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Weiming Xia, PhD

Associate Affiliate Member, Research Institute
Houston Methodist


Genomics of Alzheimer disease: A review
Rosenberg, RN, Lambracht-Washington, D, Yu, G & Xia, W 2016, JAMA Neurology, vol 73, no. 7, pp. 867-874. DOI:

Potential of tocotrienols in the prevention and therapy of Alzheimer's disease
Xia, W & Mo, H 2016, Journal of Nutritional Biochemistry, vol 31, pp. 1-9. DOI:

Peripheral blood mononuclear cell-converted induced pluripotent stem cells (iPSCs) from an early onset Alzheimer's patient
Lee, HK, Morin, P & Xia, W 2016, Stem Cell Research, vol 16, no. 2, pp. 213-215. DOI:

Induced pluripotent stem cells (iPSCs) derived from frontotemporal dementia patient's peripheral blood mononuclear cells
Lee, HK, Morin, P, Wells, J, Hanlon, EB & Xia, W 2015, Stem Cell Research, vol 15, no. 2, pp. 325-327. DOI:

Molecular dynamics simulation study reveals potential substrate entry path into ?-secretase/presenilin-1
Kong, R, Chang, S, Xia, W & Wong, STC 2015, Journal of Structural Biology, vol 191, no. 2, pp. 120-129. DOI:

Beta-amyloid deposition in chronic traumatic encephalopathy
Stein, TD, Montenigro, PH, Alvarez, VE, Xia, W, Crary, JF, Tripodis, Y, Daneshvar, DH, Mez, J, Solomon, T, Meng, G, Kubilus, CA, Cormier, KA, Meng, S, Babcock, K, Kiernan, P, Murphy, L, Nowinski, CJ, Martin, B, Dixon, D, Stern, RA, Cantu, RC, Kowall, NW & McKee, AC 2015, Acta Neuropathologica, vol 130, no. 1, pp. 21-34. DOI:

Chronic treatment with anesthetic propofol attenuates ß-amyloid protein levels in brain tissues of aged mice
Zhang, Y, Shao, H, Dong, Y, Swain, CA, Yu, B, Xia, W & Xie, Z 2014, Translational Neurodegeneration, vol 3, no. 1, 8. DOI:

A new iterative triclass thresholding technique in image segmentation
Cai, H, Yang, Z, Cao, X, Xia, W & Xu, X 2014, IEEE Transactions on Image Processing, vol 23, no. 3, 6705677, pp. 1038-1046. DOI:

Computational techniques in zebrafish image processing and analysis
Xia, S, Zhu, Y, Xu, X & Xia, W 2013, Journal of Neuroscience Methods, vol 213, no. 1, pp. 6-13. DOI:

Modulation of gamma-secretase for the treatment of alzheimer's disease
Tate, B, McKee, TD, Loureiro, RMB, Dumin, JA, Xia, W, Pojasek, K, Austin, WF, Fuller, NO, Hubbs, JL, Shen, R, Jonker, J, Ives, J & Bronk, BS 2012, International Journal of Alzheimers Disease. DOI:

Optimization of a natural product-based class of gamma;-secretase modulators
Hubbs, JL, Fuller, NO, Austin, WF, Shen, R, Creaser, SP, McKee, TD, Loureiro, RMB, Tate, B, Xia, W, Ives, J & Bronk, BS 2012, Journal of Medicinal Chemistry, vol 55, no. 21, pp. 9270-9282. DOI:

Initial optimization of a new series of ?-secretase modulators derived from a triterpene glycoside
Fuller, NO, Hubbs, JL, Austin, WF, Creaser, SP, McKee, TD, Loureiro, RMB, Tate, B, Xia, W, Ives, JL, Findeis, MA & Bronk, BS 2012, ACS Medicinal Chemistry Letters, vol 3, no. 11, pp. 908-913. DOI:

?-Secretase modulator in Alzheimer's Disease: Shifting the end
Xia, W , Wong, ST, Hanlon, E & Morin, P 2012, Journal of Alzheimers Disease, vol 31, no. 4, pp. 685-696. DOI:

Prenatal lead levels, plasma amyloid ß levels, and gene expression in young adulthood
Mazumdar, M, Xia, W, Hofmann, O, Gregas, M, Sui, SH, Hide, W, Yang, T, Needleman, HL & Bellinger, DC 2012, Environmental Health Perspectives, vol 120, no. 5, pp. 702-707.

RNAi-mediated knock-down of Dab and Numb attenuate Aß levels via ?-secretase mediated APP processing
Xie, Z, Dong, Y, Maeda, U, Xia, W & Tanzi, RE 2012, Translational Neurodegeneration, vol 1, 8. DOI:

Immunotherapy of cerebrovascular amyloidosis in a transgenic mouse model
Lifshitz, V, Weiss, R, Benromano, T, Kfir, E, Blumenfeld-Katzir, T, Tempel-Brami, C, Assaf, Y, Xia, W, Wyss-Coray, T, Weiner, HL & Frenkel, D 2012, Neurobiology of Aging, vol 33, no. 2. DOI:

Relation between insulin, insulin-related factors, and plasma amyloid beta peptide levels at midlife in a population-based study
Townsend, MK, Okereke, OI, Xia, W, Yang, T, Selkoe, DJ & Grodstein, F 2012, Alzheimer Disease and Associated Disorders, vol 26, no. 1, pp. 50-54. DOI:

Automated analysis of zebrafish images for phenotypic changes in drug discovery
Chen, S, Zhu, Y, Xia, W, Xia, S & Xu, X 2011, Journal of Neuroscience Methods, vol 200, no. 2, pp. 229-236. DOI:

Detecting and analyzing differentially activated pathways in brain regions of Alzheimer's disease patients
Liu, ZP, Wang, Y, Zhang, XS, Xia, W & Chen, L 2011, Molecular BioSystems, vol 7, no. 5, pp. 1441-1452. DOI:

Alzheimer's disease-linked presenilin mutation (PS1M146L) induces filamin expression and ?-secretase independent redistribution
Lu, Q, Ding, K, Frosch, MP, Jones, S, Wolfe, M, Xia, W & Lanford, GW 2010, Journal of Alzheimers Disease, vol 22, no. 1, pp. 235-245. DOI: