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Scott Wesley Long, MD, PhD

Assistant Professor of Pathology and Genomic Medicine, Institute for Academic Medicine
Houston Methodist
Weill Cornell Medical College

Dr. Long received his MD degree in 2007 from The University of Texas Medical Branch (UTMB) in Galveston TX, where he also earned a PhD in Experimental Pathology. While at UTMB, he was the recipient of a McLaughlin Fellowship for Immunity and Infectious Disease and a Sealy Center for Vaccine Development fellowship. After finishing his doctoral studies, Dr. Long completed a clinical pathology residency at Houston Methodist. He currently serves as a member of the Editorial Board for Archives of Pathology and Laboratory Medicine. Dr. Long joined Houston Methodist Hospital in 2011, and received his faculty appointment at the Weill Cornell Medical College in 2012. 

Description of Research

Dr. Long’s research centers on functional genomics of multidrug-resistant bacterial strains to identify novel drug targets. He is currently focusing his work on MRSA (methicillin-resistant Staphylococcus aureus) and Klebsiella pneumoniae, both of which readily acquire resistance to several different types of antibiotics and are prevalent in the hospital setting.

Education & Training

, The Methodist Hospital
, University of Texas Medical Branch at Galveston

Comparative whole genome sequencing of community-associated methicillin-resistant Staphylococcus aureus sequence type 8 from primary care clinics in a Texas community
Lee, GC, Long, SW, Musser, JM, Beres, SB, Olsen, RJ, Dallas, SD, Nunez, YO & Frei, CR 2015, Pharmacotherapy, vol 35, no. 2, pp. 220-228. DOI:

Improving positive blood culture removal time significantly decreases total processing time
Salazar, E, Divatia, M, Cernoch, PL, Olsen, RJ, Long, SW, Land, GA, Davis, JR & Musser, JM 2015, Archives of Pathology and Laboratory Medicine, vol 139, no. 2, pp. 199-203. DOI:

The majority of 9,729 group A streptococcus strains causing disease secrete SpeB cysteine protease: Pathogenesis implications
Olsen, RJ, Raghuram, A, Cantu, C, Hartman, MH, Jimenez, FE, Lee, S, Ngo, A, Rice, KA, Saddington, D, Spillman, H, Valson, C, Flores, AR, Beres, SB, Wesley Long, S, Nasser, W & Musser, JM 2015, Infection and Immunity, vol 83, no. 12, pp. 4750-4758. DOI:

PBP2a mutations causing high-level ceftaroline resistance in clinical methicillin-resistant Staphylococcus aureus isolates
Long, SW , Olsen, RJ, Mehta, SC, Palzkill, T, Cernoch, PL, Perez, KK, Musick, WL, Rosato, AE & Musser, JM 2014, Antimicrobial Agents and Chemotherapy, vol 58, no. 11, pp. 6668-6674. DOI:

Absence of Patient-to-Patient intrahospital transmission of staphylococcus aureus as determined by Whole-Genome sequencing
Wesley Long, S , Beres, SB , Olsen, RJ & Musser, JM 2014, mBio, vol 5, no. 5, e01692-1. DOI:

Evolutionary pathway to increased virulence and epidemic group A Streptococcus disease derived from 3,615 genome sequences
Nasser, W, Beres, SB, Olsen, RJ, Dean, MA, Rice, KA, Long, SW, Kristinsson, KG, Gottfredsson, M, Vuopio, J, Raisanen, K, Caugant, DA, Steinbakk, M, Low, DE, McGeer, A, Darenberg, J, Henriques-Normark, B, Van Beneden, CA, Hoffmann, S & Musser, JM 2014, Proceedings of the National Academy of Sciences of the United States of America, vol 111, no. 17. DOI:

Clinical laboratory response to a mock outbreak of invasive bacterial infections: A preparedness study
Olsen, RJ, Fittipaldi, N, Kachroo, P, Sanson, MA, Long, SW, Como-Sabetti, KJ, Valson, C, Cantu, C, Lynfield, R, Van Beneden, C, Beres, SB & Musser, JM 2014, Journal of Clinical Microbiology, vol 52, no. 12, pp. 4210-4216. DOI:

Identification of point mutations in clinical staphylococcus aureus strains that produce small-colony variants auxotrophic for menadione
Dean, MA, Olsen, RJ, Wesley Long, S, Rosato, AE & Musser, JM 2014, Infection and Immunity, vol 82, no. 4, pp. 1600-1605. DOI:

A genomic day in the life of a clinical microbiology laboratory
Long, SW, Williams, D, Valson, C, Cantu, CC, Cernoch, P, Musser, JM & Olsen, RJ 2013, Journal of Clinical Microbiology, vol 51, no. 4, pp. 1272-1277. DOI:

Bacterial genomics in infectious disease and the clinical pathology laboratory
Olsen, RJ , Long, SW & Musser, JM 2012, Archives of Pathology and Laboratory Medicine, vol 136, no. 11, pp. 1414-1422. DOI:

Strategy for rapid identification and antibiotic susceptibility testing of gram-negative bacteria directly recovered from positive blood cultures using the Bruker MALDI biotyper and the BD phoenix system
Wimmer, JL, Long, SW, Cernoch, P, Land, GA, Davis, JR, Musser, JM & Olsen, RJ 2012, Journal of Clinical Microbiology, vol 50, no. 7, pp. 2452-2454. DOI:

Rapidly progressive, fatal, inhalation anthrax-like infection in a human: Case report, pathogen genome sequencing, pathology, and coordinated response
Wright, AM, Beres, SB, Consamus, EN, Long, SW, Flores, AR, Barrios, R, Richter, GS, Oh, SY, Garufi, G, Maier, H, Drews, AL, Stockbauer, KE, Cernoch, P, Schneewind, O, Olsen, RJ & Musser, JM 2011, Archives of Pathology and Laboratory Medicine, vol 135, no. 11, pp. 1447-1459. DOI:

A preliminary investigation of Ehrlichia species in ticks, humans, dogs, and capybaras from Brazil
Labruna, MB, McBride, JW, Camargo, LMA, Aguiar, DM, Yabsley, MJ, Davidson, WR, Stromdahl, EY, Williamson, PC, Stich, RW, Long, SW, Camargo, EP & Walker, DH 2007, Veterinary Parasitology, vol 143, no. 2, pp. 189-195. DOI:

Overcoming barriers to the transformation of the genus Ehrlichia.
Long, SW, Whitworth, TJ, Walker, DH & Yu, XJ 2005, Annals of the New York Academy of Sciences, vol 1063, pp. 403-410. DOI:

Ehrlichia prevalence in Amblyomma americanum, Central Texas [11]
Long, SW, Pound, JM & Yu, XJ 2004, Emerging Infectious Diseases, vol 10, no. 7, pp. 1342-1343.

Evaluation of Transovarial Transmission and Transmissibility of Ehrlichia chaffeensis (Rickettsiales: Anaplasmataceae) in Amblyomma americanum (Acari: Ixodidae)
Long, SW, Zhang, X, Zhang, J, Ruble, RP, Teel, P & Yu, XJ 2003, Journal of Medical Entomology, vol 40, no. 6, pp. 1000-1004.

Experimental Ehrlichia chaffeensis infection in beagles
Zhang, XF, Zhang, JZ, Long, SW, Ruble, RP & Yu, XJ 2003, Journal of Medical Microbiology, vol 52, no. 11, pp. 1021-1026. DOI:

Antigenic variation of Ehrlichia chaffeensis resulting from differential expression of the 28-kilodalton protein gene family
Long, SW, Zhang, XF, Qi, H, Standaert, S, Walker, DH & Yu, XJ 2002, Infection and Immunity, vol 70, no. 4, pp. 1824-1831. DOI: