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Stephen T. Wong, PhD

John S. Dunn, Sr. Presidential Distinguished Chair in Biomedical Engineering, Department of Systems Medicine & Bioengineering
Professor of Systems Medicine and Bioengineering, Institute for Academic Medicine
Full Member, Research Institute
Houston Methodist
Weill Cornell Medical College


stwong@houstonmethodist.org
Biography

Dr. Wong is the Founding Chairman for Department of Systems Medicine and Bioengineering, Houston Methodist Research Institute. He holds the John S. Dunn, Sr. Distinguished Endowed Chair in Biomedical Engineering; he is also a Professor of Radiology, Pathology, Laboratory Medicine, Neurology, and Neurosciences, the Associate Director of Translational Research at Methodist Cancer Center, and Chief of Medical Physics and Chief Research Information Officer at Houston Methodist Hospital. In addition, he serves as the Founding Director of the Ting Tsung and Wei Fong Chao Center for BRAIN (Bioinformatics Research and Imaging in the Neurosciences) and Founding Director of the Center for Modeling Cancer Development at Houston Methodist Research Institute. He also holds a dozen of other academic posts across institutions in Texas Medical Center as well as overseas universities and medical schools. An internationally acclaimed bioengineer and imaging scientist, Dr. Stephen Wong has led teams that developed production automation for first very large scale integration (VLSI) 1MB computer memory chip and the largest online brokerage trading system, and contributed to the first hospital-wide digital radiology image management system in US academic medical centers.

Dr. Wong has more than twenty years of research and management experience in industry and academia, including Hewlett-Packard, AT&T Bell Laboratories, the Japanese Fifth Generation Computer Systems Project, Philips Medical Systems and Royal Philips Electronics, Charles Schwab, University of California - San Francisco/Berkeley, Harvard University and The Methodist Hospital. He received his senior executive education from the MIT Sloan School of Management, Stanford University Graduate School of Business and Columbia University Graduate School of Business. He holds eight patents and has published over 300 peer-reviewed papers and four books. He also serves on and chairs NIH study panels, conference program committees, and the editorial boards of twelve scientific journals. As an international authority, he is sought as a speaker on medical imaging, systems biology, healthcare IT, drug development, biophotonics, clinical neuroscience and other related topics.

Description of Research

Dr. Wong's research focuses on understanding health and disease from a systems perspective in order to generate cost-effective strategies and solutions for disease management. His research approaches combine both experimental and high throughput biology with rigorous computational, bioinformatics, biophysics, and imaging methods to achieve a deep understanding of the functions of each component in biological systems and integration of them with multilevel systems analysis. For example, the consequences of genetic variation, cell-cell interactions and environmental factors are included to reflect the circumstances and microenvironments of the disease condition. Current research projects include pathway modeling and high throughput phenotyping approaches for target discovery and drug repurposing in combating neurological disorders and cancer, and for understanding the mechanisms of these diseases. Additional projects include reformulation of small molecule drugs using chemical biology approaches, the development of point-of-care molecular diagnosis and monitoring devices using biophotonics and nanotechnology techniques, and the development of label-free molecular image-guided cancer therapy platforms.

Areas Of Expertise

Biological and medical imaging Bioinformatics Systems biology Drug repositioning Drug combinations Image-guided therapy Translational biophotonics Molecular imaging Diagnosis Mechanisms of cancer Mechanisms of neurological disorders
Education & Training

Postdoctoral Fellowship , Japan Science and Technology Agency
MS , Lehigh University
PhD , Lehigh University
Postdoctoral Fellowship , National Science Foundation, ICOT, The Fifth Generation Computer Systems Project, MITI, Tokyo
Publications

Comparison of Direct Patient Care Costs and Quality Outcomes of the Teaching and Non-Teaching Hospitalist Services at a Large Academic Medical Center
Perez, JA, Awar, M, Nezamabadi, A, Ogunti, R, Puppala, M, Colton, L, Clewing, JM, Ketkar, S, Wong, STC & Robbins, RJ 2017, Academic medicine : journal of the Association of American Medical Colleges. DOI: 10.1097/ACM.0000000000002026

Role of platelet-derived Tgfß1 in the progression of ovarian cancer
Hu, Q, Hisamatsu, T, Haemmerle, M, Cho, MS, Pradeep, S, Rupaimoole, R, Rodriguez-Aguayo, C, Lopez-Berestein, G, Wong, STC, Sood, AK & Afshar-Kharghan, V 2017, Clinical Cancer Research, vol 23, no. 18, pp. 5611-5621. DOI: 10.1158/1078-0432.CCR-16-3272

Early clearance vs persistence of de novo donor-specific antibodies following lung transplantation
Islam, AK, Sinha, N, DeVos, JM, Kaleekal, TS, Jyothula, SS, Teeter, LD, Nguyen, DTM, Eagar, TN, Moore, LW, Puppala, M, Wong, STC, Knight, RJ, Frost, AE, Graviss, EA & Osama Gaber, A 2017, Clinical Transplantation. DOI: 10.1111/ctr.13028

Prevalence of in-hospital nonsteroidal antiinflammatory drug exposure in patients with a primary diagnosis of heart failure
Alvarez, PA, Putney, D, Ogunti, R, Puppala, M, Ganduglia, C, Torre-Amione, G, Schutt, R, Wong, STC & Estep, JD 2017, Cardiovascular Therapeutics, vol 35, no. 3. DOI: 10.1111/1755-5922.12256

Complete Metabolic Response on Interim (18)F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography to Predict Long-Term Survival in Patients with Breast Cancer Undergoing Neoadjuvant Chemotherapy
Chen, S, Ibrahim, NK, Yan, Y, Wong, ST, Wang, H & Wong, FC 2017, Oncologist, vol 22, no. 5, pp. 526-534. DOI: 10.1634/theoncologist.2016-0334

Bone-in-culture array as a platform to model early-stage bone metastases and discover anti-metastasis therapies
Wang, H, Tian, L, Goldstein, A, Liu, J, Lo, H-C, Sheng, K, Welte, T, Wong, STC, Gugala, Z, Stossi, F, Zong, C, Li, Z, Mancini, MA & Zhang, XHF 2017, Nature communications, vol 8, pp. 15045. DOI: 10.1038/ncomms15045

Transductive local fisher discriminant analysis for gene expression profile-based cancer classification
Li, D, Wang, L, Wang, J, Xue, Z & Wong, STC 2017, . in 2017 IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2017., 7897202, IEEE, pp. 49-52, 4th IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2017, Orlando, United States, 16-19 February. DOI: 10.1109/BHI.2017.7897202

Deep learning analytics for diagnostic support of breast cancer disease management
He, T, Puppala, M, Ogunti, R, Mancuso, JJ, Yu, X, Chen, S, Chang, JC, Patel, TA & Wong, STC 2017, . in 2017 IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2017., 7897281, IEEE, pp. 365-368, 4th IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2017, Orlando, United States, 16-19 February. DOI: 10.1109/BHI.2017.7897281

Precise calibration for the coordinates of surgical needle's tip based on transform invariant matrix and spherical constraints
Jin, J, Zhang, L, Wang, H, Wong, STC & Li, H 2017, . in 2017 IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2017., 7897298, IEEE, pp. 433-436, 4th IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2017, Orlando, United States, 16-19 February. DOI: 10.1109/BHI.2017.7897298

Welcome message: 4th IEEE International Conference on Biomedical Health Informatics (BHI2017)
Wong, STC, Wang, MD & Laine, AF 2017, 2017 IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2017. DOI: 10.1109/BHI.2017.7897180

Subarachnoid hemorrhage - Induced block of cerebrospinal fluid flow: Role of brain coagulation factor III (tissue factor)
Golanov, EV, Bovshik, E, Wong, K, Pautler, RG, Foster, C, Federley, R, Zhang, YJ, Mancuso, J, Wong, ST & Britz, GW 2017, Journal of Cerebral Blood Flow and Metabolism. DOI: 10.1177/0271678X17701157

Dynamic respiratory motion estimation using patch-based kernel-pca priors for lung cancer Radiotherapy
He, T, Pino, R, Teh, B, Wong, S & Xue, Z 2017, . in Molecular Imaging, Reconstruction and Analysis of Moving Body Organs, and Stroke Imaging and Treatment - 5th International Workshop, CMMI 2017 2nd International Workshop, RAMBO 2017 and 1st International Workshop, SWITCH 2017 Held in Conjunction with MICCAI 2017, Proceedings. vol. 10555 LNCS, Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 10555 LNCS, Springer Verlag, pp. 55-65, 5th International Workshop on Computational Methods for Molecular Imaging, CMMI 2017, 2nd International Workshop on Reconstruction and Analysis of Moving Body Organs, RAMBO 2017 and 1st International Stroke Workshop on Imaging and Treatment Challenges, SWITCH 2017 held in Conjunction with 20th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2017, Quebec City, Canada, 14-14 September. DOI: 10.1007/978-3-319-67564-0_6

Technical pitfalls of signal truncation in perfusion MRI of glioblastoma
Wong, KK , Fung, SH , New, PZ & Wong, STC 2016, Frontiers in Neurology, vol 7, no. AUG, 121, pp. 121. DOI: 10.3389/fneur.2016.00121

Dual CARS and SHG image acquisition scheme that combines single central fiber and multimode fiber bundle to collect and differentiate backward and forward generated photons
Weng, S, Chen, X, Xu, X, Wong, KK & Wong, STC 2016, Biomedical Optics Express, vol 7, no. 6, pp. 2202-2218. DOI: 10.1364/BOE.7.002202

Cell type-dependent Erk-Akt pathway crosstalk regulates the proliferation of fetal neural progenitor cells
Rhim, JH, Luo, X, Gao, D, Xu, X, Zhou, T, Li, F, Wang, P, Wong, STC & Xia, X 2016, Scientific Reports, vol 6, 26547. DOI: 10.1038/srep26547

Welcome message: 3rd IEEE EMBS International Conference on Biomedical and Health Informatics
Wong, STC & Sloane, E 2016, . in Journal of Biomedical and Health Informatics., 7455809, IEEE, 3rd IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2016, Las Vegas, United States, 24-27 February. DOI: 10.1109/BHI.2016.7455809

A three-dimensional medical image segmentation app using graphic theory
He, T, Xue, Z & Wong, ST 2016, . in 3rd IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2016., 7455886, IEEE, pp. 268-271, 3rd IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2016, Las Vegas, United States, 24-27 February. DOI: 10.1109/BHI.2016.7455886

DrugMoaMiner: A computational tool for mechanism of action discovery and personalized drug sensitivity prediction
Li, F, Wang, L, Kong, R, Sheng, J, Cao, H, Mancuso, J, Xia, X, Stephan, C & Wong, STC 2016, . in 3rd IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2016., 7455911, IEEE, pp. 368-371, 3rd IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2016, Las Vegas, United States, 24-27 February. DOI: 10.1109/BHI.2016.7455911

A smartphone app framework for segmented cancer care coordination
He, T, Ogunti, R, Puppala, M, Chen, S, Yu, X, Mancuso, JJ & Wong, STC 2016, . in 3rd IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2016., 7455912, IEEE, pp. 372-375, 3rd IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2016, Las Vegas, United States, 24-27 February. DOI: 10.1109/BHI.2016.7455912

Data security and privacy management in healthcare applications and clinical data warehouse environment
Puppala, M, He, T, Yu, X, Chen, S, Ogunti, R & Wong, STC 2016, . in 3rd IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2016., 7455821, IEEE, pp. 5-8, 3rd IEEE EMBS International Conference on Biomedical and Health Informatics, BHI 2016, Las Vegas, United States, 24-27 February. DOI: 10.1109/BHI.2016.7455821