Houston Methodist. Leading Medicine.
Houston Methodist. Leading Medicine

Glenn Winnier, Ph.D.

Glenn Winnier, Ph.D. 

Glenn Winnier, Ph.D.

Glenn Winnier, Ph.D.

Assistant Member
Project Director
Genomic Medicine Program
The Methodist Hospital Research Institute

Email: gewinnier@houstonmethodist.org
Phone: 713-441-2049


Education

B.S.  

Emory University,  Atlanta, GA (Biology & Anthropology)

Ph.D.  

Vanderbilt University,  Nashville, TN (Cell Biology)

Postdoctoral Training

 Postdoctoral Fellow, Department of Medicine, Vanderbilt University

 Associate Fellow, Howard Hughes Medical Institute, Vanderbilt University

Biography

Dr. Winnier received his Ph.D. in Cell Biology from Vanderbilt University in 1997. He then completed a postdoctoral fellowship in the department of medicine at Vanderbilt University. In 2011, Dr. Winnier joined The Methodist Hospital Research Institute diabetes and metabolic disease research program. 

Prior to joining TMHRI, Dr. Winnier was director of stem cell research for Opexa Therapeutics.  At TMHRI, Dr. Winnier is responsible for scientific and administrative coordination of the joint TMHRI/University of Houston Texas International Center for Nuclear Receptors, an initiative funded by the State of Texas Emerging Technology Fund.  Dr. Winnier develops strategies to develop the commercial potential of the TICNR and acts as liaison between the TICNR and other academic and industry organizations for collaborative research projects.

Description of Research

Dr. Winnier’s research focuses on identifying and developing innovative products and technologies that can be used for the advancement of novel therapies for the treatment of human diseases.  This includes the development of human monocyte-derived stem cell technology, focusing on the differentiation of these stem cells into insulin-producing cells for the treatment of diabetes.  He has also generated targeted mutations to help identify genes whose human orthologs drive disease conditions. 

Major Areas of Research

Diabetes, stem cells

Recent Publications

Winnier GE, Kume T, Deng K, Rogers R, Bundy J, Raines C, Walter MA, Hogan BL, Conway SJ. Roles for the winged helix transcription factors MF1 and MFH1 in cardiovascular development revealed by nonallelic noncomplementation of null alleles. Dev Biol. 1999 Sep 15;213(2):418-31. PMID: 10479458

Weisberg E, Winnier GE, Chen X, Farnsworth CL, Hogan BL, Whitman M. A mouse homologue of FAST-1 transduces TGF beta superfamily signals and is expressed during early embryogenesis. Mech Dev. 1998 Dec;79(1-2):17-27. PMID: 10349617

Wu SC, Grindley J, Winnier GE, Hargett L, Hogan BL. Mouse Mesenchyme forkhead 2 (Mf2): expression, DNA binding and induction by sonic hedgehog during somitogenesis. Mech Dev. 1998 Jan;70(1-2):3-13. PMID: 9510020

Dunn NR, Winnier GE, Hargett LK, Schrick JJ, Fogo AB, Hogan BL. Haploinsufficient phenotypes in Bmp4 heterozygous null mice and modification by mutations in Gli3 and Alx4. Dev Biol. 1997 Aug 15;188(2):235-47. PMID: 9268572

Labosky PA, Winnier GE, Jetton TL, Hargett L, Ryan AK, Rosenfeld MG, Parlow AF, Hogan BL. The winged helix gene, Mf3, is required for normal development of the diencephalon and midbrain, postnatal growth and the milk-ejection reflex. Development. 1997 Apr;124(7):1263-74. PMID: 9118797

Winnier GE, Hargett L, Hogan BL. The winged helix transcription factor MFH1 is required for proliferation and patterning of paraxial mesoderm in the mouse embryo. Genes Dev. 1997 Apr 1;11(7):926-40. PMID: 9106663

Ji QS, Winnier GE, Niswender KD, Horstman D, Wisdom R, Magnuson MA, Carpenter G.  Essential role of the tyrosine kinase substrate phospholipase C-gamma1 in mammalian growth and development. Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):2999-3003. PMID: 9096335

Farmer SC, Sun CW, Winnier GE, Hogan BL, Townes TM. The bZIP transcription factor LCR-F1 is essential for mesoderm formation in mouse development. Genes Dev. 1997 Mar 15;11(6):786-98. PMID: 9087432