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Stephen Beres, PhD

Associate Professor of Pathology and Genomic Medicine, Institute for Academic Medicine
Associate Member, Research Institute
Houston Methodist


Genomic Landscape of Intrahost Variation in Group A Streptococcus: Repeated and Abundant Mutational Inactivation of the fabT Gene Encoding a Regulator of Fatty Acid Synthesis
Eraso, JM, Olsen, RJ, Beres, SB, Kachroo, P, Porter, AR, Nasser, W, Bernard, PE, DeLeo, FR & Musser, JM 2016, Infection and Immunity, vol 84, no. 12, pp. 3268-3281. DOI:

Transcriptome remodeling contributes to epidemic disease caused by the human pathogen Streptococcus pyogenes
Beres, SB, Kachroo, P, Nasser, W, Olsen, RJ, Zhu, L, Flores, AR, de la Riva, I, Paez-Mayorga, J, Jimenez, FE, Cantu, C, Vuopio, J, Jalava, J, Kristinsson, KG, Gottfredsson, M, Corander, J, Fittipaldi, N, Di Luca, MC, Petrelli, D, Vitali, LA, Raiford, A, Jenkins, L & Musser, JM 2016, mBio, vol 7, no. 3, e00403-16. DOI:

A molecular trigger for intercontinental epidemics of group A Streptococcus
Zhu, L, Olsen, RJ, Nasser, W, Beres, SB, Vuopio, J, Kristinsson, KG, Gottfredsson, M, Porter, AR, DeLeo, FR & Musser, JM 2015, The Journal of clinical investigation, vol 125, no. 9, pp. 3545-3559. DOI:

Comparative whole genome sequencing of community-associated methicillin-resistant Staphylococcus aureus sequence type 8 from primary care clinics in a Texas community
Lee, GC, Long, SW, Musser, JM, Beres, SB, Olsen, RJ, Dallas, SD, Nunez, YO & Frei, CR 2015, Pharmacotherapy, vol 35, no. 2, pp. 220-228. DOI:

The majority of 9,729 group A streptococcus strains causing disease secrete SpeB cysteine protease: Pathogenesis implications
Olsen, RJ, Raghuram, A, Cantu, C, Hartman, MH, Jimenez, FE, Lee, S, Ngo, A, Rice, KA, Saddington, D, Spillman, H, Valson, C, Flores, AR, Beres, SB, Wesley Long, S, Nasser, W & Musser, JM 2015, Infection and Immunity, vol 83, no. 12, pp. 4750-4758. DOI:

Absence of Patient-to-Patient intrahospital transmission of staphylococcus aureus as determined by Whole-Genome sequencing
Wesley Long, S , Beres, SB , Olsen, RJ & Musser, JM 2014, mBio, vol 5, no. 5, e01692-1. DOI:

Evolutionary pathway to increased virulence and epidemic group A Streptococcus disease derived from 3,615 genome sequences
Nasser, W, Beres, SB, Olsen, RJ, Dean, MA, Rice, KA, Long, SW, Kristinsson, KG, Gottfredsson, M, Vuopio, J, Raisanen, K, Caugant, DA, Steinbakk, M, Low, DE, McGeer, A, Darenberg, J, Henriques-Normark, B, Van Beneden, CA, Hoffmann, S & Musser, JM 2014, Proceedings of the National Academy of Sciences of the United States of America, vol 111, no. 17. DOI:

Clinical laboratory response to a mock outbreak of invasive bacterial infections: A preparedness study
Olsen, RJ, Fittipaldi, N, Kachroo, P, Sanson, MA, Long, SW, Como-Sabetti, KJ, Valson, C, Cantu, C, Lynfield, R, Van Beneden, C, Beres, SB & Musser, JM 2014, Journal of Clinical Microbiology, vol 52, no. 12, pp. 4210-4216. DOI:

Asymptomatic carriage of group A streptococcus is associated with elimination of capsule production
Flores, AR, Jewell, BE, Olsen, RJ, Shelburne, SA, Fittipaldi, N, Beres, SB & Musser, JM 2014, Infection and Immunity, vol 82, no. 9, pp. 3958-3967. DOI:

Natural disruption of two regulatory networks in serotype M3 Group A Streptococcus isolates contributes to the virulence factor profile of this hypervirulent serotype
Cao, TN, Liu, Z, Cao, TH, Pflughoeft, KJ, Treviño, J, Danger, JL, Beres, SB, Musser, JM & Sumby, P 2014, Infection and Immunity, vol 82, no. 5, pp. 1744-1754. DOI:

High-throughput RNA sequencing of a formalin-fixed, paraffin-embedded autopsy lung tissue sample from the 1918 influenza pandemic
Xiao, YL, Kash, JC, Beres, SB, Sheng, ZM, Musser, JM & Taubenberger, JK 2013, Journal of Pathology, vol 229, no. 4, pp. 535-545. DOI:

Human disease isolates of serotype m4 and m22 group a streptococcus lack genes required for hyaluronic acid capsule biosynthesis.
Flores, AR, Jewell, BE, Fittipaldi, N, Beres, SB & Musser, JM 2012, mBio, vol 3, no. 6.

Human disease isolates of serotype M4 and M22 group A streptococcus lack genes required for hyaluronic acid capsule biosynthesis
Flores, AR, Jewell, BE, Fittipaldi, N, Beres, SB & Musser, JM 2012, mBio, vol 3, no. 6. DOI:

Polymorphisms in regulator of protease B (RopB) alter disease phenotype and strain virulence of serotype M3 group a streptococcus
Olsen, RJ, Laucirica, DR, Watkins, ME, Feske, ML, Garcia-Bustillos, JR, Vu, C, Cantu, C, Shelburne, SA, Fittipaldi, N, Kumaraswami, M, Shea, PR, Flores, AR, Beres, SB, Lovgren, M, Tyrrell, GJ, Efstratiou, A, Low, DE, Van Beneden, CA & Musser, JM 2012, Journal of Infectious Diseases, vol 205, no. 11, pp. 1719-1729. DOI:

Genomic analysis of emm59 group a Streptococcus invasive strains, United States
Fittipaldi, N, Olsen, RJ, Beres, SB, van Beneden, C & Musser, JM 2012, Emerging Infectious Diseases, vol 18, no. 4, pp. 650-652. DOI:

Full-genome dissection of an epidemic of severe invasive disease caused by a hypervirulent, recently emerged clone of group A Streptococcus
Fittipaldi, N, Beres, SB, Olsen, RJ, Kapur, V, Shea, PR, Watkins, ME, Cantu, CC, Laucirica, DR, Jenkins, L, Flores, AR, Lovgren, M, Ardanuy, C, Liares, J, Low, DE, Tyrrell, GJ & Musser, JM 2012, American Journal of Pathology, vol 180, no. 4, pp. 1522-1534. DOI:

Rapidly progressive, fatal, inhalation anthrax-like infection in a human: Case report, pathogen genome sequencing, pathology, and coordinated response
Wright, AM, Beres, SB, Consamus, EN, Long, SW, Flores, AR, Barrios, R, Richter, GS, Oh, SY, Garufi, G, Maier, H, Drews, AL, Stockbauer, KE, Cernoch, P, Schneewind, O, Olsen, RJ & Musser, JM 2011, Archives of Pathology and Laboratory Medicine, vol 135, no. 11, pp. 1447-1459. DOI:

Group a streptococcus emm gene types in pharyngeal isolates, Ontario, Canada, 2002-2010
Shea, PR, Ewbank, AL, Gonzalez-Lugo, JH, Martagon-Rosado, AJ, Martinez-Gutierrez, JC, Rehman, HA, Serrano-Gonzalez, M, Fittipaldi, N, Beres, SB, Flores, AR, Low, DE, Willey, BM & Musser, JM 2011, Emerging Infectious Diseases, vol 17, no. 11, pp. 2010-2017. DOI:

Evolution of diversity in epidemics revealed by analysis of the human bacterial pathogen group A Streptococcus
Carroll, RK, Beres, SB, Sitkiewicz, I, Peterson, L, Matsunami, RK, Engler, DA, Flores, AR, Sumby, P & Musser, JM 2011, Epidemics, vol 3, no. 3-4, pp. 159-170. DOI:

Naturally occurring single amino acid replacements in a regulatory protein alter streptococcal gene expression and virulence in mice
Carroll, RK, Shelburne, SA, Olsen, RJ, Suber, B, Sahasrabhojane, P, Kumaraswami, M, Beres, SB, Shea, PR, Flores, AR & Musser, JM 2011, Journal of Clinical Investigation, vol 121, no. 5, pp. 1956-1968. DOI: