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Tuo Deng, PhD

Assistant Professor of Bioenergetics, Institute for Academic Medicine
Assistant Member, Research Institute
Houston Methodist
Weill Cornell Medical College

Adipocyte adaptive immunity mediates diet-induced adipose inflammation and insulin resistance by decreasing adipose Treg cells
Deng, T, Liu, J, Deng, Y, Minze, LJ, Xiao, X, Wright, V, Yu, R, Li, XC, Blaszczak, A, Bergin, S, DiSilvestro, D, Judd, R, Bradley, D, Caligiuri, M, Lyon, CJ & Hsueh, WA 2017, Nature Communications, vol 8, 15725. DOI:

Epicardial Fat in the Maintenance of Cardiovascular Health
Wu, Y, Zhang, A, Hamilton, DJ & Deng, T 2017, Houston Methodist DeBakey Cardiovascular Journal, vol 13, no. 1, pp. 20-24. DOI:

A switching sensor of C[sbnd]H bond breakage/formation regulated by mediating copper (II)’s complexation
Zhou, X, Li, G, Yang, P, Zhao, L, Deng, T, Shen, H, Yang, Z, Tian, Z & Chen, Y 2017, Sensors and Actuators, B: Chemical, vol 242, pp. 56-62. DOI:

Calix[3]carbazole: A C3-symmetrical receptor for barium ion
Yang, Z, Tian, Z, Yang, P, Deng, T, Li, G, Zhou, X, Chen, Y, Zhao, L & Shen, H 2017, Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, vol 174, pp. 32-36. DOI:

Obesity, Inflammation, and Cancer
Deng, T, Lyon, CJ, Bergin, S, Caligiuri, MA & Hsueh, WA 2016, Annual Review of Pathology: Mechanisms of Disease, vol 11, pp. 421-449. DOI:

Calix[3]carbazole: One-Step Synthesis and Host-Guest Binding
Yang, P, Jian, Y, Zhou, X, Li, G, Deng, T, Shen, H, Yang, Z & Tian, Z 2016, Journal of Organic Chemistry, vol 81, no. 7, pp. 2974-2980. DOI:

Adenosine triphosphate-selective fluorescent turn-on response of a novel thiazole orange derivative via their cooperative co-assembly
Deng, T, Chen, J, Yu, H, Yang, P, Jian, Y, Li, G, Zhou, X, Shen, H & Gui, J 2015, Sensors and Actuators, B: Chemical, vol 209, pp. 735-743. DOI:

Mechanisms of peroxisome proliferator activated receptor ? regulation by non-steroidal anti-inflammatory drugs
Puhl, AC, Milton, FA, Cvoro, A, Sieglaff, DH, Campos, JCL, Bernardes, A, Filgueira, CS, Lindemann, JL, Deng, T, Neves, FAR, Polikarpov, I & Webb, P 2015, Nuclear receptor signaling, vol 13, pp. e004. DOI:

Synthesis of a novel methylene-bridged biscarbazole derivative and evaluation of its DNA and nucleotide binding properties
Li, G, Zhou, X, Yang, P, Jian, Y, Deng, T, Shen, H & Bao, Y 2014, Tetrahedron Letters, vol 55, no. 51, pp. 7054-7059. DOI:

Transcriptome analysis of human adipocytes implicates the NOD-like receptor pathway in obesity-induced adipose inflammation
Yin, Z , Deng, T , Peterson, LE, Yu, R, Lin, J, Hamilton, DJ, Reardon, PR, Sherman, V, Winnier, GE, Zhan, M, Lyon, CJ, Wong, STC & Hsueh, WA 2014, Molecular and Cellular Endocrinology, vol 394, no. 1-2, pp. 80-87. DOI:

Syntheses, spectral properties of novel carbazole derivatives and evaluations of its Ct-DNA interaction
Jian, Y, Li, G, Yang, P, Deng, T, Zhou, X & Xu, H 2014, Chinese Journal of Organic Chemistry, vol 34, no. 4, pp. 809-816. DOI:

Class II major histocompatibility complex plays an essential role in obesity-induced adipose inflammation
Deng, T, Lyon, CJ, Minze, LJ, Lin, J, Zou, J, Liu, JZ, Ren, Y, Yin, Z, Hamilton, DJ, Reardon, PR, Sherman, V, Wang, HY, Phillips, KJ, Webb, P, Wong, STC, Wang, RF & Hsueh, WA 2013, Cell Metabolism, vol 17, no. 3, pp. 411-422. DOI:

Inflammasomes and obesity
Deng, T, Cui, J, Lyon, CJ, Zhang, N, Wang, HY, Wang, RF & Hsueh, WA 2013, . in Obesity, Inflammation and Cancer. Springer New York, pp. 25-60. DOI:

Myeloid deletion of nuclear factor erythroid 2-related factor 2 increases atherosclerosis and liver injury
Collins, AR, Gupte, AA, Ji, R, Ramirez, MR, Minze, LJ, Liu, JZ, Arredondo, M, Ren, Y, Deng, T, Wang, J, Lyon, CJ & Hsueh, WA 2012, Arteriosclerosis, Thrombosis, and Vascular Biology, vol 32, no. 12, pp. 2839-2846. DOI:

MicroRNA-133b is a key promoter of cervical carcinoma development through the activation of the ERK and AKT1 pathways
Qin, W, Dong, P, Ma, C, Mitchelson, K, Deng, T, Zhang, L, Sun, Y, Feng, X, Ding, Y, Lu, X, He, J, Wen, H & Cheng, J 2012, Oncogene, vol 31, no. 36, pp. 4067-4075. DOI:

Medium chain fatty acids are selective peroxisome proliferator activated receptor (PPAR) ? activators and Pan-PPAR partial agonists
Liberato, MV, Nascimento, AS, Ayers, SD, Lin, JZ, Cvoro, A, Silveira, RL, Martínez, L, Souza, PCT, Saidemberg, D, Deng, T, Amato, AA, Togashi, M, Hsueh, WA, Phillips, K, Palma, MS, Neves, FAR, Skaf, MS, Webb, P & Polikarpov, I 2012, PLoS ONE, vol 7, no. 5, e36297. DOI:

A peroxisome proliferator-activated receptor ? (PPAR?)/ PPAR? coactivator 1ß autoregulatory loop in adipocyte mitochondrial function
Deng, T, Sieglaff, DH, Zhang, A, Lyon, CJ, Ayers, SD, Cvoro, A, Gupte, AA, Xia, X, Baxter, JD, Webb, P & Hsueh, WA 2011, Journal of Biological Chemistry, vol 286, no. 35, pp. 30723-30731. DOI:

Complementary analysis of microRNA and mRNA expression during phorbol 12-myristate 13-acetate (TPA)-induced differentiation of HL-60 cells
Chen, A, Luo, M, Yuan, G, Yu, J, Deng, T, Zhang, L, Zhou, Y, Mitchelson, K & Cheng, J 2008, Biotechnology Letters, vol 30, no. 12, pp. 2045-2052. DOI:

Peroxisome proliferator-activated receptor-? transcriptionally up-regulates hormone-sensitive lipase via the involvement of specificity protein-1
Deng, T, Shan, S, Li, PP, Shen, ZF, Lu, XP, Cheng, J & Ning, ZQ 2006, Endocrinology, vol 147, no. 2, pp. 875-884. DOI:

Phthalide lactones from Ligusticum chuanxiong inhibit lipopolysaccharide- induced TNF-a production and TNF-a-mediated NF-?B activation
Liu, L, Ning, ZQ, Shan, S, Zhang, K, Deng, T, Lu, XP & Cheng, YY 2005, Planta Medica, vol 71, no. 9, pp. 808-813. DOI: