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Xuewu Liu, PhD

Associate Professor Nanomedicine, Institute for Academic Medicine
Associate Member, Research Institute
Houston Methodist


Dr. Xuewu Liu worked as an engineer in the optics industry for two years before undertaking postdoctoral training at the Indiana Center for Biological Microscopy at IUPUI Indianapolis. He then joined Ohio State University as a senior research associate in nanomedicine. He was appointed assistant professor of nanomedicine and biomedical engineering at the University of Texas Health Science Center in Houston in 2006. In 2010, Dr. Liu joined to The Methodist Hospital Research Institute, to direct the nanoengineering core.

Dr. Xuewu Liu is a leading scientist in silicon nanotechnology, with extensive experience in materials science, optics, microfabrication and nanomedicine. He directs research and development of silicon based biomedical nanotechnology, and coordinates a nanoengineering team to support biomedical research at the institute levels. The nanomedicine platforms he has developed include porous silicon particles, nanowire barcodes, an implantable nanochannel delivery system, nanowire enhanced nanofluidic devices, and nanoporous proteomic chips. Dr. Liu had been issued 8 US patents, and published over 100 peer-reviewed journal papers, of which >20 were highlighted as journal cover articles.

Description of Research

Dr. Liu’s research focus is the development of silicon based nanotechnology platforms for prevention, diagnosis and treatment of human disease. His current interests include mass production of porous silicon particles, surface chemistry of porous silicon, nanowire theranostic platforms, multifunctional nanoparticles, and microfluidics devices for isolation and analysis of exosomes.

Areas Of Expertise

Silicon nanotechnology Drug delivery nanoparticles Theranostics Biological microfluidics
Education & Training

, Heart and Lung Research Institute
, Indiana Center for Biological Microscopy, Indianapolis, IN
, Jilin University
, Kent State University

Enzyme-responsive multistage vector for drug delivery to tumor tissue
Mi, Y, Wolfram, J, Mu, C, Liu, X, Blanco, E, Shen, H & Ferrari, M 2016, Pharmacological Research, vol 113, pp. 92-99. DOI:

In situ growth of fluorescent silicon nanocrystals in a monolithic microcapsule as a photostable, versatile platform
Zhu, G, Huang, Y, Bhave, G, Wang, Y, Hu, Z & Liu, X 2016, Nanoscale, vol 8, no. 34, pp. 15645-15657. DOI:

A pyruvate decarboxylase-mediated therapeutic strategy for mimicking yeast metabolism in cancer cells
Scott, B, Shen, J, Nizzero, S, Boom, K, Persano, S, Mi, Y, Liu, X, Zhao, Y, Blanco, E, Shen, H, Ferrari, M & Wolfram, J 2016, Pharmacological Research, vol 111, pp. 413-421. DOI:

Enhanced performance of macrophage-encapsulated nanoparticle albumin-bound-paclitaxel in hypo-perfused cancer lesions
Leonard, F, Curtis, LT, Yesantharao, P, Tanei, T, Alexander, JF, Wu, M, Lowengrub, J, Liu, X, Ferrari, M, Yokoi, K, Frieboes, HB & Godin, B 2016, Nanoscale, vol 8, no. 25, pp. 12544-12552. DOI:

A pyruvate decarboxylase-mediated therapeutic strategy for mimicking yeast metabolism in cancer cells
Scott, B, Shen, J, Nizzero, S, Boom, K, Persano, S, Mi, Y, Liu, X, Zhao, Y, Blanco, E, Shen, H, Ferrari, M & Wolfram, J 2016, Pharmacological Research.

In Situ Reductive Synthesis of Structural Supported Gold Nanorods in Porous Silicon Particles for Multifunctional Nanovectors
Zhu, G, Liu, JT, Wang, Y, Zhang, D, Guo, Y, Tasciotti, E, Hu, Z & Liu, X 2016, ACS Applied Materials and Interfaces, vol 8, no. 18, pp. 11881-11891. DOI:

An injectable nanoparticle generator enhances delivery of cancer therapeutics
Xu, R, Zhang, G, Mai, J, Deng, X, Segura-Ibarra, V, Wu, S, Shen, J, Liu, H, Hu, Z, Chen, L, Huang, Y, Koay, E, Huang, Y, Liu, J, Ensor, JE, Blanco, E, Liu, X, Ferrari, M & Shen, H 2016, Nature Biotechnology, vol 34, no. 4, pp. 414-418. DOI:

IL-4 Release from a Biomimetic Scaffold for the Temporally Controlled Modulation of Macrophage Response
Minardi, S, Corradetti, B, Taraballi, F, Byun, JH, Cabrera, F, Liu, X, Ferrari, M, Weiner, BK & Tasciotti, E 2016, Annals of Biomedical Engineering, pp. 1-12. DOI:

Cell source determines the immunological impact of biomimetic nanoparticles
Evangelopoulos, M, Parodi, A, Martinez, JO, Yazdi, IK, Cevenini, A, van de Ven, AL, Quattrocchi, N, Boada, C, Taghipour, N, Corbo, C, Brown, BS, Scaria, S, Liu, X, Ferrari, M & Tasciotti, E 2016, Biomaterials, vol 82, pp. 168-177. DOI:

Distinct molecular abnormalities underlie unique clinical features of essential thrombocythemia in children
Fu, R, Liu, D, Cao, Z, Zhu, S, Li, H, Su, H, Zhang, L, Xue, F, Liu, X, Zhang, X, Cheng, T, Yang, R & Zhang, L 2016, Leukemia, vol 30, no. 3, pp. 746-749. DOI:

Redirecting transport of nanoparticle albumin-bound paclitaxel to macrophages enhances therapeutic efficacy against liver metastases
Tanei, T, Leonard, F, Liu, X, Alexander, JF, Saito, Y, Ferrari, M, Godin, B & Yokoi, K 2016, Cancer Research, vol 76, no. 2, pp. 429-439.

A Micro/Nano Composite for Combination Treatment of Melanoma Lung Metastasis
Mi, Y, Mu, C, Wolfram, J, Deng, Z, Hu, T, Liu, X, Blanco, E, Shen, H & Ferrari, M 2016, Advanced Healthcare Materials. DOI:

Microfluidic interactions between red blood cells and drug carriers by image analysis techniques
DApolito, R, Taraballi, F, Minardi, S, Liu, X, Caserta, S, Cevenini, A, Tasciotti, E, Tomaiuolo, G & Guido, S 2016, Medical Engineering and Physics, vol 38, no. 1, pp. 17-23. DOI:

Multistage vector delivery of sulindac and silymarin for prevention of colon cancer
Scavo, MP, Gentile, E, Wolfram, J, Gu, J, Barone, M, Evangelopoulos, M, Martinez, JO, Liu, X, Celia, C, Tasciotti, E, Vilar, E & Shen, H 2015, Colloids and Surfaces B: Biointerfaces, vol 136, pp. 694-703. DOI:

Red blood cells affect the margination of microparticles in synthetic microcapillaries and intravital microcirculation as a function of their size and shape
DApolito, R, Tomaiuolo, G, Taraballi, F, Minardi, S, Kirui, D, Liu, X, Cevenini, A, Palomba, R, Ferrari, M, Salvatore, F, Tasciotti, E & Guido, S 2015, Journal of Controlled Release, vol 217, pp. 263-272. DOI:

PLGA-Mesoporous Silicon Microspheres for the in Vivo Controlled Temporospatial Delivery of Proteins
Minardi, S, Pandolfi, L, Taraballi, F, De Rosa, E, Yazdi, IK, Liu, X, Ferrari, M & Tasciotti, E 2015, ACS Applied Materials and Interfaces, vol 7, no. 30, pp. 16364-16373. DOI:

Porous Silicon Microparticle Potentiates Anti-Tumor Immunity by Enhancing Cross-Presentation and Inducing Type I Interferon Response
Xia, X, Mai, J, Xu, R, Perez, JET, Guevara, ML, Shen, Q, Mu, C, Tung, HY, Corry, DB, Evans, SE, Liu, X, Ferrari, M, Zhang, Z, Li, XC, Wang, RF & Shen, H 2015, Cell Reports, vol 11, no. 6, pp. 957-966. DOI:

Biodegradable silicon nanoneedles delivering nucleic acids intracellularly induce localized in vivo neovascularization
Chiappini, C, De Rosa, E, Martinez, JO, Liu, X, Steele, J, Stevens, MM & Tasciotti, E 2015, Nature Materials, vol 14, no. 5, doi:10.1038/nmat4249, pp. 532-539. DOI:

Silencing of tumor necrosis factor receptor-1 in human lung microvascular endothelial cells using particle platforms for siRNA delivery
Bai, L, Andersson, HA, McConnell, KI, Chan, DL, Hernandez, M, Gonzalez, J, Liu, X, Francesca, SL, Sakamoto, JH & Serda, RE 2015, Current Drug Targets, vol 16, no. 13, A013, pp. 1531-1539.

Multistage nanovectors enhance the delivery of free and encapsulated drugs
Martinez, JO, Evangelopoulos, M, Bhavane, R, Acciardo, S, Salvatore, F, Liu, X, Ferrari, M & Tasciotti, E 2015, Current Drug Targets, vol 16, no. 14, pp. 1582-1590.