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Ye Tony Hu, PhD

Associate Professor of Nanomedicine, Institute for Academic Medicine
Associate Member, Research Institute
Houston Methodist
Weill Cornell Medical College

Research Lab


Dr. Tony Hu currently serves as an associate professor in the Department of Nanomedicine at the Houston Methodist Research Institute and the director of the Peptidomic Nanoengineering Core at Houston Methodist Hospital. He is also an assistant professor in the Department of Cell and Developmental Biology at Weill Cornell Medical College of Cornell University (New York). He received his Ph.D. in Biomedical Engineering from the University of Texas at Austin where he focused on developing nanomaterials as biosensors for disease diagnosis. Dr. Hu brings a diverse background that combines Biochemistry, Mass Spectrometry, Nanofabrication, and Biomedical Engineering. He has been working on the development and engineering of nanoporous-silica devices, including their application in discovery and validation of biomarkers for years. Dr. Hu has published more than 30 journal papers, and holds 5 U.S. patents (issued and pending) on these subjects since his facultyship starting from 2011. Dr. Hu also contributed four book chapters on the nanomedicine field, and gave more than 20 invited presentations in many major scientific conferences, seminars around the world. His work has been reported by ABC TV, AACC, Chemical&Engineering News, Science Translational Medicine, Nanowok, Science Daily and etc. Dr. Hu received the Gates Foundation Grand Challenge Explorations Award (2012), Virginia and Ernest Cockrell Junior Faculty Award (2012), HMRI President Award (2013), Golfer Against Cancer Award (2014), and Kostas Cardiovascular Nanomedicine Award (2014). His in-depth knowledge of multiplex-detection method development, which is for sample processing, mass spectrometry, biomarker identification and validation, ideally positions him in a leading role to ensure optimal progress toward the clinical translation of a platform for improved and comprehensive analysis of blood-based biomarkers, with potentially broad clinical applications.

Description of Research

Nanotechnology is a promising tool to improve diagnosis, assess treatment efficacy and design personalized therapies with minimal invasiveness. Dr. Hu's research team is developing integrated mesoporous material based microsystems, semiconductor chips and nanotechnologies for imaging, sensing and regulating cellular processes critical to healthcare, and environmental and defense applications. His current research focuses on developing tools and methods to understand and regulate complex biological networks that are critical to the development of disease, and developing nano-micro fabricated sensors for biomaterial characterization that can be used to improve pre-cancerous lesion detection. Nano-Micro scale science, information, and biomedicine are integrative components of his research, and are used in combinaion with advanced engineering tools to facilitate biomedical studies and develop robust diagnostics for global health initiatives.

Areas Of Expertise

Early disease diagnostics Nanomedicine Nanotechnology
Education & Training

, The University of Texas at Austin

Profiling of cross-functional peptidases regulated circulating peptides in BRCA1 mutant breast cancer
Fan, J, Tea, MKM, Yang, C, Ma, L, Meng, QH, Hu, TY, Singer, CF & Ferrari, M 2016, Journal of Proteome Research, vol 15, no. 5, pp. 1534-1545. DOI:

Intergenic variable-number tandem-repeat polymorphism upstream of rocA alters toxin production and enhances virulence in Streptococcus pyogenes
Zhu, L, Olsen, RJ, Horstmann, N, Shelburne, SA, Fan, J, Hu, T & Musser, JM 2016, Infection and Immunity, vol 84, no. 7, pp. 2086-2093. DOI:

One-pot synthesis of pH-responsive hybrid nanogel particles for the intracellular delivery of small interfering RNA
Khaled, SZ, Cevenini, A, Yazdi, IK, Parodi, A, Evangelopoulos, M, Corbo, C, Scaria, S, Hu, Y, Haddix, SG, Corradetti, B, Salvatore, F & Tasciotti, E 2016, Biomaterials, vol 87, pp. 57-68. DOI:

Sequential co-delivery of miR-21 inhibitor followed by burst release doxorubicin using NIR-responsive hollow gold nanoparticle to enhance anticancer efficacy
Ren, Y, Wang, R, Gao, L, Li, K, Zhou, X, Guo, H, Liu, C, Han, D, Tian, J, Ye, Q, Hu, YT, Sun, D, Yuan, X & Zhang, N 2016, Journal of Controlled Release, vol 228, pp. 74-86. DOI:

Identification and quantitation of lipid C=C location isomers: A shotgun lipidomics approach enabled by photochemical reaction
Ma, X, Chong, L, Tian, R, Shi, R, Hu, TY, Ouyang, Z & Xia, Y 2016, Proceedings of the National Academy of Sciences of the United States of America, vol 113, no. 10, pp. 2573-2578. DOI:

A Micro/Nano Composite for Combination Treatment of Melanoma Lung Metastasis
Mi, Y, Mu, C, Wolfram, J, Deng, Z, Hu, T, Liu, X, Blanco, E, Shen, H & Ferrari, M 2016, Advanced Healthcare Materials. DOI:

Hepcidin levels in hyperprolactinemic women monitored by nanopore thin film based assay: Correlation with pregnancy-associated hormone prolactin
Wang, J, Liu, G, Xu, Z, Dai, J, Song, P, Shi, J, Hu, Y, Hu, Z, Nie, G, Chang, YZ & Zhao, Y 2015, Nanomedicine: Nanotechnology, Biology, and Medicine, vol 11, no. 4, pp. 871-878. DOI:

Circulating Peptidome to Indicate the Tumor-resident Proteolysis
Deng, Z, Li, Y, Fan, J, Wang, G, Li, Y, Zhang, Y, Cai, G, Shen, H, Ferrari, M & Hu, TY 2015, Scientific Reports, vol 5, 9327. DOI:

Antibody-free detection of Mycobacterium tuberculosis antigen using customized nanotraps
Wu, HJ, Li, Y, Fan, J, Deng, Z, Hu, Z, Liu, X, Graviss, EA, Ferrari, M, Ma, X & Hu, Y 2014, Analytical Chemistry, vol 86, no. 4, pp. 1988-1996. DOI:

Lab-on-chip device for single cell trapping and analysis
Shah, P, Zhu, X, Chen, C, Hu, Y & Li, CZ 2014, Biomedical Microdevices, vol 16, no. 1, pp. 35-41. DOI:

RFID tag helix antenna sensors for wireless drug dosage monitoring
Huang, H, Zhao, P, Chen, PY, Ren, Y, Liu, X, Ferrari, M, Hu, Y & Akinwande, D 2014, IEEE Journal of Translational Engineering in Health and Medicine, vol 2, no. 1, 1700108. DOI:

MiR-205 acts as a tumour radiosensitizer by targeting ZEB1 and Ubc13
Zhang, P, Wang, L, Rodriguez-Aguayo, C, Yuan, Y, Debeb, BG, Chen, D, Sun, Y, You, MJ, Liu, Y, Dean, DC, Woodward, WA, Liang, H, Yang, X, Lopez-Berestein, G, Sood, AK, Hu, Y, Ang, KK, Chen, J & Ma, L 2014, Nature Communications, vol 5, 5671. DOI:

Multidisciplinary efforts driving translational theranostics
Hu, TY 2014, Theranostics, vol 4, no. 12, pp. 1209-1210. DOI:

ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1
Zhang, P, Wei, Y, Wang, L, Debeb, BG, Yuan, Y, Zhang, J, Yuan, J, Wang, M, Chen, D, Sun, Y, Woodward, WA, Liu, Y, Dean, DC, Liang, H, Hu, Y, Ang, KK, Hung, MC, Chen, J & Ma, L 2014, Nature Cell Biology, vol 16, no. 9, pp. 864-875. DOI:

Nanotechnologies in glycoproteomics
Zhao, H, Li, Y & Hu, Y 2014, Clinical Proteomics, vol 11, no. 1, 21. DOI:

Nanopore film based enrichment and quantification of low abundance hepcidin from human bodily fluids
Fan, J, Niu, S, Dong, A, Shi, J, Wu, HJ, Fine, DH, Tian, Y, Zhou, C, Liu, X, Sun, T, Anderson, GJ, Ferrari, M, Nie, G, Hu, Y & Zhao, Y 2014, Nanomedicine: Nanotechnology, Biology, and Medicine, vol 10, no. 5, pp. 879-888. DOI:

Circulating proteolytic products of carboxypeptidase N for early detection of breast cancer
Li, Y, Li, Y, Chen, T, Kuklina, AS, Bernard, P, Esteva, FJ, Shen, H, Ferrari, M & Hu, Y 2014, Clinical Chemistry, vol 60, no. 1, pp. 233-242. DOI:

Bacteriophage associated silicon particles: Design and characterization of a novel theranostic vector with improved payload carrying potential
Srinivasan, S, Alexander, JF, Driessen, WH, Leonard, F, Ye, H, Liu, X, Arap, W, Pasqualini, R, Ferrari, M & Godin, B 2013, Journal of Materials Chemistry B, vol 1, no. 39, pp. 5218-5229. DOI:

Ciliated micropillars for the microfluidic-based isolation of nanoscale lipid vesicles
Wang, Z, Wu, HJ, Fine, D, Schmulen, J, Hu, Y, Godin, B, Zhang, JXJ & Liu, X 2013, Lab on a Chip - Miniaturisation for Chemistry and Biology, vol 13, no. 15, pp. 2879-2882. DOI:

Serum peptidomic biomarkers for pulmonary metastatic melanoma identified by means of a nanopore-based assay
Fan, J, Huang, Y, Finoulst, I, Wu, HJ, Deng, Z, Xu, R, Xia, X, Ferrari, M, Shen, H & Hu, Y 2013, Cancer Letters, vol 334, no. 2, pp. 202-210. DOI: