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Xuefeng Xia, PhD

Assistant Research Professor of Nanomedicine, Institute for Academic Medicine
Assistant Research Member, Research Institute
Houston Methodist


After completing his postdoctoral training at Baylor College of Medicine in 2002, Dr. Xuefeng Xia joined the University of Texas Health Science Center at Houston as an instructor. Dr. Xia was appointed to assistant professor of medicine at the University of Texas Health Science Center in 2006. He was appointed assistant member at the Houston Methodist Research Institute in 2008.

Dr. Xia also holds an adjunct professorship at The Guangzhou Medical College in China. His research projects focus on liver and kidney disease function and disease states, and span the Genomic Medicine and Diabetes & Metabolic Disease research programs at the Research Institute. Dr. Xia is also a member of American Gastroenterology Association and The Endocrine Society.

Description of Research

Dr. Xia’s research defines the role and molecular mechanisms of nuclear hormone receptors in the liver and kidney. His lab uses multidisciplinary state-of-the-art technologies including genetically modified mouse models, genomic array, proteomics, metabolomics, 3-D cultures, and molecular, cellular and histological methodologies.

The three key goals of Dr. Xia’s research are:
-To use manipulation of nuclear receptor function to control bile physiology in cholestatic liver disease, gallstone formation, and cholangiocarcinoma
-To use liver secreted hormone to influence metabolic pathways important in lipid and glucose meta-bolism, lipolysis and regulation weight.
-To develop a method to reproducibly isolate highly-enriched podocytes from mouse glomeruli to identify novel podocyte genes and pathways that are altered by kidney injuries

Areas Of Expertise

Nuclear receptors Diabetes Liver Kidney Genomic medicine
Education & Training

, Hunan Medical University, Changsha, Hunan

Application of circulating tumor DNA as a non-invasive tool for monitoring the progression of colorectal cancer
Zhou, J, Chang, L, Guan, Y, Yang, L, Xia, X, Cui, L, Yi, X & Lin, G 2016, PLoS ONE, vol 11, no. 7, e0159708. DOI:

Klotho protects against indoxyl sulphate-induced myocardial hypertrophy
Yang, K, Wang, C, Nie, L, Zhao, X, Gu, J, Guan, X, Wang, S, Xiao, T, Xu, X, He, T, Xia, X, Wang, J & Zhao, J 2015, Journal of the American Society of Nephrology, vol 26, no. 10, pp. 2434-2446. DOI:

The cell cycle regulator 14-3-3s opposes and reverses cancer metabolic reprogramming
Phan, L, Chou, PC, Velazquez-Torres, G, Samudio, I, Parreno, K, Huang, Y, Tseng, C, Vu, T, Gully, C, Su, CH, Wang, E, Chen, J, Choi, HH, Fuentes-Mattei, E, Shin, JH, Shiang, C, Grabiner, B, Blonska, M, Skerl, S, Shao, Y, Cody, D, Delacerda, J, Kingsley, C, Webb, D, Carlock, C, Zhou, Z, Hsieh, YC, Lee, J, Elliott, A, Ramirez, M, Bankson, J, Hazle, J, Wang, Y, Li, L, Weng, S, Rizk, N, Wen, YY, Lin, X, Wang, H, Wang, H, Zhang, A, Xia, X, Wu, Y, Habra, M, Yang, W, Pusztai, L, Yeung, SC & Lee, MH 2015, Nature Communications, vol 6, 7530. DOI:

Hepatic estrogen receptor a improves hepatosteatosis through upregulation of small heterodimer partner
Wang, X, Lu, Y, Wang, E, Zhang, Z, Xiong, X, Zhang, H, Lu, J, Zheng, S, Yang, J, Xia, X, Yang, S & Li, X 2015, Journal of Hepatology, vol 63, no. 1, 5577, pp. 183-190. DOI:

Thyroid-stimulating hormone regulates hepatic bile acid homeostasis via SREBP-2/HNF-4a/CYP7A1 axis
Song, Y, Xu, C, Shao, S, Liu, J, Xing, W, Xu, J, Qin, C, Li, C, Hu, B, Yi, S, Xia, X, Zhang, H, Zhang, X, Wang, T, Pan, W, Yu, C, Wang, Q, Lin, X, Wang, L, Gao, L & Zhao, J 2015, Journal of Hepatology, vol 62, no. 5, pp. 1171-1179. DOI:

Haemophagocytic lymphohistiocytosis in inflammatory bowel disease with virus infection
Li, Y, Xia, X, Zhang, J, Song, Z, Zhou, L, Zhang, Y, Huang, Y, Shi, Y, Quigley, EMM & Ding, S 2015, Przeglad Gastroenterologiczny, vol 10, no. 2, pp. 78-82. DOI:

Thyroid hormone receptor regulates most genes independently of fibroblast growth factor 21 in liver
Zhang, A, Sieglaff, DH, York, JP, Suh, JH, Ayers, SD, Winnier, GE, Kharitonenkov, A, Pin, C, Zhang, P, Webb, P & Xia, X 2015, Journal of Endocrinology, vol 224, no. 3, pp. 289-301. DOI:

Recruited metastasis suppressor NM23-H2 attenuates expression and activity of peroxisome proliferator-activated receptor d (PPARd) in human cholangiocarcinoma
He, F, York, JP, Burroughs, SG, Qin, L, Xia, J, Chen, D, Quigley, EM, Webb, P, LeSage, GD & Xia, X 2015, Digestive and Liver Disease, vol 47, no. 1, pp. 62-67. DOI:

Integration of platinum nanoparticles with a volumetric bar-chart chip for biomarker assays
Song, Y, Xia, X, Wu, X, Wang, P & Qin, L 2014, Angewandte Chemie - International Edition, vol 53, no. 46, pp. 12451-12455. DOI:

Gain-of-Function Mutant p53 Promotes Cell Growth and Cancer Cell Metabolism via Inhibition of AMPK Activation
Zhou, G, Wang, J, Zhao, M, Xie, TX, Tanaka, N, Sano, D, Patel, AA, Ward, AM, Sandulache, VC, Jasser, SA, Skinner, HD, Fitzgerald, AL, Osman, AA, Wei, Y, Xia, X, Songyang, Z, Mills, GB, Hung, MC, Caulin, C, Liang, J & Myers, JN 2014, Molecular Cell, vol 54, no. 6, pp. 960-974. DOI:

EphA2 promotes epithelial-mesenchymal transition through the Wnt/ß-catenin pathway in gastric cancer cells
Huang, J, Xiao, D, Li, G, Ma, J, Chen, P, Yuan, W, Hou, F, Ge, J, Zhong, M, Tang, Y, Xia, X & Chen, Z 2014, Oncogene, vol 33, no. 21, pp. 2737-2747. DOI:

Drosophila TRPML forms PI(3,5)P2-activated cation channels in both endolysosomes and plasma Membrane
Feng, X, Huang, Y, Lu, Y, Xiong, J, -On Wong, C, Yang, P, Xia, J, Chen, D, Du, G, Venkatachalam, K, Xia, X & Zhu, MX 2014, Journal of Biological Chemistry, vol 289, no. 7, pp. 4262-4272. DOI:

Differential mechanisms of action of the mucolipin synthetic agonist, ML-SA1, on insect TRPML and mammalian TRPML1
Feng, X, Xiong, J, Lu, Y, Xia, X & Zhu, MX 2014, Cell Calcium, vol 56, no. 6, pp. 446-456. DOI:

FXR-induced secretion of FGF15/19 inhibits CYP27 expression in cholangiocytes through p38 kinase pathway
Jung, D, York, JP, Wang, L, Yang, C, Zhang, A, Francis, HL, Webb, P, McKeehan, WL, Alpini, G, LeSage, GD, Moore, DD & Xia, X 2014, Pflugers Archiv European Journal of Physiology, vol 466, no. 5, pp. 1011-1019. DOI:

Yin Yang 1 promotes hepatic steatosis through repression of farnesoid X receptor in obese mice
Lu, Y, Ma, Z, Zhang, Z, Xiong, X, Wang, X, Zhang, H, Shi, G, Xia, X, Ning, G & Li, X 2014, Gut, vol 63, no. 1, pp. 170-178. DOI:

Cigarette smoking is associated with human semen quality in synergy with functional NRF2 polymorphisms
Yu, B, Chen, J, Liu, D, Zhou, H, Xiao, W, Xia, X & Huang, Z 2013, Biology of Reproduction, vol 89, no. 1, 5. DOI:

Ablation of LGR4 promotes energy expenditure by driving white-to-brown fat switch
Wang, J, Liu, R, Wang, F, Hong, J, Li, X, Chen, M, Ke, Y, Zhang, X, Ma, Q, Wang, R, Shi, J, Cui, B, Gu, W, Zhang, Y, Zhang, Z, Wang, W, Xia, X, Liu, M & Ning, G 2013, Nature Cell Biology.

Ablation of LGR4 promotes energy expenditure by driving white-to-brown fat switch.
Wang, J, Liu, R, Wang, F, Hong, J, Li, X, Chen, M, Ke, Y, Zhang, X, Ma, Q, Wang, R, Shi, J, Cui, B, Gu, W, Zhang, Y, Zhang, Z, Wang, W, Xia, X, Liu, M & Ning, G 2013, Nature Cell Biology, vol 15, no. 12, pp. 1455-1463. DOI:

Androgens regulate prostate cancer cell growth via an AMPK-PGC-1a-mediated metabolic switch
Tennakoon, JB, Shi, Y, Han, JJ, Tsouko, E, White, MA, Burns, AR, Zhang, A, Xia, X, Ilkayeva, OR, Xin, L, Ittmann, MM, Rick, FG, Schally, AV & Frigo, DE 2013, Oncogene. DOI:

Antisense oligonucleotide suppression of human IGF-1R inhibits the growth and survival of in vitro cultured epithelial ovarian cancer cells
Tang, J, Li, J, Zeng, G, Tang, Y, Tian, W, He, J, York, JP & Xia, X 2013, Journal of Ovarian Research, vol 6, no. 1, 71. DOI: