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Shiladitya Sengupta, PhD

Assistant Research Professor of Radiation Oncology, Institute for Academic Medicine
Assistant Research Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Dr. Sengupta is an Assistant Research Member in the department of Radiation Oncology of Houston Methodist Research Institute, and is also affiliated to Houston Methodist Institute for Academic Medicine and Weill Cornell Medical College, New York as Assistant Research Professor. Before joining Houston Methodist in September 2013, he was a Research Scientist at University of Texas Medical Branch at Galveston. He was a 2011-2013 Keck Fellow of Gulf Coast Consortia's Computational Cancer Biology Training Program, funded by the Cancer Prevention and Research Institute of Texas. He received PhD in 2008 from Jadavpur University, India, and is also a recipient of 2007 Young Scientist Award from Indian Institute of Human Genetics. He also serves as a regular reviewer for DNA Repair, Mutation Research, Oncotarget, DNA and Cell Biology, etc.  

Description of Research

Dr. Sengupta supervises fresh graduate and undergraduate students in the Mitra laboratory.

Areas Of Expertise

Cell proliferation Drug resistance Transcription regulation Protein acetylation Genome damage response Genomic instability
Education & Training

PhD , Jadavpur University
MSc , University of Calcutta

Microhomology-mediated end joining is activated in irradiated human cells due to phosphorylation-dependent formation of the XRCC1 repair complex
Dutta, A, Eckelmann, B, Adhikari, S, Ahmed, KM, Sengupta, S, Pandey, A, Hegde, PM, Tsai, M-S, Tainer, JA, Weinfeld, M, Hegde, ML & Mitra, S 2016, Nucleic acids research. DOI:

Human AP-endonuclease (APE1) is acetylated at DNA damage sites in chromatin and acetylation modulates its DNA repair activity
Roychoudhury, S, Nath, S, Song, H, Hegde, ML, Bellot, LJ, Mantha, AK, Sengupta, S, Ray, S, Natarajan, A & Bhakat, KK 2016, Molecular and Cellular Biology. DOI:

Dynamic Microenvironment Induces Phenotypic Plasticity of Esophageal Cancer Cells under Flow
Kocal, GC, Güven, S, Foygel, K, Goldman, A, Chen, P, Sengupta, S, Paulmurugan, R, Baskin, Y & Demirci, U 2016, Scientific Reports, vol 6, 38221. DOI:

Regulation of oxidized base damage repair by chromatin assembly factor 1 subunit A
Yang, C , Sengupta, S, Hegde, PM, Mitra, J, Jiang, S, Holey, B, Sarker, AH, Tsai, M-S, Hegde, ML & Mitra, S 2016, Nucleic acids research, vol 45, no. 2, pp. 739-748. DOI:

Combining Immune Checkpoint Inhibitors and Kinase-Inhibiting Supramolecular Therapeutics for Enhanced Anticancer Efficacy
Kulkarni, A, Natarajan, SK, Chandrasekar, V, Pandey, PR & Sengupta, S 2016, ACS Nano, vol 10, no. 10, pp. 9227-9242. DOI:

Algorithm for Designing Nanoscale Supramolecular Therapeutics with Increased Anticancer Efficacy
Kulkarni, A, Pandey, P, Rao, P, Mahmoud, A, Goldman, A, Sabbisetti, V, Parcha, S, Natarajan, SK, Chandrasekar, V, Dinulescu, D, Roy, S & Sengupta, S 2016, ACS Nano, vol 10, no. 9, pp. 8154-8168. DOI:

Scaffold attachment factor A (SAF-A) and Ku temporally regulate repair of radiation-induced clustered genome lesions
Hegde, ML, Dutta, A, Yang, C, Mantha, AK, Hegde, PM, Pandey, A, Sengupta, S, Yu, Y, Calsou, P, Chen, D, Lees-Miller, SP & Mitra, S 2016, Oncotarget. DOI:

Regulation of limited N-terminal proteolysis of APE1 in tumor via acetylation and its role in cell proliferation
Bhakat, KK, Sengupta, S, Adeniyi, VF, Roychoudhury, S, Nath, S, Bellot, LJ, Feng, D, Mantha, AK, Sinha, M, Qiu, S & Luxon, BA 2016, Oncotarget. DOI:

Anti-platelet agents augment cisplatin nanoparticle cytotoxicity by enhancing tumor vasculature permeability and drug delivery
Pandey, A, Sarangi, S, Chien, K, Sengupta, P, Papa, AL, Basu, S & Sengupta, S 2014, Nanotechnology, vol 25, no. 44, 445101. DOI:

Sequential application of a cytotoxic nanoparticle and a PI3K inhibitor enhances antitumor efficacy
Pandey, A, Kulkarni, A, Roy, B, Goldman, A, Sarangi, S, Sengupta, P, Phipps, C, Kopparam, J, Oh, M, Basu, S, Kohandel, M & Sengupta, S 2014, Cancer Research, vol 74, no. 3, pp. 675-685. DOI:

PEGylated liposomal Gemcitabine: Insights into a potential breast cancer therapeutic
Papa, AL, Sidiqui, A, Balasubramanian, SUA, Sarangi, S, Luchette, M, Sengupta, S & Harfouche, R 2013, Cellular Oncology, vol 36, no. 6, pp. 449-457. DOI:

Supramolecular nanoparticles that target phosphoinositide-3-kinase overcome insulin resistance and exert pronounced antitumor efficacy
Kulkarni, AA, Roy, B, Rao, PS, Wyant, GA, Mahmoud, A, Ramachandran, M, Sengupta, P, Goldman, A, Kotamraju, VR, Basu, S, Mashelkar, RA, Ruoslahti, E, Dinulescu, DM & Sengupta, S 2013, Cancer Research, vol 73, no. 23, pp. 6987-6997. DOI:

P2Y12 receptor inhibition augments cytotoxic effects of cisplatin in breast cancer
Sarangi, S, Pandey, A, Papa, AL, Sengupta, P, Kopparam, J, Dadwal, U, Basu, S & Sengupta, S 2013, Medical Oncology, vol 30, no. 2, 567. DOI:

Design principles for clinical efficacy of cancer nanomedicine: A look into the basics
Sengupta, S & Kulkarni, A 2013, ACS Nano, vol 7, no. 4, pp. 2878-2882. DOI:

Mechanistic studies of Gemcitabine-loaded nanoplatforms in resistant pancreatic cancer cells
Papa, AL, Basu, S, Sengupta, P, Banerjee, D, Sengupta, S & Harfouche, R 2012, BMC Cancer, vol 12, 419. DOI:

Cholesterol-tethered platinum II-based supramolecular nanoparticle increases antitumor efficacy and reduces nephrotoxicity
Sengupta, P, Basu, S, Soni, S, Pandey, A, Roy, B, Oh, MS, Chin, KT, Paraskar, AS, Sarangi, S, Connor, Y, Sabbisetti, VS, Kopparam, J, Kulkarni, A, Muto, K, Amarasiriwardena, C, Jayawardene, I, Lupoli, N, Dinulescu, DM, Bonventre, JV, Mashelkar, RA & Sengupta, S 2012, Proceedings of the National Academy of Sciences of the United States of America, vol 109, no. 28, pp. 11294-11299. DOI:

Rationally designed oxaliplatin-nanoparticle for enhanced antitumor efficacy
Paraskar, A, Soni, S, Roy, B, Papa, AL & Sengupta, S 2012, Nanotechnology, vol 23, no. 7, 075103. DOI:

Insulin-like growth factors promote vasculogenesis in embryonic stem cells
Piecewicz, SM, Pandey, A, Roy, B, Xiang, S, Zetter, BR & Sengupta, S 2012, PLoS ONE, vol 7, no. 2, e32191. DOI:

Emerging technologies for enabling proangiogenic therapy
Roy, RS, Roy, B & Sengupta, S 2011, Nanotechnology, vol 22, no. 49, 494004. DOI:

Rationally engineered polymeric cisplatin nanoparticles for improved antitumor efficacy
Paraskar, A, Soni, S, Basu, S, Amarasiriwardena, CJ, Lupoli, N, Srivats, S, Roy, RS & Sengupta, S 2011, Nanotechnology, vol 22, no. 26, 265101. DOI: