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Tej Pandita, PhD

Professor of Radiation Oncology, Institute for Academic Medicine
Full Member, Research Institute
Scientific Director, Department of Radiation Oncology
Houston Methodist
Weill Cornell Medical College


Dr. Pandita earned his Ph.D. in Cytogenetics from Panjab University in 1980. He held faculty appointments at Columbia University in New York, Washington University in St.  Louis, Missouri, and The University of Texas Southwestern Medical Center in Dallas, Texas before becoming a member of the Houston Methodist Research Institute in 2014.  As a member of the Cancer Research Program, he directs a research program focusing on DNA repair and radiotherapy.  Dr. Pandita was elected the Fellow of the American Association of Advancement of Science in 2013. He has also been a member of several NIH study sections and review boards. He is the past Chairman of A-T Workshop 2012 (ATW2012) International meeting. Dr. Pandita serves on the editorial board for the journals Cancer Research, Genomic Integrity, BMC Genomics, and served as a chartered member of the CMAD NIH Study Section.

Description of Research

Dr. Pandita's research employs radiation genetics and biology to study the relationships between DNA sequence, chromatin structure and sensitivity to IR. The long-term goal of the research projects is to understand the mechanistic role of chromatin structure in regulating the cell survival response to IR-induced DNA damage. This knowledge base will be used by the laboratory to develop clinically relevant methods to increase tumor cell response to IR-based therapies while decreasing injury to adjacent, normal tissue.

Dr. Pandita's main areas of research are the following:
-To define, at the chromatin level, the function of H4K16ac in DNA DSB repair.
-To determine the role of ATM dependent MOF phosphorylation in the cellular response to IR.
-To determine the pathobiology of mutant mice defective for MOF T392 phosphorylation in order to test the hypothesis that Mof plays a critical role in oncogenic transformation in vivo.
-To determine the mechanisitic basis for enhanced tumor cell radiosensitivity following HP1ß loss or hyperthermia.

Areas Of Expertise

DNA damage response DNA DSB repair Radiation Signaling Telomere metabolism Chromatin structure
Education & Training

, Kashmir University, Srinagar
, National Botanical Research Institute, Council of Scientific and Industrial Research, Lucknow
, Punjab University, Chandigarh

HOXC10 expression supports the development of chemotherapy resistance by fine tuning DNA repair in breast cancer cells
Sadik, H, Korangath, P, Nguyen, NK, Gyorffy, B, Kumar, R, Hedayati, M, Teo, WW, Park, S, Panday, H, Munoz, TG, Menyhart, O, Shah, N, Pandita, RK, Chang, JC, DeWeese, T, Chang, HY, Pandita, TK & Sukumar, S 2016, Cancer Research, vol 76, no. 15, pp. 4443-4456. DOI:

Pluripotent stem cells and DNA damage response to ionizing radiations
Mujoo, K , Butler, EB, Pandita, RK, Hunt, CR & Pandita, TK 2016, Radiation Research, vol 186, no. 1, pp. 17-26. DOI:

ß2-spectrin depletion impairs DNA damage repair
Horikoshi, N, Pandita, RK, Mujoo, K, Hambarde, S, Sharma, D, Mattoo, AR, Chakraborty, S, Charaka, V, Hunt, CR & Pandita, TK 2016, Oncotarget, vol 7, no. 23, pp. 33557-33570. DOI:

The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation
Jacquet, K, Fradet-Turcotte, A, Avvakumov, N, Lambert, JP, Roques, C, Pandita, RK, Paquet, E, Herst, P, Gingras, AC, Pandita, TK, Legube, G, Doyon, Y, Durocher, D & Côté, J 2016, Molecular Cell, vol 62, no. 3, pp. 409-421. DOI:

Torin2 suppresses ionizing radiation-induced DNA damage repair
Udayakumar, D, Pandita, RK, Horikoshi, N, Liu, Y, Liu, Q, Wong, KK, Hunt, CR, Gray, NS, Minna, JD, Pandita, TK & Westover, KD 2016, Radiation Research, vol 185, no. 5, pp. 527-538. DOI:

Emerging therapeutic targets in esophageal adenocarcinoma
Gaur, P, Hunt, CR & Pandita, TK 2016, Oncotarget. DOI:

The many faces of histone H3K79 methylation
Farooq, Z, Banday, S, Pandita, TK & Altaf, M 2016, Mutation Research - Reviews in Mutation Research, vol 768, pp. 46-52. DOI:

A multifaceted role for MOF histone modifying factor in genome maintenance
Mujoo, K, Hunt, CR, Horikoshi, N & Pandita, TK 2016, Mechanisms of Ageing and Development. DOI:

Neil2-null mice accumulate oxidized DNA bases in the transcriptionally active sequences of the genome and are susceptible to innate inflammation
Chakraborty, A, Wakamiya, M, Venkova-Canova, T, Pandita, RK, Aguilera-Aguirre, L, Sarker, AH, Singh, DK, Hosoki, K, Wood, TG, Sharma, G, Cardenas, V, Sarkar, PS, Sur, S, Pandita, TK, Boldogh, I & Hazra, TK 2015, Journal of Biological Chemistry, vol 290, no. 41, pp. 24636-24648. DOI:

More complex transcriptional regulation and stress response by MOF
Horikoshi, N, Hunt, CR & Pandita, TK 2015, Oncogene. DOI:

ATM functions at the peroxisome to induce pexophagy in response to ROS
Zhang, J, Tripathi, DN, Jing, J, Alexander, A, Kim, J, Powell, RT, Dere, R, Tait-Mulder, J, Lee, JH, Paull, TT, Pandita, RK, Charaka, VK, Pandita, TK, Kastan, MB & Walker, CL 2015, Nature Cell Biology, vol 17, no. 10, pp. 1259-1269. DOI:

Detecting ATM-dependent chromatin modification in DNA damage response
Udayakumar, D, Horikoshi, N, Mishra, L, Hunt, C & Pandita, TK 2015, . in Chromatin Protocols: Third Edition. Springer New York, pp. 317-336. DOI:

BRUCE regulates DNA double-strand break response by promoting USP8 deubiquitination of BRIT1
Ge, C, Che, L, Ren, J, Pandita, RK, Lu, J, Li, K, Pandita, TK & Du, C 2015, Proceedings of the National Academy of Sciences of the United States of America, vol 112, no. 11, pp. E1210-E1219. DOI:

Single-strand DNA-binding protein SSB1 facilitates TERT recruitment to telomeres and maintains telomere G-overhangs
Pandita, RK, Chow, TT, Udayakumar, D, Bain, AL, Cubeddu, L, Hunt, CR, Shi, W, Horikoshi, N, Zhao, Y, Wright, WE, Khanna, KK, Shay, JW & Pandita, TK 2015, Cancer Research, vol 75, no. 5, pp. 858-869. DOI:

A Perspective on Chromosomal Double Strand Break Markers in Mammalian Cells
Wang, H, Adhikari, S, Butler, EB, Pandita, TK, Mitra, S & Hegde, ML 2015, Jacobs Journal of Radiation Oncology, vol 1, no. 1:003..

Targeted inhibition of histone deacetylases and hedgehog signaling suppress tumor growth and homologous recombination in aerodigestive cancers
Chun, SG, Park, H, Pandita, RK, Horikoshi, N, Pandita, TK, Schwartz, DL & Yordy, JS 2015, BMC Cancer, vol 5, no. 4, pp. 1337-52.

Role of the exocyst complex component Sec6/8 in genomic stability
Torres, MJ, Pandita, RK, Kulak, O, Kumar, R, Formstecher, E, Horikoshi, N, Mujoo, K, Hunt, CR, Zhao, Y, Lum, L, Zaman, A, Yeaman, C, White, MA & Pandita, TK 2015, Molecular and Cellular Biology, vol 35, no. 21, pp. 3633-3645. DOI:

Detecting ATM-dependent chromatin modification in DNA damage response
Udayakumar, D, Horikoshi, N, Mishra, L, Hunt, C & Pandita, TK 2015, Methods in Molecular Biology, vol 1288, pp. 317-336. DOI:

The Role of the Mammalian DNA End-processing Enzyme Polynucleotide Kinase 3’-Phosphatase in Spinocerebellar Ataxia Type 3 Pathogenesis
Chatterjee, A, Saha, S, Chakraborty, A, Silva-Fernandes, A, Mandal, SM, Neves-Carvalho, A, Liu, Y, Pandita, RK, Hegde, ML, Hegde, PM, Boldogh, I, Ashizawa, T, Koeppen, AH, Pandita, TK, Maciel, P, Sarkar, PS & Hazra, TK 2015, PLoS Genetics, vol 11, no. 1, e1004749. DOI:

Telomeres and Telomerase
Singh, DK, Mattoo, AR & Pandita, TK 2014, . in Reference Module in Biomedical Research. Elsevier Inc. DOI: