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Stephen L. Jones, MD, MSHI

John F., Jr. and Carolyn Bookout Distinguished Professor in Surgical Quality and Outcomes Science, Department of Surgery
Assistant Professor of Clinical Surgery, Institute for Academic Medicine
Assistant Clinical Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Stephen L. Jones, M.D., M.S.H.I. is a medical informaticist dedicated to raising the standard of care for all patients worldwide. He joined the Department of Surgery and The Houston Methodist Research Institute in July of 2007 after spending the prior 7 years in the medical software industry. While in industry, he held many management roles including co-founder and president of a start-up company. He later served as the clinical systems architect for a  practice management and electronic health records company. He has many years of experience designing effective software information systems and managing distributed support and development teams. Software designed, written and developed by teams managed by Dr. Jones is currently responsible for safely and efficiently ePrescribing over 100K prescriptions per month across the nation. He graduated from the University of Texas Health Science Center at Houston Medical School in 1995 and entered an internal medicine residency program at his home institution. It was during this time that he was first exposed to the field of medical informatics and found his true calling in medicine: clinical informatics and decision support leveraging technology to improve health and raise the standard of care. Since joining the Department of Surgery at Houston Methodist Hospital in 2007 he has completed a Master of Science in Health Informatics at The University of Texas School of Biomedical Sciences and completed a post-doctoral fellowship sponsored by the NLM and administered through the Gulf Coast Consortia and the Keck Center for Interdisciplinary Bioscience training  at Rice University (NLM Grant No. 5T15LM007093). The NLM fellowship provided invaluable training for working within interdisciplinary teams and multi-institutional projects. His fellowship project was to architect an innovative semi-automated early sepsis screening system, created by Dr. Laura J. Moore and Dr. Fred A. Moore in the Division of Acute and Critical Care Surgery at HMH, to identify patients at risk for developing sepsis while they are hospitalized. The fellowship project tool and research are a central part of an initiative that has saved over 900 lives during the past 7 years at Houston Methodist Hospital and is an integral part of the Sepsis Early Recognition and Response Initiative (SERRI) funded by the CMS Health Care Innovations Challenge (CMS-1C1-12-0001) for $14.3M over a 4 year period. Dr. Jones currently serves as the Chief Clinical Informatics Officer for the Department of Surgery at Houston Methodist Hospital and Division Chief of Health Informatics – Center for Outcomes Research, Houston Methodist Research Institute. He is an Assistant Professor of Clinical Informatics in Surgery, Weill Cornell Medical College. Since 2007 he has co-authored over a dozen peer reviewed papers, one of which has been cited by the Committee on Patient Safety and Health Information Technology; Institute of Medicine, Health IT and Patient Safety: Building Safer Systems for Better Care. Washington, D.C.: The National Academies Press, 2011.

Description of Research

Dr. Jones' research centers on the development of customized clinical informatics systems and databases for clinical practice and research.

Areas Of Expertise

Clinical informatics Quality outcomes Database development Comparative-effectiveness research

Sepsis as 2 problems: Identifying sepsis at admission and predicting onset in the hospital using an electronic medical record-based acuity score
Rothman, M, Levy, M, Dellinger, RP, Jones, SL, Fogerty, RL, Voelker, KG, Gross, B, Marchetti, A & Beals, J 2016, Journal of Critical Care, vol 38, pp. 237-244. DOI:

The sepsis early recognition and response initiative (SERRI)
Jones, SL , Ashton, CM, Kiehne, L, Gigliotti, E, Bell-Gordon, C, Pinn, TT, Tran, SK, Nicolas, JC, Rose, AL, Shirkey, BA, Disbot, M, Masud, F & Wray, NP 2016, Joint Commission Journal on Quality and Patient Safety, vol 42, no. 3, pp. 122-131. DOI:

Outcomes and resource use of sepsis-associated stays by presence on admission, severity, and hospital type
Jones, SL , Ashton, CM, Kiehne, LB, Nicolas, JC, Rose, AL, Shirkey, BA, Masud, F & Wray, NP 2016, Medical Care, vol 54, no. 3, pp. 303-310. DOI:

Reductions in Sepsis Mortality and Costs After Design and Implementation of a Nurse-Based Early Recognition and Response Program
Jones, SL , Ashton, CM, Kiehne, L, Gigliotti, E, Bell-Gordon, C, Disbot, M, Masud, F, Shirkey, BA & Wray, NP 2015, Joint Commission Journal on Quality and Patient Safety / Joint Commission Resources, vol 41, no. 11, pp. 483-491.

Death, taxes and advance directives
Wood, NM, DAmore, JD, Jones, SL, Sittig, DF & Ness, RB 2014, Applied Clinical Informatics, vol 5, no. 2, pp. 589-593. DOI:

Surgeon-specific performance reports in general surgery: An observational study of initial implementation and adoption
Yi, SG, Wray, NP, Jones, SL, Bass, BL, Nishioka, J, Brann, S & Ashton, CM 2013, Journal of the American College of Surgeons, vol 217, no. 4. DOI:

The Effect of Adrenal Replacement Therapy on Rates of Fungal Colonization and Mortality in Critically Ill Patients Awaiting Liver Transplantation
Yi, SG, Sadhu, AR, Jones, SL, Turner, K, Monsour, H, Donahue, K, Xia, X, Gaber, AO, Ghobrial, RM & Burroughs, SG 2013, Journal of clinical and translational hepatology, vol 1, no. 1, pp. 2-8. DOI:

Cross-sectional and case-control analyses of the association of kidney function staging with adverse postoperative outcomes in general and vascular surgery
Gaber, AO , Moore, LW, Aloia, TA, Suki, WN, Jones, SL, Graviss, EA, Knight, RJ & Bass, BL 2013, Annals of Surgery, vol 258, no. 1, pp. 169-177. DOI:

Which skills really matter? proving face, content, and construct validity for a commercial robotic simulator
Lyons, C, Goldfarb, D, Jones, SL, Badhiwala, N, Miles, B, Link, R & Dunkin, BJ 2013, Surgical Endoscopy and Other Interventional Techniques, vol 27, no. 6, pp. 2020-2030. DOI:

The mean dietary protein intake at different stages of chronic kidney disease is higher than current guidelines
Moore, LW, Byham-Gray, LD, Scott Parrott, J, Rigassio-Radler, D, Mandayam, S, Jones, SL, Mitch, WE & Osama Gaber, A 2013, Kidney International, vol 83, no. 4, pp. 724-732. DOI:

Nucleated red blood cells are associated with a higher mortality rate in patients with surgical sepsis
Desai, S, Jones, SL, Turner, KL, Hall, J & Moore, LJ 2012, Surgical Infections, vol 13, no. 6, pp. 360-365. DOI:

Erratum to " Cross-terminology mapping challenges: A demonstration using medication terminological systems" [J. Biomed. Inform. (2012) 613-625]
Saitwal, H, Qing, D, Jones, S, Bernstam, EV, Chute, CG & Johnson, TR 2012, Journal of Biomedical Informatics, vol 45, no. 6. DOI:

Cross-terminology mapping challenges: A demonstration using medication terminological systems
Saitwal, H, Qing, D, Jones, S, Bernstam, EV, Chute, CG & Johnson, TR 2012, Journal of Biomedical Informatics, vol 45, no. 4, pp. 613-625. DOI:

Robotic telepresence: A helpful adjunct that is viewed favorably by critically ill surgical patients
Sucher, JF, Todd, SR, Jones, SL, Throckmorton, T, Turner, KL & Moore, FA 2011, American Journal of Surgery, vol 202, no. 6, pp. 843-847. DOI:

Availability of acute care surgeons improves outcomes in patients requiring emergent colon surgery
Moore, LJ, Turner, KL, Jones, SL, Fahy, BN & Moore, FA 2011, American Journal of Surgery, vol 202, no. 6, pp. 837-842. DOI:

Review of reported clinical information system adverse events in US food and drug administration databases
Myers, RB, Jones, SL & Sittig, DF 2011, Applied Clinical Informatics, vol 2, no. 1, pp. 63-74. DOI:

Identification of cardiac dysfunction in sepsis with B-type natriuretic peptide
Turner, KL, Moore, LJ, Todd, SR, Sucher, JF, Jones, SA, McKinley, BA, Valdivia, A, Sailors, RM & Moore, FA 2011, Journal of the American College of Surgeons, vol 213, no. 1, pp. 139-146. DOI:

Sepsis in general surgery: The 2005-2007 national surgical quality improvement program perspective
Moore, LJ, Moore, FA, Todd, SR, Jones, SL, Turner, KL & Bass, BL 2010, Archives of Surgery, vol 145, no. 7, pp. 695-700. DOI:

Sepsis in general surgery: a deadly complication
Moore, LJ, Moore, FA, Jones, SL, Xu, J & Bass, BL 2009, American Journal of Surgery, vol 198, no. 6, pp. 868-874. DOI:

Chemotherapy within 30 days prior to liver resection does not increase postoperative morbidity or mortality
Fahy, BN, Aloia, TA, Jones, SL, Bass, BL & Fischer, CP 2009, HPB, vol 11, no. 8, pp. 645-655. DOI: