, Nie G, Ponka, P. Both Nramp1 and DMT1 are necessary for efficient macrophage iron recycling. Exp Hematol. 2010;38(8):609–17. PMID: 20394798
Shi ZH, Nie G, Duan XL, Rouault T, Wu WS, Ning B, Zhang N, Chang YZ, Zhao BL. Neuroprotective mechanism of mitochondrial ferritin on 6-hydroxydopamine-induced dopaminergic cell damage: implication for neuroprotection in Parkinson’s disease. Antioxid & Redox Signal. 2010 Sep 15;13(6):783-96. PMID: 20121342
Xu J, Song J, Su J, Wei J, Yu Y, Lv S, Li W, Nie G. A new human catalytic antibody Se-scFv-2D8 and its selenium-containing single domains with high GPX activity. J of Mol Recognit. 2010;23(4): 352–9. PMID: 19938186