Roberto Barrios, MD

Professor of Pathology and Genomic Medicine, Institute for Academic Medicine
Full Clinical Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Biography

Dr. Barrios received his first academic appointment at the Universidad Nacional Autonoma de Mexico as Assistant Professor of Histology and Pathology in the Department of Chemistry in 1978. In 1982, he was promoted to full Professor in the Department of Cell Biology, and elected Head of the Department of Electron Microscopy at the same institution. He then became Chairman of the Department of Pathology at the Mexican Cardiology Institute and later Chairman of Pathology at the National Institute for Respiratory Diseases in Mexico City. He was visiting professor from 1990 through 1992 in Dr. Michael Lieberman’s laboratory at Baylor College of Medicine, conducting molecular biology studies. In 1992, Dr. Barrios was appointed Associate Professor in the Department of Pathology at Baylor College of Medicine, where he led numerous conferences and lectures for medical students. In 2004, he assumed his positions at Houston Methodist Hospital as Professor of Pathology and Laboratory Medicine at Weill Cornell Medical College.

Description of Research

Dr. Barrios has worked with experimental pathology projects for the last twenty-eight years, while at the same time his primary area of interest in diagnostic pathology has been pulmonary and renal pathology. His current projects include the study of interstitial lung diseases and pulmonary neoplasms. His collaborations in experimental pathology are related to oncogenesis and oxygen toxicity.

 

 

Areas Of Expertise

Pulmonary Renal Pathology
Education & Training

Clinical Fellowship , McGill University
Residency , Case Western Reserve University
MD , Facultad De Medicina - Instituto Tech.
Publications

Diagnosis of Acute Cellular Rejection and Antibody-Mediated Rejection on Lung Transplant Biopsies: A Perspective From Members of the Pulmonary Pathology Society
Roden, AC, Aisner, DL, Allen, TC, Aubry, MC, Barrios, RJ, Beasley, MB, Cagle, PT, Capelozzi, VL, Dacic, S, Ge, Y, Hariri, LP, Lantuejoul, S, Miller, RA, Mino-Kenudson, M, Moreira, AL, Raparia, K, Rekhtman, N, Sholl, L, Smith, ML, Tsao, MS, Vivero, M, Yatabe, Y & Yi, ES 2016, Archives of Pathology and Laboratory Medicine. DOI:

Phenotypic assessment of pulmonary hypertension using high-resolution echocardiography is feasible in neonatal mice with experimental bronchopulmonary dysplasia and pulmonary hypertension: A step toward preventing chronic obstructive pulmonary disease
Reynolds, CL, Zhang, S, Shrestha, AK, Barrios, R & Shivanna, B 2016, International journal of chronic obstructive pulmonary disease, vol 11, no. 1, pp. 1597-1605. DOI:

Folate Receptor a Expression Level Correlates With Histologic Grade in Lung Adenocarcinoma
Driver, BR, Barrios, R, Ge, Y, Haque, A, Tacha, D & Cagle, PT 2016, Archives of Pathology and Laboratory Medicine, vol 140, no. 7, pp. 682-685. DOI:

Impact of recent developments in lung cancer on the practice of pathology
Cagle, PT, Allen, TC, Bernicker, EH, Ge, Y, Haque, A & Barrios, R 2016, Archives of Pathology and Laboratory Medicine, vol 140, no. 4, pp. 322-325. DOI:

Intravascular carcinomatosis of central nervous system due to metastatic inflammatory breast cancer: A case report
Takei, H, Rouah, E & Barrios, R 2015, Neuropathology, vol 35, no. 5, pp. 456-461. DOI:

Disruption of cytochrome P4501A2 in mice leads to increased susceptibility to hyperoxic lung injury
Wang, L, Lingappan, K, Jiang, W, Couroucli, XI, Welty, SE, Shivanna, B, Barrios, R, Wang, G, Firoze Khan, M, Gonzalez, FJ, Jackson Roberts, L & Moorthy, B 2015, Free Radical Biology and Medicine, vol 82, pp. 147-159. DOI:

Increased susceptibility to hyperoxic lung injury and alveolar simplification in newborn rats by prenatal administration of benzo[a]pyrene
Thakur, VS, Liang, YW, Lingappan, K, Jiang, W, Wang, L, Barrios, R, Zhou, G, Guntupalli, B, Shivanna, B, Maturu, P, Welty, SE, Moorthy, B & Couroucli, XI 2014, Toxicology Letters, vol 230, no. 2, pp. 322-332. DOI:

Double lung transplantation for diffuse idiopathic pulmonary neuroendocrine cell hyperplasia
Zhou, H, Ge, Y, Janssen, B, Peterson, A, Takei, H, Haque, A, Barrios, R & Cagle, P 2014, Journal of Bronchology and Interventional Pulmonology, vol 21, no. 4, pp. 342-345.

Magnetically guided recellularization of decellularized stented porcine pericardium-derived aortic valve for TAVI
Ghodsizad, A, Bordel, V, Wiedensohler, H, Elbanayosy, A, Koerner, MMA, Gonzalez Berjon, JM, Barrios, R, Farag, M, Zeriouh, M, Loebe, M, Noon, GPE, Koegler, G, Karck, M & Ruhparwar, A 2014, ASAIO Journal, vol 60, no. 5, pp. 582-586. DOI:

High proportion of patients with end-stage heart failure regardless of aetiology demonstrates anti-cardiac antibody deposition in failing myocardium: Humoral activation, a potential contributor of disease progression
Youker, KA, Assad-Kottner, C, Cordero-Reyes, AM, Trevino, AR, Flores-Arredondo, JH, Barrios, R, Fernandez-Sada, E, Estep, JD, Bhimaraj, A & Torre-Amione, G 2014, European Heart Journal, vol 35, no. 16, pp. 1061-1068. DOI:

Mice deficient in the gene for cytochrome P450 (CYP)1A1 are more susceptible than wild-type to hyperoxic lung injury: Evidence for protective role of CYP1A1 against oxidative stress
Lingappan, K, Jiang, W, Wang, L, Wang, G, Couroucli, XI, Shivanna, B, Welty, SE, Barrios, R, Khan, MF, Nebert, DW, Roberts, LJ & Moorthy, B 2014, Toxicological Sciences, vol 141, no. 1, kfu106, pp. 68-77. DOI:

The presence of anti-HLA donor-specific antibodies in lung allograft recipients does not correlate with C4d immunofluorescence in transbronchial biopsy specimens
Roberts, JA, Barrios, R, Cagle, PT, Ge, Y, Takei, H, Haque, AK, Burns, KM, Land, GA, Dilioglou, S & Bernard, DW 2014, Archives of Pathology and Laboratory Medicine, vol 138, no. 8, pp. 1053-1058. DOI:

Sex-specific differences in hyperoxic lung injury in mice: Implications for acute and chronic lung disease in humans
Lingappan, K, Jiang, W, Wang, L, Couroucli, XI, Barrios, R & Moorthy, B 2013, Toxicology and Applied Pharmacology, vol 272, no. 2, pp. 281-290. DOI:

Cytogenomics and gene expression in a case of metachronous bilateral renal cell carcinomas with drop metastasis: Resolving a diagnostic dilemma with molecular technologies
Takei, H , Barrios, R & Monzon, FA 2013, Pathology International, vol 63, no. 6, pp. 326-332. DOI:

Preface
Barrios, R & Haque, AK 2013, . in Parasitic Diseases of the Lungs. Springer Berlin Heidelberg, pp. v. DOI:

Parasitic diseases of the lungs
Barrios, R & Haque, AK (eds) 2013, . Springer Berlin Heidelberg. DOI:

Portal application of human unrestricted somatic stem cells to support hepatic regeneration after portal embolization and tumor surgery
Ghodsizad, A, Fahy, BN, Waclawczyk, S, Liedtke, S, Gonzalez Berjon, JM, Barrios, R, Mehrabi, A, Karck, M, Ruhparwar, A & Kögler, G 2012, ASAIO Journal, vol 58, no. 3, pp. 255-261. DOI:

Rapidly progressive, fatal, inhalation anthrax-like infection in a human: Case report, pathogen genome sequencing, pathology, and coordinated response
Wright, AM, Beres, SB, Consamus, EN, Long, SW, Flores, AR, Barrios, R, Richter, GS, Oh, SY, Garufi, G, Maier, H, Drews, AL, Stockbauer, KE, Cernoch, P, Schneewind, O, Olsen, RJ & Musser, JM 2011, Archives of Pathology and Laboratory Medicine, vol 135, no. 11, pp. 1447-1459. DOI:

Prenatal administration of the cytochrome P4501A inducer, ?-naphthoflavone (BNF), attenuates hyperoxic lung injury in newborn mice: Implications for bronchopulmonary dysplasia (BPD) in premature infants
Couroucli, XI, Liang, YHW, Jiang, W, Wang, L, Barrios, R, Yang, P & Moorthy, B 2011, Toxicology and Applied Pharmacology, vol 256, no. 2, pp. 83-94. DOI:

Augmented oxygen-mediated transcriptional activation of cytochrome P450 (CYP)1A expression and increased susceptibilities to hyperoxic lung injury in transgenic mice carrying the human CYP1A1 or mouse 1A2 promoter in vivo
Jiang, W, Couroucli, XI, Wang, L, Barrios, R & Moorthy, B 2011, Biochemical and Biophysical Research Communications, vol 407, no. 1, pp. 79-85. DOI: