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Shu-Hsia Chen, PhD

Emily Herrmann Chair in Immunology Research, Cancer Center
Director, Center for Immunotherapy Research
Houston Methodist


Biography

Shu-Hsia Chen, Ph.D., is the Emily Hermann endowed Professor in cancer immunotherapy, director of Cancer Immunotherapy Research Center and Immune Assessment Core at the Methodist Research Institute. Prior to joining Houston Methodist, she was a tenured Professor in the Department of Oncological Sciences and Surgery in the Icahn School of Medicine at Mount Sinai in New York. She obtained her PhD from National Yang-Ming Medical University in Taiwan in 1993 and finished her fellowship training at the Howard Hughes Medical Institute. In 1996, she assumed the role of Assistant Professor in the Department of Cell Biology at Baylor College of Medicine in Houston. She has made significant contributions to the fields of gene therapy and cancer immunotherapy. Dr. Chen invented adenoviral gene delivery of suicide and immune modulatory genes for use in cancer immune therapies. Subsequently, she identified myeloid derived suppressor cell (MDSC) populations and has played an integral role in demonstrating MDSC-mediated suppression of antitumor T cell immune responses, identifying the tumor factors involved in MDSC expansion/accumulation, and discovering MDSC-mediated regulatory T cell activation in the tumor microenvironment. Furthermore, Dr. Chen identified the novel immune checkpoint receptors on MDSC population and was able to reprogram the myeloid cell differentiation, thereby modulating the tumor microenvironment. Her current research focuses on overcoming immune suppression in the tumor microenvironment, controlling MDSC/tumor associated macrophage differentiation, and developing effective immune therapeutic strategies for clinical use in cancer and autoimmune diseases. Dr. Chen is a world-class researcher and has done pioneering work in the field of gene therapy and immunotherapy, as demonstrated by her several inventions. She has also served on national and international grant review committees and as a reviewer/consultant for multiple international journals, institutes, and cancer centers. Her laboratory has published high-impact research articles in the field and her research has been continuously supported by multiple NIH grants, DOD grants, and pharmaceutical companies.

Publications

Leukocyte immunoglobulin-like receptors in human diseases: An overview of their distribution, function, and potential application for immunotherapies
Zhang, J, Mai, S, Chen, HM, Kang, K, Li, XC, Chen, SH & Pan, PY 2017, Journal of Leukocyte Biology, vol 102, no. 2, pp. 351-360. DOI: 10.1189/jlb.5MR1216-534R

LILRB receptor-mediated regulation of myeloid cell maturation and function
van der Touw, W, Chen, HM, Pan, PY & Chen, SH 2017, Cancer Immunology, Immunotherapy, pp. 1-9. DOI: 10.1007/s00262-017-2023-x

Leukocyte immunoglobulin-like receptors in human diseases: An overview of their distribution, function, and potential application for immunotherapies
Zhang, J, Mai, S, Chen, HM, Kang, K, Li, XC, Chen, SH & Pan, PY 2017, Journal of Leukocyte Biology, vol 102, no. 2, pp. 351-360. DOI: 10.1189/jlb.5MR1216-534R

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards
Bronte, V, Brandau, S, Chen, SH, Colombo, MP, Frey, AB, Greten, TF, Mandruzzato, S, Murray, PJ, Ochoa, A, Ostrand-Rosenberg, S, Rodriguez, PC, Sica, A, Umansky, V, Vonderheide, RH & Gabrilovich, DI 2016, Nature Communications, vol 7, 12150. DOI: 10.1038/ncomms12150

5-Fluorouracil targets thymidylate synthase in the selective suppression of TH17 cell differentiation
Wang, J, Peng, L, Zhang, R, Zheng, Z, Chen, C, Cheung, KL, Cui, M, Bian, G, Xu, F, Chiang, D, Hu, Y, Chen, Y, Lu, G, Yang, J, Zhang, H, Yang, J, Zhu, H, Chen, SH, Liu, K, Zhou, MM, Sikora, AG, Li, L, Jiang, B & Xiong, H 2016, Oncotarget, vol 7, no. 15, pp. 19312-19326. DOI: 10.18632/oncotarget.8344

Myeloid-derived suppressor cells as an immune parameter in patients with concurrent sunitinib and stereotactic body radiotherapy
Chen, HM, Ma, G, Gildener-Leapman, N, Eisenstein, S, Coakley, BA, Ozao, J, Mandeli, J, Divino, C, Schwartz, M, Sung, M, Ferris, R, Kao, J, Wang, LH, Pan, PY, Ko, EC & Chen, SH 2015, Clinical Cancer Research, vol 21, no. 18, pp. 4073-4085. DOI: 10.1158/1078-0432.CCR-14-2742

DC-SIGN+ Macrophages Control the Induction of Transplantation Tolerance
Conde, P, Rodriguez, M, van der Touw, W, Jimenez, A, Burns, M, Miller, J, Brahmachary, M, Chen, HM, Boros, P, Rausell-Palamos, F, Yun, TJ, Riquelme, P, Rastrojo, A, Aguado, B, Stein-Streilein, J, Tanaka, M, Zhou, L, Zhang, J, Lowary, TL, Ginhoux, F, Park, CG, Cheong, C, Brody, J, Turley, SJ, Lira, SA, Bronte, V, Gordon, S, Heeger, PS, Merad, M, Hutchinson, J, Chen, SH & Ochando, J 2015, Immunity, vol 42, no. 6, pp. 1143-1158. DOI: 10.1016/j.immuni.2015.05.009

Immunizations with hepatitis B viral antigens and a TLR7/8 agonist adjuvant induce antigen-specific immune responses in HBV-transgenic mice
Wang, Y, Chen, K, Wu, Z, Liu, Y, Liu, S, Zou, Z, Chen, SH & Qu, C 2014, International Journal of Infectious Diseases, vol 29, pp. 31-36. DOI: 10.1016/j.ijid.2014.07.015

Concurrent sunitinib and stereotactic body radiotherapy for patients with oligometastases: Final report of a prospective clinical trial
Kao, J, Chen, CT, Tong, CCL, Packer, SH, Schwartz, M, Chen, SH & Sung, MW 2014, Targeted Oncology, vol 9, no. 2, pp. 145-153. DOI: 10.1007/s11523-013-0280-y

Myeloid-derived suppressor cells as a vehicle for tumor-specific oncolytic viral therapy
Eisenstein, S, Coakley, BA, Briley-Saebo, K, Ma, G, Chen, HM, Meseck, M, Ward, S, Divino, C, Woo, S, Chen, SH & Pan, PY 2013, Cancer Research, vol 73, no. 16, pp. 5003-5015. DOI: 10.1158/0008-5472.CAN-12-1597

T cell-derived inducible nitric oxide synthase switches offth17 cell differentiation
Yang, J, Zhang, R, Lu, G, Shen, Y, Peng, L, Zhu, C, Cui, M, Wang, W, Arnaboldi, P, Tang, M, Gupta, M, Qi, CF, Jayaraman, P, Zhu, H, Jiang, B, Chen, SH, He, JC, Ting, AT, Zhou, MM, Kuchroo, VK, Morse, HC, Ozato, K, Sikora, AG & Xiong, H 2013, Journal of Experimental Medicine, vol 210, no. 7, pp. 1447-1462. DOI: 10.1084/jem.20122494

Polarization and reprogramming of myeloid-derived suppressor cells
Yang, WC, Ma, G, Chen, SH & Pan, PY 2013, Journal of Molecular Cell Biology, vol 5, no. 3, pp. 207-209. DOI: 10.1093/jmcb/mjt009

Lymphatic vasculature mediates macrophage reverse cholesterol transport in mice
Martel, C, Li, W, Fulp, B, Platt, AM, Gautier, EL, Westerterp, M, Bittman, R, Tall, AR, Chen, SH, Thomas, MJ, Kreisel, D, Swartz, MA, Sorci-Thomas, MG & Randolph, GJ 2013, Journal of Clinical Investigation, vol 123, no. 4, pp. 1571-1579. DOI: 10.1172/JCI63685

Myeloid-derived suppressor cells as a trojan horse: A cellular vehicle for the delivery of oncolytic viruses
Pan, PY, Chen, HM & Chen, SH 2013, OncoImmunology, vol 2, no. 8, e25083. DOI: 10.4161/onci.25083

Programming of MDSC: New opportunities for targeted therapy
Svider, P, Chen, SH, Sikora, AG & Yang, WC 2013, . in The Tumor Immunoenvironment. vol. 9789400762176, Springer Netherlands, pp. 567-584. DOI: 10.1007/978-94-007-6217-6_24

Myeloid-derived suppressor cells in transplantation and cancer
Ochando, JC & Chen, SH 2012, Immunologic Research, vol 54, no. 1-3, pp. 275-285. DOI: 10.1007/s12026-012-8335-1

Erratum: Inhibitory receptors bind ANGPTLs and support blood stem cells and leukaemia development (Nature (2012) 485 (656-660) DOI: 10.1038/nature11095)
Zheng, J, Umikawa, M, Cui, C, Li, J, Chen, X, Zhang, C, Huynh, H, Kang, X, Silvany, R, Wan, X, Ye, J, Cant, AP, Chen, SH, Wang, HY, Sally Ward, E & Zhang, CC 2012, Nature, vol 488, no. 7413, pp. 684. DOI: 10.1038/nature11268

G-H2AX kinetics as a novel approach to high content screening for small molecule radiosensitizers
Fu, S, Yang, Y, Tirtha, D, Yen, Y, Zhou, BS, Zhou, MM, Ohlmeyer, M, Ko, EC, Cagan, R, Rosenstein, BS, Chen, SH & Kao, J 2012, PLoS ONE, vol 7, no. 6, e38465. DOI: 10.1371/journal.pone.0038465

Phase II trial of concurrent sunitinib and image-guided radiotherapy for oligometastases
Tong, CCL, Ko, EC, Sung, MW, Cesaretti, JA, Stock, RG, Packer, SH, Forsythe, K, Genden, EM, Schwartz, M, Lau, KHV, Galsky, M, Ozao-Choy, J, Chen, SH & Kao, J 2012, PLoS ONE, vol 7, no. 6, e36979. DOI: 10.1371/journal.pone.0036979

Tumor-expressed inducible nitric oxide synthase controls induction of functional myeloid-derived suppressor cells through modulation of vascular endothelial growth factor release
Jayaraman, P, Parikh, F, Lopez-Rivera, E, Hailemichael, Y, Clark, A, Ma, G, Cannan, D, Ramacher, M, Kato, M, Overwijk, WW, Chen, SH, Umansky, VY & Sikora, AG 2012, Journal of Immunology, vol 188, no. 11, pp. 5365-5376. DOI: 10.4049/jimmunol.1103553