Roberto Barrios, MD

Professor of Pathology and Genomic Medicine, Institute for Academic Medicine
Full Clinical Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Dr. Barrios received his first academic appointment at the Universidad Nacional Autonoma de Mexico as Assistant Professor of Histology and Pathology in the Department of Chemistry in 1978. In 1982, he was promoted to full Professor in the Department of Cell Biology, and elected Head of the Department of Electron Microscopy at the same institution. He then became Chairman of the Department of Pathology at the Mexican Cardiology Institute and later Chairman of Pathology at the National Institute for Respiratory Diseases in Mexico City. He was visiting professor from 1990 through 1992 in Dr. Michael Lieberman’s laboratory at Baylor College of Medicine, conducting molecular biology studies. In 1992, Dr. Barrios was appointed Associate Professor in the Department of Pathology at Baylor College of Medicine, where he led numerous conferences and lectures for medical students. In 2004, he assumed his positions at Houston Methodist Hospital as Professor of Pathology and Laboratory Medicine at Weill Cornell Medical College.

Description of Research

Dr. Barrios has worked with experimental pathology projects for the last twenty-eight years, while at the same time his primary area of interest in diagnostic pathology has been pulmonary and renal pathology. His current projects include the study of interstitial lung diseases and pulmonary neoplasms. His collaborations in experimental pathology are related to oncogenesis and oxygen toxicity.



Areas Of Expertise

Pulmonary Renal Pathology
Education & Training

Clinical Fellowship, McGill University
Residency, Case Western Reserve University
MD, Facultad De Medicina - Instituto Tech.

Hypersensitivity pneumonitis: A perspective from members of the pulmonary pathology society
Miller, R, Allen, TC, Barrios, RJ, Beasley, MB, Burke, L, Cagle, PT, Capelozzi, VL, Ge, Y, Hariri, LP, Kerr, KM, Khoor, A, Larsen, BT, Mark, EJ, Matsubara, O, Mehrad, M, Mino-Kenudson, M, Raparia, K, Roden, AC, Russell, P, Schneider, F, Sholl, LM & Smith, ML 2018, Archives of Pathology and Laboratory Medicine, vol 142, no. 1, pp. 120-126. DOI: 10.5858/arpa.2017-0138-SA

Long-term pulmonary and cardiovascular morbidities of neonatal hyperoxia exposure in mice
Menon, RT, Shrestha, AK, Reynolds, CL, Barrios, R & Shivanna, B 2018, International Journal of Biochemistry and Cell Biology, vol 94, pp. 119-124. DOI: 10.1016/j.biocel.2017.12.001

Programmed death ligand-1 (pd-l1) expression in either tumor cells or tumor-infiltrating immune cells correlates with solid and high-grade lung adenocarcinomas
Driver, BR, Miller, RA, Miller, T, Deavers, M, Gorman, B, Mody, D, Ge, Y, Barrios, R, Bernicker, E, Kim, M & Cagle, PT 2017, Archives of Pathology and Laboratory Medicine, vol 141, no. 11, pp. 1529-1532. DOI: 10.5858/arpa.2017-0028-OA

Involvement of the Bufadienolides in the Detection and Therapy of the Acute Respiratory Distress Syndrome
Abbas, MMK, Patel, B, Chen, Q, Jiang, W, Moorthy, B, Barrios, R & Puschett, JB 2017, Lung, vol 195, no. 3, pp. 323-332. DOI: 10.1007/s00408-017-9989-1

Newborn mice lacking the gene for Cyp1a1 are more susceptible to oxygen-mediated lung injury, and are rescued by postnatal b-naphthoflavone administration: Implications for bronchopulmonary dysplasia in premature infants
Maturu, P, Wei-Liang, Y, Jiang, W, Wang, L, Lingappan, K, Barrios, R, Liang, Y, Moorthy, B & Couroucli, XI 2017, Toxicological Sciences, vol 157, no. 1, pp. 260-271. DOI: 10.1093/toxsci/kfx036

Hypertrophic Cardiomyopathy with Unusual Extensive Scarring Pattern: Danon Disease
Le, D, Alvarez, P, Barrios, R, Arriaga, M, Cherry, M, Shah, D & Lin, CH 2017, Methodist DeBakey cardiovascular journal, vol 12, no. 4, pp. 227-229. DOI: 10.14797/mdcj-12-4-227

Diagnosis of Acute Cellular Rejection and Antibody-Mediated Rejection on Lung Transplant Biopsies: A Perspective From Members of the Pulmonary Pathology Society
Roden, AC, Aisner, DL, Allen, TC, Aubry, MC, Barrios, RJ, Beasley, MB, Cagle, PT, Capelozzi, VL, Dacic, S, Ge, Y, Hariri, LP, Lantuejoul, S, Miller, RA, Mino-Kenudson, M, Moreira, AL, Raparia, K, Rekhtman, N, Sholl, L, Smith, ML, Tsao, MS, Vivero, M, Yatabe, Y & Yi, ES 2016, Archives of Pathology and Laboratory Medicine. DOI: 10.5858/arpa.2016-0459-SA

Phenotypic assessment of pulmonary hypertension using high-resolution echocardiography is feasible in neonatal mice with experimental bronchopulmonary dysplasia and pulmonary hypertension: A step toward preventing chronic obstructive pulmonary disease
Reynolds, CL, Zhang, S, Shrestha, AK, Barrios, R & Shivanna, B 2016, International journal of chronic obstructive pulmonary disease, vol 11, no. 1, pp. 1597-1605. DOI: 10.2147/COPD.S109510

Folate Receptor a Expression Level Correlates With Histologic Grade in Lung Adenocarcinoma
Driver, BR, Barrios, R, Ge, Y, Haque, A, Tacha, D & Cagle, PT 2016, Archives of Pathology and Laboratory Medicine, vol 140, no. 7, pp. 682-685. DOI: 10.5858/arpa.2015-0431-OA

Impact of recent developments in lung cancer on the practice of pathology
Cagle, PT, Allen, TC, Bernicker, EH, Ge, Y, Haque, A & Barrios, R 2016, Archives of Pathology and Laboratory Medicine, vol 140, no. 4, pp. 322-325. DOI: 10.5858/arpa.2015-0535-SA

Intravascular carcinomatosis of central nervous system due to metastatic inflammatory breast cancer: A case report
Takei, H, Rouah, E & Barrios, R 2015, Neuropathology, vol 35, no. 5, pp. 456-461. DOI: 10.1111/neup.12206

Disruption of cytochrome P4501A2 in mice leads to increased susceptibility to hyperoxic lung injury
Wang, L, Lingappan, K, Jiang, W, Couroucli, XI, Welty, SE, Shivanna, B, Barrios, R, Wang, G, Firoze Khan, M, Gonzalez, FJ, Jackson Roberts, L & Moorthy, B 2015, Free Radical Biology and Medicine, vol 82, pp. 147-159. DOI: 10.1016/j.freeradbiomed.2015.01.019

Increased susceptibility to hyperoxic lung injury and alveolar simplification in newborn rats by prenatal administration of benzo[a]pyrene
Thakur, VS, Liang, YW, Lingappan, K, Jiang, W, Wang, L, Barrios, R, Zhou, G, Guntupalli, B, Shivanna, B, Maturu, P, Welty, SE, Moorthy, B & Couroucli, XI 2014, Toxicology Letters, vol 230, no. 2, pp. 322-332. DOI: 10.1016/j.toxlet.2014.03.006

Double lung transplantation for diffuse idiopathic pulmonary neuroendocrine cell hyperplasia
Zhou, H, Ge, Y, Janssen, B, Peterson, A, Takei, H, Haque, A, Barrios, R & Cagle, P 2014, Journal of Bronchology and Interventional Pulmonology, vol 21, no. 4, pp. 342-345.

Magnetically guided recellularization of decellularized stented porcine pericardium-derived aortic valve for TAVI
Ghodsizad, A, Bordel, V, Wiedensohler, H, Elbanayosy, A, Koerner, MMA, Gonzalez Berjon, JM, Barrios, R, Farag, M, Zeriouh, M, Loebe, M, Noon, GPE, Koegler, G, Karck, M & Ruhparwar, A 2014, ASAIO Journal, vol 60, no. 5, pp. 582-586. DOI: 10.1097/MAT.0000000000000110

High proportion of patients with end-stage heart failure regardless of aetiology demonstrates anti-cardiac antibody deposition in failing myocardium: Humoral activation, a potential contributor of disease progression
Youker, KA, Assad-Kottner, C, Cordero-Reyes, AM, Trevino, AR, Flores-Arredondo, JH, Barrios, R, Fernandez-Sada, E, Estep, JD, Bhimaraj, A & Torre-Amione, G 2014, European Heart Journal, vol 35, no. 16, pp. 1061-1068. DOI: 10.1093/eurheartj/eht506

Mice deficient in the gene for cytochrome P450 (CYP)1A1 are more susceptible than wild-type to hyperoxic lung injury: Evidence for protective role of CYP1A1 against oxidative stress
Lingappan, K, Jiang, W, Wang, L, Wang, G, Couroucli, XI, Shivanna, B, Welty, SE, Barrios, R, Khan, MF, Nebert, DW, Roberts, LJ & Moorthy, B 2014, Toxicological Sciences, vol 141, no. 1, kfu106, pp. 68-77. DOI: 10.1093/toxsci/kfu106

The presence of anti-HLA donor-specific antibodies in lung allograft recipients does not correlate with C4d immunofluorescence in transbronchial biopsy specimens
Roberts, JA, Barrios, R, Cagle, PT, Ge, Y, Takei, H, Haque, AK, Burns, KM, Land, GA, Dilioglou, S & Bernard, DW 2014, Archives of Pathology and Laboratory Medicine, vol 138, no. 8, pp. 1053-1058. DOI: 10.5858/arpa.2013-0539-OA

Sex-specific differences in hyperoxic lung injury in mice: Implications for acute and chronic lung disease in humans
Lingappan, K, Jiang, W, Wang, L, Couroucli, XI, Barrios, R & Moorthy, B 2013, Toxicology and Applied Pharmacology, vol 272, no. 2, pp. 281-290. DOI: 10.1016/j.taap.2013.06.007

Cytogenomics and gene expression in a case of metachronous bilateral renal cell carcinomas with drop metastasis: Resolving a diagnostic dilemma with molecular technologies
Takei, H , Barrios, R & Monzon, FA 2013, Pathology International, vol 63, no. 6, pp. 326-332. DOI: 10.1111/pin.12068