William A. Zoghbi, MD, FASE, FAHA, MACC

Elkins Family Distinguished Chair in Cardiac Health, DeBakey Heart & Vascular Center
Chair, Department of Cardiology
Professor of Cardiology, Institute for Academic Medicine
Full Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Biography

William A. Zoghbi is the Elkins Family Distinguished Chair in Cardiac Health, Chairman of the Department of Cardiology at The Houston Methodist DeBakey Heart & Vascular Center and Professor of Medicine at Weill Cornell Medical College and the Institute of Academic Medicine.

Dr. Zoghbi is a renowned leader in cardiology, echocardiography, and cardiac imaging. He has developed new techniques to evaluate heart function and valve disorders without resorting to invasive procedures. These accomplishments led him to preside over the development of national and international guidelines for evaluating heart valves. He is known for his research on ischemic heart disease, myocardial function and hibernation, and for developing echocardiographic techniques to evaluate valvular dynamics and measure valvular regurgitation. Dr. Zoghbi has authored more than 300 original publications and has been invited to lecture on his work at every major cardiology conference around the globe.

Always looking forward, Dr. Zoghbi is dedicated to cardiovascular education. He is a much sought-after mentor and has trained over 100 cardiology fellows in advanced cardiovascular imaging. Many of his former students now hold leadership positions worldwide.  Dr. Zoghbi’s commitment to physician training and education is evident at the national level: In 2004, the American Society of Echocardiography presented him with the Richard Popp Excellence in Teaching Award.  Moreover, he co-chaired the American College of Cardiology committee that wrote a monograph on how best to train the new generation of cardiologists in cardiovascular imaging.

As an advocate for scientific communication, Dr. Zoghbi lends his expertise to several journals. He has served as associate editor of Circulation and is currently a senior editor of JACC Cardiovascular Imaging, the global health section editor for the Journal of the American College of Cardiology, and an editorial board member of Global Heart.

Description of Research

Dr. Zoghbi´s research has focused on cardiovascular imaging, particularly echocardiography, refining its techniques for better diagnosis and treatment of cardiovascular disease.  He has developed methods for evaluation of valvular function, quantitation of ventricular function, and detection of myocardial viability in patients with ischemic ventricular dysfunction. More recently, in collaboration with mathematicians at the University of Houston, Dr. Zoghbi has directed his laboratory’s efforts to better understand cardiac valve structure and function and to improve quantitation of artificial valve function using in vitro modeling and multimodality imaging. 

Areas Of Expertise

Echocardiography Valvular function Ventricular function Myocardial hibernation
Education & Training

Clinical Fellowship , Baylor College of Medicine
Residency , Baylor College of Medicine
Internship , University of Texas, Medical Branch
MD , Meharry Medical College School of Medicine
Publications

Recommendations for Noninvasive Evaluation of Native Valvular Regurgitation: A Report from the American Society of Echocardiography Developed in Collaboration with the Society for Cardiovascular Magnetic Resonance
Zoghbi, WA, Adams, D, Bonow, RO, Enriquez-Sarano, M, Foster, E, Grayburn, PA, Hahn, RT, Han, Y, Hung, J, Lang, RM, Little, SH, Shah, DJ, Shernan, S, Thavendiranathan, P, Thomas, JD & Weissman, NJ 2017, Journal of the American Society of Echocardiography, vol 30, no. 4, pp. 303-371. DOI:

Doppler Echocardiography for the Estimation of LV Filling Pressure in Patients With Mitral Annular Calcification
Abudiab, MM, Chebrolu, LH, Schutt, RC, Nagueh, SF & Zoghbi, WA 2017, JACC. Cardiovascular imaging. DOI:

Global Chronic Disease: The Role of the American College of Cardiology
Harold, JG, Kovach, N & Zoghbi, WA 2016, Global Heart, vol 11, no. 4, pp. 429-431. DOI:

Cardiac Remodeling in American-Style Football Players: Field Position Matters
Zoghbi, WA 2016, JACC: Cardiovascular Imaging, vol 9, no. 12, pp. 1377-1379. DOI:

The Future of Cardiac Imaging: Report of a Think Tank Convened by the American College of Cardiology
Douglas, PS, Cerqueira, MD, Berman, DS, Chinnaiyan, K, Cohen, MS, Lundbye, JB, Patel, RAG, Sengupta, PP, Soman, P, Weissman, NJ, Wong, TC, Asch, F, Bateman, TM, Berman, DS, Biesbrock, G, Brinker, J, Brophy, D, Cerqueira, M, Chinnaiyan, K, Cohen, M, Dilsizian, V, Douglas, PS, Dudley, J, Epstein, F, Gillam, L, Lundbye, J, McCallister, B, Narula, J, Patel, RAG, Reynolds, D, Schoepf, UJ, Sengupta, PP, Shah, N, Soman, P, Udelson, JE, Valeti, US, Walsh, MN, Ward, RP, Weigold, WG, Weissman, NJ, White, RD, Wolinsky, D, Wong, TC & Zoghbi, WA 2016, JACC: Cardiovascular Imaging, vol 9, no. 10, pp. 1211-1223. DOI:

Pannus of Mitral Valve Prosthesis Causing Left Ventricular Outflow Tract Obstruction
Abudiab, MM, McKay, J, Deavers, M, Zoghbi, WA & Chang, SM 2016, Houston Methodist DeBakey Cardiovascular Journal, vol 12, no. 3, pp. 183. DOI:

The Heart of 25 by 25: Achieving the Goal of Reducing Global and Regional Premature Deaths From Cardiovascular Diseases and Stroke: A Modeling Study From the American Heart Association and World Heart Federation
Sacco, RL, Roth, GA, Reddy, KS, Arnett, DK, Bonita, R, Gaziano, TA, Heidenreich, PA, Huffman, MD, Mayosi, BM, Mendis, S, Murray, CJL, Perel, P, Piñeiro, DJ, Smith, SC, Taubert, KA, Wood, DA, Zhao, D & Zoghbi, WA 2016, Circulation. DOI:

Novel parameters of global and regional mitral annulus geometry in man: Comparison between normals and organic mitral regurgitation, before and after mitral valve repair
Ben Zekry, S, Jain, S, Alexander, SK, Li, Y, Aggarwal, A, Jajoo, A, Little, SH, Lawrie, GM, Azencott, R & Zoghbi, WA 2016, European Heart Journal Cardiovascular Imaging, vol 17, no. 4, pp. 447-457. DOI:

Implementing Multimodality Imaging in the Future
Chandrashekhar, Y, Dilsizian, V, Kramer, CM, Marwick, T, Min, JK, Shaw, L, Zoghbi, WA & Narula, J 2016, JACC. Cardiovascular imaging, vol 9, no. 2, pp. 91-8. DOI:

One Hundred Percent Reparability of Degenerative Mitral Regurgitation: Intermediate-Term Results of a Dynamic Engineered Approach
Lawrie, GM , Zoghbi, W , Little, S , Shah, D, Ben-Zekry, Z, Earle, N & Earle, E 2016, Annals of Thoracic Surgery, vol 101, no. 2. DOI:

Comparative Assessment of Mitral Regurgitation Severity by Transthoracic Echocardiography and Cardiac Magnetic Resonance Using an Integrative and Quantitative Approach
Lopez-Mattei, JC, Ibrahim, H, Shaikh, KA, Little, SH, Shah, DJ, Maragiannis, D & Zoghbi, WA 2016, American Journal of Cardiology, vol 117, no. 2, pp. 264-70. DOI:

The Heart of 25 by 25: Achieving the Goal of Reducing Global and Regional Premature Deaths From Cardiovascular Diseases and Stroke. A Modeling Study From the American Heart Association and World Heart Federation
Sacco, RL, Roth, GA, Reddy, KS, Arnett, DK, Bonita, R, Gaziano, TA, Heidenreich, PA, Huffman, MD, Mayosi, BM, Mendis, S, Murray, CJL, Perel, P, Piñeiro, DJ, Smith, SC, Taubert, KA, Wood, DA, Zhao, D & Zoghbi, WA 2016, Global Heart. DOI:

Patient-specific quantitation of mitral valve strain by computer analysis of three-dimensional echocardiography: A pilot study
Ben Zekry, S, Freeman, J, Jajoo, A, He, J, Little, SH, Lawrie, GM, Azencott, R & Zoghbi, WA 2016, Circulation. Cardiovascular imaging, vol 9, no. 1, e003254. DOI:

Low-Gradient Severe Aortic Stenosis With Preserved Ventricular Function: Trust But Verify
Zoghbi, WA 2015, Journal of the American College of Cardiology, vol 66, no. 23, pp. 2604-2606. DOI:

Replicating Patient-Specific Severe Aortic Valve Stenosis with Functional 3D Modeling
Maragiannis, D, Jackson, MS, Igo, SR, Schutt, RC, Connell, P, Grande-Allen, J, Barker, CM, Chang, SM, Reardon, MJ, Zoghbi, WA & Little, SH 2015, Circulation: Cardiovascular Imaging, vol 8, no. 10, e003626. DOI:

Myocardial viability and remodeling: Does size matter?
Zoghbi, WA & Narula, J 2015, JACC: Cardiovascular Imaging, vol 8, no. 10, pp. 1235-1237. DOI:

Velocity Acceleration in Aortic Stenosis Revisited
Zoghbi, WA 2015, JACC: Cardiovascular Imaging, vol 8, no. 7, pp. 776-778. DOI:

Role of Imaging in the Evaluation of Patients at Risk for Sudden Cardiac Death Genotype-Phenotype Intersection
Nagueh, SF & Zoghbi, WA 2015, JACC: Cardiovascular Imaging, vol 8, no. 7, pp. 828-845. DOI:

Detection of LA and LAA Thrombus by CMR in Patients Referred for Pulmonary Vein Isolation
Kitkungvan, D, Nabi, F, Ghosn, MG, Dave, AS, Quinones, M, Zoghbi, WA, Valderrabano, M & Shah, DJ 2015, JACC: Cardiovascular Imaging. DOI:

Functional Assessment of Bioprosthetic Aortic Valves by CMR
Maragiannis, D, Jackson, MS, Flores-Arredondo, JH, Autry, K, Schutt, RC, Alvarez, PA, Zoghbi, WA, Shah, DJ & Little, SH 2015, JACC: Cardiovascular Imaging. DOI: