Not found

Wenhao Chen, PhD

Assistant Professor of Transplant Immunology in Surgery, Institute for Academic Medicine
Assistant Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Biography

Dr. Wenhao Chen earned his Ph.D. in Biomedical Science from the University of Toronto in 2006. He held faculty appointments at the University of Toledo College of Medicine in Toledo, Ohio and Baylor College of Medicine in Houston, Texas before becoming a member of Houston Methodist Research Institute in 2013. As a member of the Transplantation Immunology Program, Dr. Chen studies the cellular and molecular mechanisms underlying immune tolerance. He has published more than 40 original papers and review articles in high-impact scientific journals.

Description of Research

Dr. Chen’s research interests are to define the molecular mechanisms by which immune cells reject the transplanted organs or cause autoimmune type 1 diabetes and develop novel strategies to selectively abrogate undesired immune responses against self-islets or transplanted organs.

Areas Of Expertise

Transplantation Type 1 diabetes T cell Immune tolerance
Education & Training

Postdoctoral Associate , Baylor College of Medicine
Postdoctoral Fellowship , University of Texas Medical School at Houston
Postdoctoral Fellowship , University of Toronto
PhD , University of Toronto
Publications

Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4+ T Cell Dysfunction
Wu, J, Zhang, H, Shi, X, Xiao, X, Fan, Y, Minze, LJ, Wang, J, Ghobrial, RM, Xia, J, Sciammas, R, Li, XC & Chen, W 2017, Immunity. DOI: 10.1016/j.immuni.2017.11.003

Macrophage subpopulations and their impact on chronic allograft rejection versus graft acceptance in a mouse heart transplant model
Zhao, Y, Chen, S, Lan, P, Wu, C, Dou, Y, Xiao, X, Zhang, Z, Minze, L, He, X, Chen, W & Li, XC 2017, American Journal of Transplantation. DOI: 10.1111/ajt.14543

Anti-Tcrbmabin combination with neurogenin3gene therapy reverses established overt type 1 diabetes in female nod mice
Xie, A, Li, R, Jiang, T, Yan, H, Zhang, H, Yang, Y, Yang, L, Yechoor, V, Chan, L & Chen, W 2017, Endocrinology, vol 158, no. 10, pp. 3140-3151. DOI: 10.1210/en.2016-1947

Dissonant response of M0/M2 and M1 bone-marrow-derived macrophages to RhoA pathway interference
Liu, Y, Chen, W, Minze, LJ, Kubiak, JZ, Li, XC, Ghobrial, RM & Kloc, M 2016, Cell and Tissue Research, pp. 1-14. DOI: 10.1007/s00441-016-2491-x

Macrophage/monocyte-specific deletion of Ras homolog gene family member A (RhoA) downregulates fractalkine receptor and inhibits chronic rejection of mouse cardiac allografts
Liu, Y, Chen, W, Wu, C, Minze, LJ, Kubiak, JZ, Li, XC, Kloc, M & Ghobrial, RM 2016, Journal of Heart and Lung Transplantation. DOI: 10.1016/j.healun.2016.08.011

Proinsulin-producing, hyperglycemia-induced adipose tissue macrophages underlie insulin resistance in high fat-fed diabetic mice
Dale Buras, E, Yang, L, Saha, P, Kim, J, Mehta, P, Yang, Y, Hilsenbeck, S, Kojima, H, Chen, W, Smith, CW & Chan, L 2015, FASEB Journal, vol 29, no. 8, pp. 3537-3548. DOI: 10.1096/fj.15-271452

PD-1-dependent restoration of self-tolerance in the NOD mouse model of diabetes after transient anti-TCRß mAb therapy
Schroder, PM, Khattar, M, Baum, CE, Miyahara, Y, Chen, W, Vyas, R, Muralidharan, S, Mierzejewska, B & Stepkowski, SM 2015, Diabetologia, vol 58, no. 6, pp. 1309-1318. DOI: 10.1007/s00125-015-3564-1

PD-L1-driven tolerance protects neurogenin3-induced islet neogenesis to reverse established type 1 diabetes in NOD mice
Li, R, Lee, J, Kim, MS, Liu, V, Moulik, M, Li, H, Yi, Q, Xie, A, Chen, W, Yang, L, Li, Y, Tsai, TH, Oka, K, Chan, L & Yechoor, V 2015, Diabetes, vol 64, no. 2, pp. 529-540. DOI: 10.2337/db13-1737

TCR stimulation without co-stimulatory signals induces expression of "tolerogenic" genes in memory CD4 T cells but does not compromise cell proliferation
Xie, A, Zheng, X, Khattar, M, Schroder, P, Stepkowski, S, Xia, J & Chen, W 2015, Molecular Immunology, vol 63, no. 2, pp. 406-411. DOI: 10.1016/j.molimm.2014.09.013

The evolving roles of memory immune cells in transplantation
Chen, W , Ghobrial, RM & Li, XC 2015, Transplantation, vol 99, no. 10, pp. 2029-2037. DOI: 10.1097/TP.0000000000000802

Type 1 Diabetes Mellitus: Immune Modulation as a Prerequisite for Successful Gene Therapy Strategies
Chen, W, Xie, A, Wu, J & Chan, L 2014, . in Translating Gene Therapy to the Clinic: Techniques and Approaches. Elsevier, pp. 99-113. DOI: 10.1016/B978-0-12-800563-7.00007-5

Anti-TCR mAb induces peripheral tolerance to alloantigens and delays islet allograft rejection in autoimmune diabetic NOD mice
Deng, R, Khattar, M, Xie, A, Schroder, PM, He, X, Chen, W & Stepkowski, SM 2014, Transplantation, vol 97, no. 12, pp. 1216-1224. DOI: 10.1097/TP.0000000000000120

Interleukin-21 is a critical regulator of CD4 and CD8 T cell survival during priming under interleukin-2 deprivation conditions
Khattar, M, Miyahara, Y, Schroder, PM, Xie, A, Chen, W & Stepkowski, SM 2014, PLoS ONE, vol 9, no. 1, e85882. DOI: 10.1371/journal.pone.0085882

Molecular insights into the development of T cell-based immunotherapy for prostate cancer
Dong, B, Minze, LJ, Xue, W & Chen, W 2014, Expert Review of Clinical Immunology, vol 10, no. 11, pp. 1547-1557. DOI: 10.1586/1744666X.2014.962515

MAFbx/Atrogin-1 is required for atrophic remodeling of the unloaded heart
Baskin, KK, Rodriguez, MR, Kansara, S, Chen, W, Carranza, S, Frazier, OH, Glass, DJ & Taegtmeyer, H 2014, Journal of Molecular and Cellular Cardiology, vol 72, pp. 168-176. DOI: 10.1016/j.yjmcc.2014.03.006

Pancreatic islet transplantation in mice
Deng, R, Schroder, P & Chen, W 2013, . in Experimental Organ Transplantation. Nova Science Publishers, Inc. pp. 81-98.

T cell and B cell responses in transplantation
Schroder, P, Deng, R & Chen, W 2013, . in Experimental Organ Transplantation. Nova Science Publishers, Inc. pp. 327-343.

Transient Combination Therapy Targeting the Immune Synapse Abrogates T Cell Responses and Prolongs Allograft Survival in Mice
Schroder, PM, Khattar, M, Deng, R, Xie, A, Chen, W & Stepkowski, SM 2013, PLoS ONE, vol 8, no. 7, e69397. DOI: 10.1371/journal.pone.0069397

GM-CSF contributes to aortic aneurysms resulting from SMAD3 deficiency
Ye, P, Chen, W, Wu, J, Huang, X, Li, J, Wang, S, Liu, Z, Wang, G, Yang, X, Zhang, P, Lv, Q & Xia, J 2013, Journal of Clinical Investigation, vol 123, no. 5, pp. 2317-2331. DOI: 10.1172/JCI67356

Mechanistic basis of immunotherapies for type 1 diabetes mellitus
Chen, W, Xie, A & Chan, L 2013, Translational Research, vol 161, no. 4, pp. 217-229. DOI: 10.1016/j.trsl.2012.12.017