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Tuo Deng, PhD

Assistant Professor of Genomic Medicine, Institute for Academic Medicine
Assistant Member, Research Institute
Houston Methodist
Weill Cornell Medical College

Obesity, Inflammation, and Cancer
Deng, T, Lyon, CJ, Bergin, S, Caligiuri, MA & Hsueh, WA 2016, Annual Review of Pathology: Mechanisms of Disease, vol 11, pp. 421-449. DOI:

Calix[3]carbazole: One-Step Synthesis and Host-Guest Binding
Yang, P, Jian, Y, Zhou, X, Li, G, Deng, T, Shen, H, Yang, Z & Tian, Z 2016, Journal of Organic Chemistry, vol 81, no. 7, pp. 2974-2980. DOI:

Adenosine triphosphate-selective fluorescent turn-on response of a novel thiazole orange derivative via their cooperative co-assembly
Deng, T, Chen, J, Yu, H, Yang, P, Jian, Y, Li, G, Zhou, X, Shen, H & Gui, J 2015, Sensors and Actuators, B: Chemical, vol 209, pp. 735-743. DOI:

Synthesis of a novel methylene-bridged biscarbazole derivative and evaluation of its DNA and nucleotide binding properties
Li, G, Zhou, X, Yang, P, Jian, Y, Deng, T, Shen, H & Bao, Y 2014, Tetrahedron Letters, vol 55, no. 51, pp. 7054-7059. DOI:

Transcriptome analysis of human adipocytes implicates the NOD-like receptor pathway in obesity-induced adipose inflammation
Yin, Z , Deng, T , Peterson, LE, Yu, R, Lin, J, Hamilton, DJ, Reardon, PR, Sherman, V, Winnier, GE, Zhan, M, Lyon, CJ, Wong, STC & Hsueh, WA 2014, Molecular and Cellular Endocrinology, vol 394, no. 1-2, pp. 80-87. DOI:

Syntheses, spectral properties of novel carbazole derivatives and evaluations of its Ct-DNA interaction
Jian, Y, Li, G, Yang, P, Deng, T, Zhou, X & Xu, H 2014, Chinese Journal of Organic Chemistry, vol 34, no. 4, pp. 809-816. DOI:

Class II major histocompatibility complex plays an essential role in obesity-induced adipose inflammation
Deng, T, Lyon, CJ, Minze, LJ, Lin, J, Zou, J, Liu, JZ, Ren, Y, Yin, Z, Hamilton, DJ, Reardon, PR, Sherman, V, Wang, HY, Phillips, KJ, Webb, P, Wong, STC, Wang, RF & Hsueh, WA 2013, Cell Metabolism, vol 17, no. 3, pp. 411-422. DOI:

Myeloid deletion of nuclear factor erythroid 2-related factor 2 increases atherosclerosis and liver injury
Collins, AR, Gupte, AA, Ji, R, Ramirez, MR, Minze, LJ, Liu, JZ, Arredondo, M, Ren, Y, Deng, T, Wang, J, Lyon, CJ & Hsueh, WA 2012, Arteriosclerosis, Thrombosis, and Vascular Biology, vol 32, no. 12, pp. 2839-2846. DOI:

MicroRNA-133b is a key promoter of cervical carcinoma development through the activation of the ERK and AKT1 pathways
Qin, W, Dong, P, Ma, C, Mitchelson, K, Deng, T, Zhang, L, Sun, Y, Feng, X, Ding, Y, Lu, X, He, J, Wen, H & Cheng, J 2012, Oncogene, vol 31, no. 36, pp. 4067-4075. DOI:

Medium chain fatty acids are selective peroxisome proliferator activated receptor (PPAR) ? activators and Pan-PPAR partial agonists
Liberato, MV, Nascimento, AS, Ayers, SD, Lin, JZ, Cvoro, A, Silveira, RL, Martínez, L, Souza, PCT, Saidemberg, D, Deng, T, Amato, AA, Togashi, M, Hsueh, WA, Phillips, K, Palma, MS, Neves, FAR, Skaf, MS, Webb, P & Polikarpov, I 2012, PLoS ONE, vol 7, no. 5, e36297. DOI:

A peroxisome proliferator-activated receptor ? (PPAR?)/ PPAR? coactivator 1ß autoregulatory loop in adipocyte mitochondrial function
Deng, T, Sieglaff, DH, Zhang, A, Lyon, CJ, Ayers, SD, Cvoro, A, Gupte, AA, Xia, X, Baxter, JD, Webb, P & Hsueh, WA 2011, Journal of Biological Chemistry, vol 286, no. 35, pp. 30723-30731. DOI:

Complementary analysis of microRNA and mRNA expression during phorbol 12-myristate 13-acetate (TPA)-induced differentiation of HL-60 cells
Chen, A, Luo, M, Yuan, G, Yu, J, Deng, T, Zhang, L, Zhou, Y, Mitchelson, K & Cheng, J 2008, Biotechnology Letters, vol 30, no. 12, pp. 2045-2052. DOI:

Peroxisome proliferator-activated receptor-? transcriptionally up-regulates hormone-sensitive lipase via the involvement of specificity protein-1
Deng, T, Shan, S, Li, PP, Shen, ZF, Lu, XP, Cheng, J & Ning, ZQ 2006, Endocrinology, vol 147, no. 2, pp. 875-884. DOI:

Phthalide lactones from Ligusticum chuanxiong inhibit lipopolysaccharide- induced TNF-a production and TNF-a-mediated NF-?B activation
Liu, L, Ning, ZQ, Shan, S, Zhang, K, Deng, T, Lu, XP & Cheng, YY 2005, Planta Medica, vol 71, no. 9, pp. 808-813. DOI:

A new retinoid-like compound that activates peroxisome proliferator- activated receptors and lowers blood glucose in diabetic mice
Deng, T, Shan, S, Li, ZB, Wu, ZW, Liao, CZ, Ko, B, Lu, XP, Cheng, J & Ning, ZQ 2005, Biological and Pharmaceutical Bulletin, vol 28, no. 7, pp. 1192-1196. DOI: