Yvonne Kew,

Houston Methodist
Weill Cornell Medical College


Areas Of Expertise

Metastatic brain tumors Primary brain tumors Immune response
Publications

Maintenance therapy with tumor-Treating fields plus temozolomide vs temozolomide alone for glioblastoma a randomized clinical trial
Stupp, R, Taillibert, S, Kanner, AA, Kesari, S, Steinberg, DM, Toms, SA, Taylor, LP, Lieberman, F, Silvani, A, Fink, KL, Barnett, GH, Zhu, JJ, Henson, JW, Engelhard, HH, Chen, TC, Tran, DD, Sroubek, J, Tran, ND, Hottinger, AF, Landolfi, J, Desai, R, Caroli, M, Kew, Y, Honnorat, J, Idbaih, A, Kirson, ED, Weinberg, U, Palti, Y, Hegi, ME & Ram, Z 2015, JAMA - Journal of the American Medical Association, vol 314, no. 23, pp. 2535-2543. DOI:

Erratum: Clinical Practice Experience With NovoTTF-100A™ System for Glioblastoma: The Patient Registry Dataset (PRiDe) (Seminars in Oncology (2014) 41:5 (S4-S13))
Mrugala, MM, Engelhard, HH, Dinh Tran, D, Kew, Y, Cavaliere, R, Villano, JL, Annenelie Bota, D, Rudnick, J, Love Sumrall, A, Zhu, JJ & Butowski, N 2015, Seminars in Oncology, vol 42, no. 3, pp. e33. DOI:

Clinical practice experience with NovoTTF-100A™ system for glioblastoma: The patient registry dataset (PRiDe)
Mrugala, MM, Engelhard, HH, Dinh Tran, D, Kew, Y, Cavaliere, R, Villano, JL, Annenelie Bota, D, Rudnick, J, Love Sumrall, A, Zhu, JJ & Butowski, N 2014, Seminars in Oncology, vol 41, no. S6, pp. S4-S13. DOI:

Overexpression and constitutive nuclear localization of cohesin protease Separase protein correlates with high incidence of relapse and reduced overall survival in glioblastoma multiforme
Mukherjee, M, Byrd, T, Brawley, VS, Bielamowicz, K, Li, XN, Merchant, F, Maitra, S, Sumazin, P, Fuller, G, Kew, Y, Sun, D, Powell, SZ, Ahmed, NM, Zhang, N & Pati, D 2014, Journal of Neuro-Oncology, vol 119, no. 1, pp. 27-35. DOI:

Erratum to: Overexpression and constitutive nuclear localization of cohesin protease Separase protein correlates with high incidence of relapse and reduced overall survival in glioblastoma multiforme (Journal of Neuro-Oncology DOI: 10.1007/s11060-014-1458-6)
Mukherjee, M, Byrd, T, Brawley, VS, Bielamowicz, K, Li, XN, Merchant, F, Maitra, S, Sumazin, P, Fuller, G, Kew, Y, Sun, D, Powell, SZ, Ahmed, N, Zhang, N & Pati, D 2014, Journal of Neuro-Oncology, vol 119, no. 1. DOI:

Erratum: Combinational targeting offsets antigen escape and enhances effector functions of adoptively transferred T cells in glioblastoma (Molecular Therapy (2012) 21 (2087-2101) DOI: 10.1038/mt.2013.185)
Hegde, M, Corder, A, Chow, KK, Mukherjee, M, Ashoori, A, Kew, Y, Zhang, YJ, Baskin, DS, Merchant, FA, Brawley, VS, Byrd, TT, Krebs, S, Wu, MF, Liu, H, EHeslop, H, Gottschalk, S, Yvon, E & Ahmed, N 2014, Molecular Therapy, vol 22, no. 5. DOI:

Combinational Targeting offsets antigen escape and enhances effector functions of adoptively transferred T cells in glioblastoma
Hegde, M, Corder, A, Chow, KK, Mukherjee, M, Ashoori, A, Kew, Y, Zhang, YJ, Baskin, DS, Merchant, FA, Brawley, VS, Byrd, TT, Krebs, S, Wu, MF, Liu, H, Heslop, HE, Gottachalk, S, Yvon, E & Ahmed, N 2013, Molecular Therapy, vol 21, no. 11, pp. 2087-2101. DOI:

T cells redirected to EphA2 for the immunotherapy of glioblastoma
Chow, KKH, Naik, S, Kakarla, S, Brawley, VS, Shaffer, DR, Yi, Z, Rainusso, N, Wu, MF, Liu, H, Kew, Y, Grossman, RG, Powell, S, Lee, D, Ahmed, N & Gottschalk, S 2013, Molecular Therapy, vol 21, no. 3, pp. 629-637. DOI:

Generation of polyclonal CMV-specific T cells for the adoptive immunotherapy of glioblastoma
Ghazi, A, Ashoori, A, Hanley, PJ, Brawley, VS, Shaffer, DR, Kew, Y, Powell, SZ, Grossman, R, Grada, Z, Scheurer, ME, Hegde, M, Leen, AM, Bollard, CM, Rooney, CM, Heslop, HE, Gottschalk, S & Ahmed, N 2012, Journal of Immunotherapy, vol 35, no. 2, pp. 159-168. DOI:

Desmoplastic non-infantile ganglioglioma in late adulthood
Rangel-Castilla, L, Kew, Y, Powell, S & Zhang, YJ 2011, Journal of Neuro-Oncology, vol 103, no. 3, pp. 733-737. DOI:

Neuro-Oncology and Cancer Pain
Kew, Y & Edmondson, EA 2010, . in Neurology Secrets. Elsevier, pp. 283-300. DOI:

HER2-specific T cells target primary glioblastoma stem cells and induce regression of autologous experimental tumors
Ahmed, N, Salsman, VS, Kew, Y, Shaffer, D, Powell, S, Zhang, YJ, Grossman, RG, Heslop, HE & Gottschalk, S 2010, Clinical Cancer Research, vol 16, no. 2, pp. 474-485. DOI:

Dissemination of prostate adenocarcinoma to the skull base mimicking giant trigeminal schwannoma: Anatomic relevance of the extradural neural axis component
Gasco, J, Kew, Y, Livingston, A, Rose, J & Zhang, YJ 2009, Skull Base, vol 19, no. 6, pp. 425-430. DOI:

Advances in gene therapy and immunotherapy for brain tumors
Kew, Y & Levin, VA 2003, Current Opinion in Neurology, vol 16, no. 6, pp. 665-670. DOI:

The effect of increased processivity on overall fidelity of human immunodeficiency virus type 1 reverse transcriptase
Rezende, LF, Kew, Y & Prasad, VR 2001, Journal of Biomedical Science, vol 8, no. 2, pp. 197-205. DOI:

Insertions into the ß3-ß4 hairpin loop of HIV-1 reverse transcriptase reveal a role for fingers subdomain in processive polymerization
Kew, Y, Olsen, LR, Japour, AJ & Prasad, VR 1998, Journal of Biological Chemistry, vol 273, no. 13, pp. 7529-7537. DOI:

The nucleoside analog-resistant E89G mutant of human immunodeficiency virus type 1 reverse transcriptase displays a broader cross-resistance that extends to nonnucleoside inhibitors
Kew, Y, Salomon, H, Olsen, LR, Wainberg, MA & Prasad, VR 1996, Antimicrobial Agents and Chemotherapy, vol 40, no. 7, pp. 1711-1714.

Subunit-selective Mutagenesis of Glu-89 Residue in Human Immunodeficiency Virus Reverse Transcriptase: Contribution of p66 and p51 Subunits to Nucleoside Analog Sensitivity, Divalent Cation Preference, and Steady State Kinetic Properties
Kew, Y, Qingbin, S & Prasad, VR 1994, Journal of Biological Chemistry, vol 269, no. 21, pp. 15331-15336.

Expression of human glucocerebrosidase in long-term reconstituted mice following retroviral-mediated gene transfer into hematopoietic stem cells
Correll, PH, Kew, Y, Perry, LK, Brady, RO, Fink, JK & Karlsson, S 1990, Human Gene Therapy, vol 1, no. 3, pp. 277-287.