Zeenat Safdar, MD

Associate Professor of Medicine, Institute for Academic Medicine
Associate Clinical Member, Research Institute
Associate Director, Pulmonary Disease & Critical Care Fellowship, Department of Medicine
Houston Methodist
Weill Cornell Medical College


Biography

Dr. Zeenat Safdar is an Associate Professor of Medicine at the Institute of Academic Medicine, Director of Clinical Research and Pulmonary Hypertension Program at the Houston Methodist Hospital Lung Center in Houston, Texas. She is also an Adjunct Associate Professor of Medicine at Baylor College of Medicine.

Dr. Safdar serves as a Chair of Young Council at Pulmonary Vascular Research Institute, Pulmonology Chair at the Pulmonary Hypertension Association Online University, and National Chair at PHA on the Road program. She serves as Registries and Databases Workforce leader at PH council of International Society of Heart Lung Transplantation (ISHLT).

Dr. Safdar is a Fellow of the American College of Physicians, American College of Chest Physicians (CHEST), and Pulmonary Vascular Research Institute. She is a member of the PH Council of International Society of Heart Lung Transplant, American Thoracic Society and Texas Medical Association.

She has been invited to serve as the session facilitator, presenter, and abstract reviewer and selector at the International Conference of the ATS, CHEST and ISHLT. Dr. Safdar has served as an invited reviewer for the American Journal of Respiratory and Critical Care Medicine, Respiratory Medicine and Therapeutic Advances in Respiratory Disease and serves as a member of the editorial board of several journals.

Description of Research

Dr. Safdar’s principal area of interest is Pulmonary Arterial Hypertension (PAH), specifically translational research, clinical research and clinical trials. Her recent research has focused on the contribution of renin-angiotensin-aldosterone system to the pathophysiology of PAH. She is the principal and co-investigator of several ongoing clinical trials including

  • REATA - a phase 2 dose-ranging study of efficacy and safety of Bardoxolone Methyl in PAH
  • LIBERTY - a phase 2 study of Ubenimex in patient with PAH
  • TRANSIT-1 - a study to Assess the Tolerability and the Safety of the Transition From Inhaled Treprostinil to Oral Selexipag in PAH
  • Chronic ThromboEmbolic Pulmonary Hypertension registry
  • TRITON - The Efficacy and Safety of Initial Triple Versus Initial Dual Oral Combination Therapy in Patients With Newly Diagnosed PAH
  • RIN-PH - Safety and Efficacy of Inhaled Treprostinil in Adult PH With ILD Including CPFE

 The Houston Methodist Hospital Pulmonary Hypertension program also provides expert care for patients with idiopathic pulmonary fibrosis (IPF). As a Director of the IPF program, she serves as a lead investigator of several ongoing IPF clinical trials including 

  • RIFF study - a phase 2 randomized placebo-controlled clinical study to assess the safety and efficacy of Lebrikizumab in IPF
  • RAINIER study - a phase 2 multicenter study to assess the efficacy and safety of Simtuzamab in IPF

 She was the site investigator of several complete IPF clinical trials such as

  • ARTEMIS-IPF - ambrisentan for IPF
  • ARTEMIS-PH - ambrisentan in PH associated with IPF
  • MUSIC - macitentan for IPF

 Dr. Safdar is the recipient of a K23 grant from the National Institute of Health (NIH) and several other grants from non-profit organizations.  Her research has been published in prominent, high impact journals.

Areas Of Expertise

Pulmonary Arterial Hypertension (PAH) Idiopathic Pulmonary Fibrosis (IPF) Pulmonary disease
Publications

Longitudinal change in pulmonary arterial capacitance as an indicator of prognosis and response to therapy and in pulmonary arterial hypertension
Medrek, SK, Kloefkorn, C, Nguyen, DTM, Graviss, EA, Frost, AE & Safdar, Z 2017, Pulmonary circulation, vol 7, no. 1. DOI:

Tolerability of Switch to Macitentan from Bosentan in Pulmonary Arterial Hypertension
Safdar, Z, Thakur, A & Frost, A 2017, Southern Medical Journal, vol 110, no. 3, pp. 223-228. DOI:

Efficacy of 1, 5, and 20mg oral sildenafil in the treatment of adults with pulmonary arterial hypertension: A randomized, double-blind study with open-label extension
Vizza, CD, Sastry, BKS, Safdar, Z, Harnisch, L, Gao, X, Zhang, M, Lamba, M & Jing, ZC 2017, BMC Pulmonary Medicine, vol 17, no. 1, 44. DOI:

Longitudinal change in pulmonary arterial capacitance as an indicator of prognosis and response to therapy and in pulmonary arterial hypertension
Medrek, SK, Kloefkorn, C, Nguyen, DTM, Graviss, EA, Frost, AE & Safdar, Z 2017, Pulmonary Circulation, vol 7, no. 2, pp. 399-408. DOI:

Critical role for IL-18 in spontaneous lung inflammation caused by autophagy deficiency
Fattah, EA, Bhattacharya, A, Herron, A, Safdar, Z & Eissa, NT 2015, Journal of Immunology, vol 194, no. 11, pp. 5407-5416. DOI:

Pulmonary artery diastolic pressure gradient as an indicator of severity of illness in patients with pulmonary hypertension related to left-sided heart disease
Howard, C, Rangajhavala, K & Safdar, Z 2015, Therapeutic Advances in Respiratory Disease, vol 9, no. 2, pp. 35-41. DOI:

Correction to Circulating Collagen Biomarkers as Indicators of Disease Severity in Pulmonary Arterial Hypertension [J Am Coll Cardiol HF, (2014), 2, 412-421]
Safdar, Z, Tamez, E, Chan, W, Arya, B, Ge, Y, Deswal, A, Bozkurt, B, Frost, A & Entman, M 2015, JACC: Heart Failure, vol 3, no. 4, pp. 345. DOI:

Plasma 15-F2t-isoprostane in idiopathic pulmonary arterial hypertension
Zhang, R, Sun, ML, Fan, YF, Jiang, X, Zhao, QH, He, J, Wang, L, Shailendra, PK, Safdar, Z & Jing, ZC 2014, International Journal of Cardiology, vol 175, no. 2, pp. 268-273. DOI:

Long-term follow-up of portopulmonary hypertension patients after liver transplantation
Khaderi, S, Khan, R, Safdar, Z, Stribling, R, Vierling, JM, Goss, JA & Sussman, NL 2014, Liver Transplantation, vol 20, no. 6, pp. 724-727. DOI:

Circulating Collagen Biomarkers as Indicators of Disease Severity in Pulmonary Arterial Hypertension
Safdar, Z, Tamez, E, Chan, W, Arya, B, Ge, Y, Deswal, A, Bozkurt, B, Frost, A & Entman, M 2014, JACC: Heart Failure, vol 2, no. 4, pp. 412-421. DOI:

Macitentan for the treatment of idiopathic pulmonary fibrosis: The randomised controlled MUSIC trial
Raghu, G, Million-Rousseau, R, Morganti, A, Perchenet, L, Behr, J, Goh, N, Glanville, A, Musk, M, Hopkins, P, Lien, DC, Chan, C, Rolf, JD, Wilcox, P, Cox, PG, Manganas, H, Cottin, V, Valeyre, D, Walleart, B, Andreas, S, Neurohr, C, Guenther, A, Schönfeld, N, Koch, A, Kramer, M, Breuer, R, Ben-Dov, I, Fink, G, Schwarz, Y, Albera, C, Confalonieri, M, Saltini, C, Harari, S, Flezar, M, Greenblatt, M, Ras, GJ, Morell, F, Alvarez-Sala, JL, Xaubet, A, Sueiro, A, Linares, MJ, Sköld, M, Kayacan, O, Mogulkoc, N, Chan, A, Chapman, J, Parambil, J, Ettinger, N, Golden, J, Meyer, KC, Swigris, JJ, Yung, GL, Antin-Ozerkis, D, Mohabir, PK, Wesselius, LJ, De Andrade, J, Cordova, F, Safdar, Z & Wencel, M 2013, European Respiratory Journal, vol 42, no. 6, pp. 1622-1632. DOI:

Pulmonary hypertension complicated by pericardial effusion: A single center experience
Honeycutt, GR & Safdar, Z 2013, Therapeutic Advances in Respiratory Disease, vol 7, no. 3, pp. 151-159. DOI:

Treatment of idiopathic pulmonary fibrosis with Ambrisentan: A parallel, randomized trial
Raghu, G, Behr, J, Brown, KK, Egan, JJ, Kawut, SM, Flaherty, KR, Martinez, FJ, Nathan, SD, Wells, AU, Collard, HR, Costabel, U, Richeldi, L, De Andrade, J, Khalil, N, Morrison, LD, Lederer, DJ, Shao, L, Li, X, Pedersen, PS, Montgomery, AB, Chien, JW, O’Riordan, TG, Amin, D, Baker, A, Baratz, D, Baughman, R, Cagino, A, Chan, A, Chapman, J, Cordova, F, De Andrade, J, Edelman, J, Enelow, R, Ettinger, N, Glassberg, M, Golden, J, Ilowite, J, Kreider, M, Kureishy, S, Lancaster, L, Lederer, D, Limper, A, Morrison, L, Nathan, S, Strek, M, Padilla, M, Fisher, M, Riley, D, Mohabir, P, Safdar, Z, Sahn, S, Schaumberg, T, Beth Scholand, M, Smith, C, Sussman, R, Yung, G, Saggar, R, Zibrak, J, Alvarez, J, Chan, K, Ruzi, J, McConnell, J, Mehta, J, Verghese, G, Talwar, A, Haddad, T, Sood, N, Goldberg, H, Sundar, K, Ziedalski, T, Gibson, K, Chan, C, Lien, D, Fell, C, Fox, G, Khalil, N, Poirier, C, Provencher, S, Wilcox, P, Vilayi-Weiler, Z, Kramer, M, Yigla, M, Baloira, A, Behr, J, Parakova, Z, Schwarz, Y, Martinez, C, Ben-Dov, I, Kahler, C, Xaubet, A, Skrickova, J, Kolek, V, Parfrey, H, Echave-Sustaeta, J, Wuyts, W, Geiser, T, Muller-Quernheim, J, Whyte, M, Pfeifer, M, Grohe, C, Block, LH, Bourdin, A, Olschewski, H, Sibille, Y, Snizek, T, Vytiska, J, Pesek, M, Crestani, B, Wallaert, B, Chanez, P, Israel Biet, D, Dromer, C, Costabel, U, Gläser, S, Wagner, U, Witt, C, Herth, F, Hoeffken, G, Egan, J, Breuer, R, Adir, Y, Agostini, C, Cremona, G, Vitulo, P, Poletti, V, Rottoli, P, Rybacki, C, Piotrowski, W, Morera, J, Hattotuwa, K, Warburton, C, Corris, P, Leonard, C, Booth, H, Britton, M, Richeldi, L, Marchand-Adam, S, Marquette, CH, Tamm, M, Lazor, R, Chalmers, GW, Hirani, N, De Vuyst, P, Saltini, C, Alfonso Harari, S, Maher, T, Campos, F, Ramirez, A, Wehbe, L, Altieri, H, Matsuno Fuchigami, A, Cartagena Salinas, C, Mattos, W, Posadas, R, Fiss, E, Diaz-Castanon, J, Munoz, S, Natera Ramirez, L, Chercoff, J, Cezar Fritscher, C, Cardoso, A, Moreira, MAC, Steidle, L, Arakaki, J, Florenzano, M, Pun Leon, L, Bernardini, SUC, Gilberto, A, Duque, CAT, Awad, C, Severiche, D, Grimaldos, FB, Rubin, A, Barrera, CI, Salazar Ore, DJ, Mazzei, J, Matiz, C, Glanville, A, Hopkins, P, Smallwood, D, Veitch, E, Musk, M, Glaspole, I, Wood-Baker, R & Veale, A 2013, Annals of Internal Medicine, vol 158, no. 9, pp. 641-649.

Pulmonary Hypertension
Safdar, Z 2013, . in Cardiology Secrets: Fourth Edition. Elsevier, pp. 426-432. DOI:

Management of pulmonary arterial hypertension during pregnancy: A retrospective, multicenter experience
Duarte, AG, Thomas, S, Safdar, Z, Torres, F, Pacheco, LD, Feldman, J & DeBoisblanc, B 2013, Chest, vol 143, no. 5, pp. 1330-1336. DOI:

Pulmonary arterial hypertension in pregnant women
Safdar, Z 2013, Therapeutic Advances in Respiratory Disease, vol 7, no. 1, pp. 51-63. DOI:

Rapid Transition from Inhaled Iloprost to Inhaled Treprostinil in Patients with Pulmonary Arterial Hypertension
Bourge, RC, Tapson, VF, Safdar, Z, Benza, RL, Channick, RN, Rosenzweig, EB, Shapiro, S, White, RJ, Mcswain, CS, Gotzkowsky, SK, Nelsen, AC & Rubin, LJ 2013, Cardiovascular Therapeutics, vol 31, no. 1, pp. 38-44. DOI:

Pulmonary Hypertension; A Woman's Disease
Safdar, Z 2013, Texas Heart Institute Journal, vol 40, no. 3, pp. 302-303.

Clinical implications of haemoptysis in patients with pulmonary arterial hypertension.
Cantu, J, Wang, D & Safdar, Z 2012, International Journal of Clinical Practice, vol 66, no. SUPPL. 177, pp. 5-12. DOI:

Portopulmonary hypertension: An update
Safdar, Z, Bartolome, S & Sussman, N 2012, Liver Transplantation, vol 18, no. 8, pp. 881-891. DOI: