Timothy B. Boone, MD, PhD

Chair, Department of Urology
Co-Director, Professor of Urology, Institute for Academic Medicine
Full Member, Research Institute
Program Director, Continence, Pelvic Reconstructive Surgery, & Neurourology Residency, Department of Urology
Director, Regenerative Medicine Program
Houston Methodist
Weill Cornell Medical College


Dr. Timothy B. Boone is the Chair of the Urology Department, Co-Director of the Institute for Academic Medicine and a member of the Neurological Institute at Houston Methodist Hospital. He is Professor of Urology at Weill Cornell Medical College and holds appointments as Professor of Urology at Texas A&M College of Medicine and Baylor College of Medicine where he is a Clinical Professor of Urology. In 2014, Dr. Boone was appointed Vice Dean, Texas A&M University College of Medicine at the Houston campus.
Dr. Boone earned his Master of Science in physiology and Ph.D. in neuroscience at the University of Texas Graduate School of Biomedical Sciences at Houston. He completed his M.D./Ph.D. at the University of Texas Medical School at Houston and urology residency training at the University of Texas Southwestern Medical School in Dallas. In 1991 he joined the faculty in the Department of Urology at UT Southwestern for two years and then moved to Baylor College of Medicine where he joined the Scott Department of Urology. In 2000 Dr. Boone was named Professor and Chair of the Scott Department of Urology where he served until 2008. For over 20 years he has actively participated in the care of spinal cord injured veterans with neurogenic bladder dysfunction at the VA Spinal Cord Injury Unit in Dallas and in Houston.
Boone specializes in the treatment of patients with incontinence following prostatectomy, women with complex voiding disorders, and bladder problems related to neurologic disease including spinal cord injury, stroke, multiple sclerosis, and Parkinson's disease. He maintains active participation in research, focusing on mechanisms of sensory control and dysfunction in the bladder and urethra that are related to spinal cord injury, diabetes or obstruction. Dr. Boone is the Primary Investigator for the Neuroregeneration and Bladder Sensory Science Laboratory at the Houston Methodist Research Institute.
Throughout his career Dr. Boone has written over 100 publications and given hundreds of lectures regionally and nationally while serving as a visiting professor for many departments of urology. He is a member of the American Association of Genitourinary Surgeons, Clinical Society of GU Surgeons, American Urological Association, Texas Urological Society, Society for Neuroscience, Society for Urodynamics, Female Pelvic Medicine and Urogenital Reconstruction, and the AOA Honor Medical Society. He serves as consultant reviewer for several scientific journals including Neurourology and Urodynamics, Journal of Urology, British Journal of Urology, Urology, Spinal Cord, and the New England Journal of Medicine. He is on the editorial board of Nature Reviews in Urology. Dr. Boone was elected as a Trustee to the American Board of Urology in 2006 and served as President of the American Board of Urology from 2011 - 2012.

Description of Research

Incontinence, Neurourology, Neurogenic Bladder, Urinary Diversion and Urinary Reconstruction

Areas Of Expertise

Incontinence Neurourology Neurogenic Bladder Regenerative Medicine Urinary Diversion and Urinary Reconstruction
Education & Training

Residency, UT Southwestern Medical Center
Internship, The University of Texas Health Science Center at Houston
PhD, University of Texas Graduate School of Biomedical Science - Houston
MD, University of Texas at Houston Medical School

Electrical activity of the bladder is attenuated by intravesical inhibition of P2X2/3 receptors during micturition in female rats
Salazar, BH, Hoffman, KA, Zhang, C, Kavanagh, A, Zhang, Y, Boone, TB & Munoz, A 2017, International Neurourology Journal, vol 21, no. 4, pp. 259-269. DOI: 10.5213/inj.1734998.499

Workflow for Visualization of Neuroimaging Data with an Augmented Reality Device
Karmonik, C , Boone, TB & Khavari, R 2017, Journal of Digital Imaging, pp. 1-6. DOI: 10.1007/s10278-017-9991-4

Localized inhibition of P2X7R at the spinal cord injury site improves neurogenic bladder dysfunction by decreasing urothelial P2X3R expression in rats
Munoz, A, Yazdi, IK, Tang, X, Rivera, C, Taghipour, N, Grossman, RG, Boone, TB & Tasciotti, E 2017, Life Sciences, vol 171, pp. 60-67. DOI: 10.1016/j.lfs.2016.12.017

Protocol for a prospective observational study of cortical lower urinary tract control changes following intradetrusor injection of botulinum toxin-A in patients with multiple sclerosis
Elizondo, RA, Karmonik, C, Boone, TB & Khavari, R 2017, BMJ Open, vol 7, no. 2, e013225. DOI: 10.1136/bmjopen-2016-013225

Functional Magnetic Resonance Imaging with Concurrent Urodynamic Testing Identifies Brain Structures Involved in Micturition Cycle in Patients with Multiple Sclerosis
Khavari, R , Karmonik, C, Shy, M, Fletcher, S & Boone, T 2017, The Journal of Urology, vol 197, no. 2, pp. 438-444. DOI: 10.1016/j.juro.2016.09.077

Pelvic floor dynamics during high-impact athletic activities: A computational modeling study
Dias, N, Peng, Y, Khavari, R, Nakib, NA, Sweet, RM, Timm, GW, Erdman, AG, Boone, TB & Zhang, Y 2017, Clinical Biomechanics, vol 41, pp. 20-27. DOI: 10.1016/j.clinbiomech.2016.11.003

Functional mapping of the pelvic floor and sphincter muscles from high-density surface EMG recordings
Peng, Y, He, J, Khavari, R, Boone, TB & Zhang, Y 2016, International Urogynecology Journal and Pelvic Floor Dysfunction, pp. 1-8. DOI: 10.1007/s00192-016-3026-4

Antibody-mediated inhibition of Nogo-A signaling promotes neurite growth in PC-12 cells
Yazdi, IK, Taghipour, N, Hmaidan, S, Palomba, R, Scaria, S, Munoz, A, Boone, TB & Tasciotti, E 2016, Journal of Tissue Engineering, vol 7, pp. 1-9. DOI: 10.1177/2041731416629767

Bladder dysfunction in 2015: Novel findings continue to challenge researchers and clinicians
Khavari, R & Boone, T 2016, Nature Reviews Urology, vol 13, no. 2, pp. 69-70. DOI: 10.1038/nrurol.2015.303

Reduction cystoplasty
Kavanagh, A, Stewart, J & Boone, T 2016, . in CR Chapple, A Wein & NI Osman (eds), Underactive Bladder. Springer International Publishing, pp. 63-67. DOI: 10.1007/978-3-319-43087-4_9

How to Decide Whether an Artificial Urinary Sphincter or a Male Sling is Best for Male Stress Urinary Incontinence
Boone, TB 2016, Journal of Urology, vol 196, no. 3, pp. 641-2. DOI: 10.1016/j.juro.2016.06.077

Pelvic organ prolapse in female patients presenting to transitional urology care clinic
Khavari, R, Tokaz, MC, Stewart, JN & Boone, TB 2015, Journal of Urology, vol 194, no. 6, pp. 1654-1658. DOI: 10.1016/j.juro.2015.07.086

Solifenacin and Tamsulosin Combination Therapy Decreases Urine Nerve Growth Factor/Creatinine Levels in Men
Chan, R, Munoz, A, Wenker, EP, Whipple, M, Miles, B & Boone, TB 2015, Urology. DOI: 10.1016/j.urology.2016.01.020

The single-incision sling to treat female stress urinary incontinence: A dynamic computational study of outcomes and risk factors
Peng, Y, Khavari, R, Nakib, NA, Stewart, JN, Boone, TB & Zhang, Y 2015, Journal of Biomechanical Engineering, vol 137, no. 9, 91007. DOI: 10.1115/1.4030978

Inhibition of urothelial P2X3 receptors prevents desensitization of purinergic detrusor contractions in the rat bladder
Ferguson, AC, Sutton, BW, Boone, TB, Ford, AP & Munoz, A 2015, BJU International, vol 116, no. 2, pp. 293-301. DOI: 10.1111/bju.13003

Imaging: CNS changes in interstitial cystitis/painful bladder syndrome
Khavari, R & Boone, T 2015, Nature Reviews Urology, vol 12, no. 7, pp. 365-366. DOI: 10.1038/nrurol.2015.142

Revision Techniques after Artificial Urinary Sphincter Failure in Men: Results from a Multicenter Study
Eswara, JR, Chan, R, Vetter, JM, Lai, HH, Boone, TB & Brandes, SB 2015, Urology, vol 86, no. 1, pp. 176-180. DOI: 10.1016/j.urology.2015.04.023

Functional brain interactions during reflexive micturition are absent from spinal cord injured rats with neurogenic bladder
Wong, K , Boone, TB , Wong, STC & Munoz, A 2015, Neurourology and Urodynamics, vol 34, no. 5, pp. 469-474. DOI: 10.1002/nau.22596

The association of urinary nerve growth factor levels with bladder outlet obstruction in women
Chan, R, Munoz, A, Wenker, EP, Stewart, J, Boone, T & Khavari, R 2015, Female Pelvic Medicine and Reconstructive Surgery, vol 21, no. 2, pp. 111-115. DOI: 10.1097/SPV.0000000000000126

The fate of transitional urology patients referred to a tertiary transitional care center
Chan, R, Scovell, J, Jeng, Z, Rajanahally, S, Boone, T & Khavari, R 2014, Urology, vol 84, no. 6, pp. 1544-1548. DOI: 10.1016/j.urology.2014.08.022