Not found

Shiladitya Sengupta, PhD

Assistant Research Professor of Radiation Oncology, Institute for Academic Medicine
Assistant Research Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Biography

Dr. Sengupta is an Assistant Research Member in the department of Radiation Oncology of Houston Methodist Research Institute, and is also affiliated to Houston Methodist Institute for Academic Medicine and Weill Cornell Medical College, New York as Assistant Research Professor. Before joining Houston Methodist in September 2013, he was a Research Scientist at University of Texas Medical Branch at Galveston. He was a 2011-2013 Keck Fellow of Gulf Coast Consortia's Computational Cancer Biology Training Program, funded by the Cancer Prevention and Research Institute of Texas. He received PhD in 2008 from Jadavpur University, India, and is also a recipient of 2007 Young Scientist Award from Indian Institute of Human Genetics. He also serves as a regular reviewer for DNA Repair, Mutation Research, Oncotarget, DNA and Cell Biology, etc.  

Description of Research

Dr. Sengupta supervises fresh graduate and undergraduate students in the Mitra laboratory.

Areas Of Expertise

Cell proliferation Drug resistance Transcription regulation Protein acetylation Genome damage response Genomic instability
Education & Training

, Jadavpur University
, University of Calcutta
Publications

Human AP-endonuclease (APE1) is acetylated at DNA damage sites in chromatin and acetylation modulates its DNA repair activity
Roychoudhury, S, Nath, S, Song, H, Hegde, ML, Bellot, LJ, Mantha, AK, Sengupta, S, Ray, S, Natarajan, A & Bhakat, KK 2016, Molecular and Cellular Biology. DOI:

Microhomology-mediated end joining is activated in irradiated human cells due to phosphorylation-dependent formation of the XRCC1 repair complex
Dutta, A, Eckelmann, B, Adhikari, S, Ahmed, KM, Sengupta, S, Pandey, A, Hegde, PM, Tsai, M-S, Tainer, JA, Weinfeld, M, Hegde, ML & Mitra, S 2016, Nucleic acids research. DOI:

Dynamic Microenvironment Induces Phenotypic Plasticity of Esophageal Cancer Cells under Flow
Kocal, GC, Güven, S, Foygel, K, Goldman, A, Chen, P, Sengupta, S, Paulmurugan, R, Baskin, Y & Demirci, U 2016, Scientific Reports, vol 6, 38221. DOI:

Regulation of oxidized base damage repair by chromatin assembly factor 1 subunit A
Yang, C , Sengupta, S, Hegde, PM, Mitra, J, Jiang, S, Holey, B, Sarker, AH, Tsai, M-S, Hegde, ML & Mitra, S 2016, Nucleic acids research. DOI:

Combining Immune Checkpoint Inhibitors and Kinase-Inhibiting Supramolecular Therapeutics for Enhanced Anticancer Efficacy
Kulkarni, A, Natarajan, SK, Chandrasekar, V, Pandey, PR & Sengupta, S 2016, ACS Nano, vol 10, no. 10, pp. 9227-9242. DOI:

Combining Immune Checkpoint Inhibitors and Kinase-Inhibiting Supramolecular Therapeutics for Enhanced Anticancer Efficacy
Kulkarni, A, Natarajan, SK, Chandrasekar, V, Pandey, PR & Sengupta, S 2016, ACS Nano, vol 10, no. 10, pp. 9227-9242. DOI:

Sustained inhibition of cMET-VEGFR2 signaling using liposome-mediated delivery increases efficacy and reduces toxicity in kidney cancer
Kulkarni, AA, Vijaykumar, VE, Natarajan, SK, Sengupta, S & Sabbisetti, VS 2016, Nanomedicine: Nanotechnology, Biology, and Medicine, vol 12, no. 7, pp. 1853-1861. DOI:

Algorithm for Designing Nanoscale Supramolecular Therapeutics with Increased Anticancer Efficacy
Kulkarni, A, Pandey, P, Rao, P, Mahmoud, A, Goldman, A, Sabbisetti, V, Parcha, S, Natarajan, SK, Chandrasekar, V, Dinulescu, D, Roy, S & Sengupta, S 2016, ACS Nano, vol 10, no. 9, pp. 8154-8168. DOI:

Algorithm for Designing Nanoscale Supramolecular Therapeutics with Increased Anticancer Efficacy
Kulkarni, A, Pandey, P, Rao, P, Mahmoud, A, Goldman, A, Sabbisetti, V, Parcha, S, Natarajan, SK, Chandrasekar, V, Dinulescu, D, Roy, S & Sengupta, S 2016, ACS Nano, vol 10, no. 9, pp. 8154-8168. DOI:

Algorithm for Designing Nanoscale Supramolecular Therapeutics with Increased Anticancer Efficacy
Kulkarni, A, Pandey, P, Rao, P, Mahmoud, A, Goldman, A, Sabbisetti, V, Parcha, S, Natarajan, SK, Chandrasekar, V, Dinulescu, D, Roy, S & Sengupta, S 2016, ACS Nano, vol 10, no. 9, pp. 8154-8168. DOI:

Rationally Designed 2-in-1 Nanoparticles Can Overcome Adaptive Resistance in Cancer
Goldman, A, Kulkarni, A, Kohandel, M, Pandey, P, Rao, P, Natarajan, SK, Sabbisetti, V & Sengupta, S 2016, ACS Nano, vol 10, no. 6, pp. 5823-5834. DOI:

Drug-induced reactive oxygen species (ROS) rely on cell membrane properties to exert anticancer effects
Molavian, HR, Goldman, A, Phipps, CJ, Kohandel, M, Wouters, BG, Sengupta, S & Sivaloganathan, S 2016, Scientific Reports, vol 6, 27439. DOI:

Scaffold attachment factor A (SAF-A) and Ku temporally regulate repair of radiation-induced clustered genome lesions
Hegde, ML, Dutta, A, Yang, C, Mantha, AK, Hegde, PM, Pandey, A, Sengupta, S, Yu, Y, Calsou, P, Chen, D, Lees-Miller, SP & Mitra, S 2016, Oncotarget. DOI:

Notch-Jagged signalling can give rise to clusters of cells exhibiting a hybrid epithelial/mesenchymal phenotype
Boareto, M, Jolly, MK, Goldman, A, Pietilä, M, Mani, SA, Sengupta, S, Ben-Jacob, E, Levine, H & Onuchic, JN 2016, Journal of the Royal Society Interface, vol 13, no. 118, 20151106. DOI:

Reporter nanoparticle that monitors its anticancer efficacy in real time
Kulkarni, A, Rao, P, Natarajan, S, Goldman, A, Sabbisetti, VS, Khater, Y, Korimerla, N, Chandrasekar, V, Mashelkar, RA & Sengupta, S 2016, Proceedings of the National Academy of Sciences of the United States of America, vol 113, no. 15, pp. E2104-E2113. DOI:

Regulation of limited N-terminal proteolysis of APE1 in tumor via acetylation and its role in cell proliferation
Bhakat, KK, Sengupta, S, Adeniyi, VF, Roychoudhury, S, Nath, S, Bellot, LJ, Feng, D, Mantha, AK, Sinha, M, Qiu, S & Luxon, BA 2016, Oncotarget. DOI:

Physical nanoscale conduit-mediated communication between tumour cells and the endothelium modulates endothelial phenotype
Connor, Y, Tekleab, S, Nandakumar, S, Walls, C, Tekleab, Y, Husain, A, Gadish, O, Sabbisetti, V, Kaushik, S, Sehrawat, S, Kulkarni, A, Dvorak, H, Zetter, B, R. Edelman, E & Sengupta, S 2015, Nature Communications, vol 6, 8671. DOI:

Predicting clinical response to anticancer drugs using an ex vivo platform that captures tumour heterogeneity
Majumder, B, Baraneedharan, U, Thiyagarajan, S, Radhakrishnan, P, Narasimhan, H, Dhandapani, M, Brijwani, N, Pinto, DD, Prasath, A, Shanthappa, BU, Thayakumar, A, Surendran, R, Babu, GK, Shenoy, AM, Kuriakose, MA, Bergthold, G, Horowitz, P, Loda, M, Beroukhim, R, Agarwal, S, Sengupta, S, Sundaram, M & Majumder, PK 2015, Nature Communications, vol 6, 6169. DOI:

Temporally sequenced anticancer drugs overcome adaptive resistance by targeting a vulnerable chemotherapy-induced phenotypic transition
Goldman, A, Majumder, B, Dhawan, A, Ravi, S, Goldman, D, Kohandel, M, Majumder, PK & Sengupta, S 2015, Nature Communications, vol 6, 6139. DOI:

Anti-platelet agents augment cisplatin nanoparticle cytotoxicity by enhancing tumor vasculature permeability and drug delivery
Pandey, A, Sarangi, S, Chien, K, Sengupta, P, Papa, AL, Basu, S & Sengupta, S 2014, Nanotechnology, vol 25, no. 44, 445101. DOI: