William G. Ondo, MD

Professor of Neurology, Institute for Academic Medicine
Full Clinical Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Dr. William G. Ondo is the director of the Movement Disorders Clinic at the Houston Methodist Neurological Institute. Dr. Ondo has been in practice for nearly 20 years and specializes in diagnosis, treatment and research of Parkinson’s disease, essential tremors, the use of botulinum toxins in treating movement disorders, and restless legs syndrome.

Dr. Ondo earned his medical degree from the Medical College of Virginia before completing an internship at the University of North Carolina Hospital, a neurology residency at Duke University, and a movement disorders fellowship at the Baylor College of Medicine. He is board certified by the American Board of Psychiatry and Neurology in adult neurology and sleep medicine. He has authored more than 250 original articles and book chapters as well as edited two books on movement disorders. He currently serves as the president of the Tremor Research Group.

Areas Of Expertise

Ataxia Parkinson's disease Dystonia Essential tremor Restless legs

Psychiatric associations of adult-onset focal dystonia phenotypes
Berman, BD, Junker, J, Shelton, E, Sillau, SH, Jinnah, HA, Perlmutter, JS, Espay, AJ, Jankovic, J, Vidailhet, M, Bonnet, C, Ondo, W, Malaty, IA, Rodríguez, R, McDonald, WM, Marsh, L, Zurowski, M, Bäumer, T & Brüggemann, N 2017, Journal of neurology, neurosurgery, and psychiatry, vol 88, no. 7, pp. 595-602. DOI: 10.1136/jnnp-2016-315461

Randomized controlled trial of deutetrabenazine for tardive dyskinesia the ARM-TD study
Fernandez, HH, Factor, SA, Hauser, RA, Jimenez-Shahed, J, Ondo, WG, Jarskog, LF, Meltzer, HY, Woods, SW, Bega, D, LeDoux, MS, Shprecher, DR, Davis, C, Davis, MD, Stamler, D & Anderson, KE 2017, Neurology, vol 88, no. 21, pp. 2003-2010. DOI: 10.1212/WNL.0000000000003960

Deutetrabenazine for treatment of involuntary movements in patients with tardive dyskinesia (AIM-TD): A double-blind, randomised, placebo-controlled, phase 3 trial
Anderson, KE, Stamler, D, Davis, MD, Factor, SA, Hauser, RA, Isojärvi, J, Jarskog, LF, Jimenez-Shahed, J, Kumar, R, McEvoy, JP, Ochudlo, S, Ondo, WG & Fernandez, HH 2017, The Lancet Psychiatry. DOI: 10.1016/S2215-0366(17)30236-5

Thalamic deep brain stimulation for orthostatic tremor: A multicenter international registry
Merola, A, Fasano, A, Hassan, A, Ostrem, JL, Contarino, MF, Lyons, M, Krauss, JK, Wolf, ME, Klassen, BT, van Rootselaar, AF, Regidor, I, Duker, AP, Ondo, W, Guridi, J, Volkmann, J, Shukla, AW, Mandybur, GT, Okun, MS, Witt, K, Starr, PA, Deuschl, G & Espay, AJ 2017, Movement Disorders. DOI: 10.1002/mds.27082

Clinical and demographic characteristics related to onset site and spread of cervical dystonia
Norris, SA, Jinnah, HA, Espay, AJ, Klein, C, Brüggemann, N, Barbano, RL, Malaty, IAC, Rodriguez, RL, Vidailhet, M, Roze, E, Reich, SG, Berman, BD, LeDoux, MS, Richardson, SP, Agarwal, P, Mari, Z, Ondo, WG, Shih, LC, Fox, SH, Berardelli, A, Testa, CM, Cheng, FCF, Truong, D, Nahab, FB, Xie, T, Hallett, M, Rosen, AR, Wright, LJ & Perlmutter, JS 2016, Movement Disorders, vol 31, no. 12, pp. 1874-1882. DOI: 10.1002/mds.26817

Knowledge gaps and research recommendations for essential tremor
Hopfner, F, Haubenberger, D, Galpern, WR, Gwinn, K, Vant Veer, A, White, S, Bhatia, K, Adler, CH, Eidelberg, D, Ondo, W, Stebbins, GT, Tanner, CM, Helmich, RC, Lenz, FA, Sillitoe, RV, Vaillancourt, D, Vitek, JL, Louis, ED, Shill, HA, Frosch, MP, Foroud, T, Kuhlenbäumer, G, Singleton, A, Testa, CM, Hallett, M, Elble, R & Deuschl, G 2016, Parkinsonism and Related Disorders, vol 33, pp. 27-35. DOI: 10.1016/j.parkreldis.2016.10.002

Practice guideline summary: Treatment of restless legs syndrome in adults: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology
Winkelman, JW, Armstrong, MJ, Allen, RP, Chaudhuri, KR, Ondo, W, Trenkwalder, C, Zee, PC, Gronseth, GS, Gloss, D & Zesiewicz, T 2016, Neurology. DOI: 10.1212/WNL.0000000000003388

A randomized trial of focused ultrasound thalamotomy for essential tremor
Elias, WJ, Lipsman, N, Ondo, WG, Ghanouni, P, Kim, YG, Lee, W, Schwartz, M, Hynynen, K, Lozano, AM, Shah, BB, Huss, D, Dallapiazza, RF, Gwinn, R, Witt, J, Ro, S, Eisenberg, HM, Fishman, PS, Gandhi, D, Halpern, CH, Chuang, R, Pauly, KB, Tierney, TS, Hayes, MT, Cosgrove, GR, Yamaguchi, T, Abe, K, Taira, T & Chang, JW 2016, New England Journal of Medicine, vol 375, no. 8, pp. 730-739. DOI: 10.1056/NEJMoa1600159

Guidelines for the first-line treatment of restless legs syndrome/Willis-Ekbom disease, prevention and treatment of dopaminergic augmentation: A combined task force of the IRLSSG, EURLSSG, and the RLS-foundation
Garcia-Borreguero, D, Silber, MH, Winkelman, JW, Högl, B, Bainbridge, J, Buchfuhrer, M, Hadjigeorgiou, G, Inoue, Y, Manconi, M, Oertel, W, Ondo, W, Winkelmann, J & Allen, RP 2016, Sleep Medicine, vol 21, pp. 1-11. DOI: 10.1016/j.sleep.2016.01.017

OnabotulinumtoxinA and AbobotulinumtoxinA Dose Conversion: a Systematic Literature Review
Dashtipour, K, Chen, JJ, Espay, AJ, Mari, Z & Ondo, W 2016, Movement Disorders Clinical Practice, vol 3, no. 2, pp. 109-115. DOI: 10.1002/mdc3.12235

Essential Tremor: What We Can Learn from Current Pharmacotherapy
Ondo, W 2016, Tremor and Other Hyperkinetic Movements, vol 2016, pp. 356. DOI: 10.7916/D8K35TC3

Essential tremor: What we can learn from current pharmacotherapy
Ondo, W 2016, Tremor and Other Hyperkinetic Movements, vol 2016. DOI: 10.7916/D8K35TC3

Efficacy of gabapentin enacarbil in adult patients with severe primary restless legs syndrome
Lee, DO, Buchfuhrer, MJ, Garcia-Borreguero, D, Avidan, AY, Ahmed, M, Hays, R, Ondo, WG, Jaros, MJ, Kim, R & Shang, G 2016, Sleep Medicine, vol 19, pp. 50-56. DOI: 10.1016/j.sleep.2015.11.002

Depth and distribution of symptoms in restless legs syndrome/ Willis-Ekbom disease
Yeh, P, Ondo, WG, Picchietti, DL, Steven Poceta, J, Allen, RP, Davies, CR, Wang, L, Shi, Y, Bagai, K & Walters, AS 2016, Journal of Clinical Sleep Medicine, vol 12, no. 12, pp. 1669-1680. DOI: 10.5664/jcsm.6356

Post hoc analysis of data from two clinical trials evaluating the minimal clinically important change in international restless legs syndrome sum score in patients with restless legs syndrome (willis-ekbom disease)
Ondo, WG, Grieger, F, Moran, K, Kohnen, R & Roth, T 2016, Journal of Clinical Sleep Medicine, vol 12, no. 1, pp. 63-70. DOI: 10.5664/jcsm.5396

Deep brain stimulation (DBS) for severe restless legs syndrome: Therapeutic and physiologic considerations
Ondo, W 2016, Sleep Medicine. DOI: 10.1016/j.sleep.2016.04.005

A novel scale to assess psychosis in patients with parkinson's disease
Ondo, WG, Sarfaraz, S & Lee, M 2015, Journal of clinical movement disorders, vol 2, pp. 17. DOI: 10.1186/s40734-015-0024-5

Effect of prior exposure to dopamine agonists on treatment with gabapentin enacarbil in adults with moderate-to-severe primary restless legs syndrome: pooled analyses from 3 randomized trials
Ondo, WG, Hermanowicz, N, Borreguero, DG, Jaros, MJ, Kim, R & Shang, G 2015, Journal of clinical movement disorders, vol 2, pp. 9. DOI: 10.1186/s40734-015-0018-3

Does idiopathic restless legs syndrome delay onset and reduce severity of Parkinson's disease: A pilot study
Dragan, EM, Chen, Z & Ondo, WG 2015, International Journal of Neuroscience, vol 125, no. 7, pp. 526-530. DOI: 10.3109/00207454.2014.987771

Deep brain stimulation in other neurological and psychiatric conditions
Ondo, W 2015, . in Deep Brain Stimulation. Nova Science Publishers, Inc. pp. 195-212.