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Randa El-Zein, MBChB, PhD

Professor of Radiology, Institute for Academic Medicine
Full Member, Research Institute
Houston Methodist


rel-zein2@houstonmethodist.org
Biography

Dr. El-Zein earned her Medical Degree followed by a Masters in Human Genetics from the University of Alexandria. She then completed her Doctoral degree in Human Biological Chemistry and Genetics at the University of Texas Medical Branch with a focus on cancer genetics. In 1997, she joined the University of Texas MD Anderson Cancer Center as a postdoctoral fellow and rose through the ranks to Associate Professor in the Department of Epidemiology. In 2015, Dr. El-Zein joined Houston Methodist as a Professor in the Department of Radiology and a full member of the Research Institute.

Dr. El-Zein is an active member of the national and international scientific community. She serves/served as a reviewer for the National Institute of Health, National Lung, Heart and Blood Institute and the American Cancer Society. Internationally, she is a grant reviewer for the Italian Ministry of Health. Dr. El-Zein also serves as a peer reviewer for several high impact journals.

 

Description of Research

Dr. El-Zein’s research focus is on understanding the role of gene-environment interactions in the risk of cancer development. She has developed expertise in the area of biomarkers and genetic susceptibility to disease. She has applied unique markers to identify several inherited genetic traits that influence human sensitivity to different cancers such as lung, breast and lymphomas. Dr. El-Zein’s laboratory has a translational research approach, and is currently studying human populations using quantitative imaging coupled with molecular biomarkers to identify unique signatures that would improve the power of cancer risk assessment models. The results from these studies are providing new information that has significant and practical public health implications in the area of early detection and primary prevention of disease. The overall goal is to develop novel approaches to identify susceptible individuals at high risk of developing lung and breast cancers. New knowledge generated from these research endeavors are geared to fulfill the need for rapid and efficient translation of emerging new technologies and approaches for improved patient management, early detection and prevention.Dr. El-Zein’s research focus is on understanding the role of gene-environment interactions in the risk of cancer development. She has developed expertise in the area of genotypic and phenotypic biomarkers and genetic susceptibility to disease. She has applied these unique markers to identify several inherited genetic traits that influence human sensitivity to different cancers such as lung, breast and lymphomas. Dr. El-Zein’s laboratory has a translational research approach, and is currently studying human populations using quantitative imaging coupled with molecular biomarkers to identify unique signatures that would improve the power of cancer risk assessment models. The results from these studies are providing new information that has significant and practical public health implications in the area of early detection and primary prevention of disease. The overall goal is to develop novel approaches to identify susceptible individuals at high risk of developing lung and breast cancers. New knowledge generated from these research endeavors are geared to fulfill the need for rapid and efficient translation of emerging new technologies and approaches for improved patient management, early detection and prevention.

Areas Of Expertise

Lung Cancer Breast Cancer Genetic Instability Genetic Susceptibility
Education & Training

MBBCh , Alexandria University
MS , Alexandria University
Postdoctoral Fellowship , The University of Texas MD Anderson Cancer Center
PhD , The University of Texas Medical Branch
Publications

Genomic landscape established by allelic imbalance in the cancerization field of a normal appearing airway
Jakubek, Y, Lang, W, Vattathil, S, Garcia, M, Xu, L, Huang, L, Yoo, SY, Shen, L, Lu, W, Chow, CW, Weber, Z, Davies, G, Huang, J, Behrens, C, Kalhor, N, Moran, C, Fujimoto, J, Mehran, R, El-Zein, R, Swisher, SG, Wang, J, Fowler, J, Spira, AE, Ehli, EA, Wistuba, II, Scheet, P & Kadara, H 2016, Cancer Research, vol 76, no. 13, pp. 3676-3683. DOI:

Epidemiological risk factors associated with inflammatory breast cancer subtypes
Atkinson, RL, El-Zein, R, Valero, V, Lucci, A, Bevers, TB, Fouad, T, Liao, W, Ueno, NT, Woodward, WA & Brewster, AM 2016, Cancer Causes and Control, vol 27, no. 3, pp. 359-366. DOI:

Identification of Small and Non-small Cell Lung Cancers Markers in Peripheral Blood using Cytokinesis-Blocked Micronucleus and Spectral Karyotyping Assays
El-Zein, RA, McHugh, MK, Shete, S & Yu, RK 2016, Biomarkers.

Chronic obstructive pulmonary disease among lung cancer free smokers: The importance of health controls
El-Zein, RA, McHugh, MK, R, E, Follis, JL, Etzel, CJ & Shete, S 2016, Respiratory Medicine.

Autophagy Inhibition to Increase Radiosensitization in Breast Cancer
Liang, DH, El-Zein, R & Dave, B 2015, Journal of nuclear medicine & radiation therapy, vol 6, no. 5. DOI:

Erratum: Overall survival differences between patients with inflammatory and noninflammatory breast cancer presenting with distant metastasis at diagnosis [Breast Cancer Res Treat, DOI 10.1007/s10549-015-3436-x]
Fouad, TM, Kogawa, T, Liu, DD, Shen, Y, Masuda, H, El-Zein, R, Woodward, WA, Chavez-MacGregor, M, Alvarez, RH, Arun, B, Lucci, A, Krishnamurthy, S, Babiera, G, Buchholz, TA, Valero, V & Ueno, NT 2015, Breast Cancer Research and Treatment, vol 152, no. 2, pp. 417. DOI:

Overall survival differences between patients with inflammatory and noninflammatory breast cancer presenting with distant metastasis at diagnosis
Fouad, TM, Kogawa, T, Liu, DD, Shen, Y, Masuda, H, El-Zein, R, Woodward, WA, Chavez-MacGregor, M, Alvarez, RH, Arun, B, Lucci, A, Krishnamurthy, S, Babiera, G, Buchholz, TA, Valero, V & Ueno, NT 2015, Breast Cancer Research and Treatment, vol 152, no. 2, pp. 407-416. DOI:

Association of body mass index changes during neoadjuvant chemotherapy with pathologic complete response and clinical outcomes in patients with locally advanced breast cancer
Kogawa, T, Fouad, TM, Wei, C, Masuda, H, Kai, K, Fujii, T, El-Zein, R, Chavez-MacGregor, M, Litton, JK, Brewster, A, Alvarez, RH, Hortobagyi, GN, Valero, V, Theriault, R & Ueno, NT 2015, Journal of Cancer, vol 6, no. 4, pp. 310-318. DOI:

Tumor endothelial markers define novel subsets of cancer-specific circulating endothelial cells associated with antitumor efficacy
Mehran, R, Nilsson, M, Khajavi, M, Du, Z, Cascone, T, Wu, HK, Cortes, A, Xu, L, Zurita, A, Schier, R, Riedel, B, El-Zein, R & Heymach, JV 2014, Cancer Research, vol 74, no. 10, pp. 2731-2741. DOI:

Endothelial progenitor cell mobilization by preoperative exercise: a bone marrow response associated with postoperative outcome.
Schier, R, El-Zein, R, Cortes, A, Liu, M, Collins, M, Rafat, N, Teschendorf, P, Wu, HK, Heymach, J, Mehran, R & Riedel, B 2014, British Journal of Anaesthesia, vol 113, no. 4, pp. 652-660. DOI:

Risk factors for inflammatory breast cancer and other invasive breast cancers: Schairer C, Li Y, Frawley P, et al (Univ of Maryland, College Park; Group Health Cooperative, Seattle, WA; Natl Insts of Health, Bethesda, MD; Et al) J Natl Cancer Inst 105:1373-1384, 2013
Fouad, TM, El-Zein, R & Ueno, NT 2014, Breast Diseases, vol 25, no. 2, pp. 124-125. DOI:

The cytokinesis-blocked micronucleus assay as a strong predictor of lung cancer: Extension of a lung cancer risk prediction model
El-Zein, RA, Lopez, MS, DAmelio, AM, Liu, M, Munden, RF, Christiani, D, Su, L, Tejera-Alveraz, P, Zhai, R, Spitz, MR & Etzel, CJ 2014, Cancer Epidemiology Biomarkers and Prevention, vol 23, no. 11, pp. 2462-2470. DOI:

Insulin-Like Growth Factor Binding Protein-2 Level Is Increased in Blood of Lung Cancer Patients and Associated with Poor Survival
Guo, C, Lu, H, Gao, W, Wang, L, Lu, K, Wu, S, Pataer, A, Huang, M, El-Zein, R, Lin, T, Roth, JA, Mehran, R, Hofstetter, W, Swisher, SG, Wu, X & Fang, B 2013, PLoS ONE, vol 8, no. 9, e74973. DOI:

Bridging the clinical gaps: Genetic, epigenetic and transcriptomic biomarkers for the early detection of lung cancer in the post-National Lung Screening Trial era
Brothers, JF, Hijazi, K, Mascaux, C, El-Zein, RA, Spitz, MR & Spira, A 2013, BMC Medicine, vol 11, no. 1, 168. DOI:

Cytokinesis-blocked micronucleus cytome assay and spectral karyotyping as methods for identifying chromosome damage in a lung cancer case-control population
Lloyd, SM, Lopez, M & El-Zein, R 2013, Genes Chromosomes and Cancer, vol 52, no. 7, pp. 694-707. DOI:

Genomic and expression analysis of microdissected inflammatory breast cancer
Woodward, WA, Krishnamurthy, S, Yamauchi, H, El-Zein, R, Ogura, D, Kitadai, E, Niwa, SI, Cristofanilli, M, Vermeulen, P, Dirix, L, Viens, P, Van Laere, S, Bertucci, F, Reuben, JM & Ueno, NT 2013, Breast Cancer Research and Treatment, vol 138, no. 3, pp. 761-772. DOI:

Evaluation of digital thermal monitoring as a tool to assess perioperative vascular reactivity
Schier, R, Marcus, HE, Mansur, E, Lei, X, El-Zein, R, Mehran, R, Purugganan, R, Heir, JS, Riedel, B & Gottumukkala, V 2013, Journal of Atherosclerosis and Thrombosis, vol 20, no. 3, pp. 277-286. DOI:

A novel technique for the assessment of preoperative cardiovascular risk: Reactive hyperemic response to short-term exercise
Schier, R, Hinkelbein, J, Marcus, H, Smallwood, A, Correa, AM, Mehran, R, El-Zein, R & Riedel, B 2013, BioMed Research International, vol 2013, 837130. DOI:

Status of the anaplastic lymphoma kinase (ALK) gene in inflammatory breast carcinoma
Krishnamurthy, S, Woodward, W, Yang, W, Reuben, JM, Tepperberg, J, Ogura, D, Niwa, SI, Huo, L, Gong, Y, El-Zein, R, Gonzalez-Angulo, AM, Gregor, MCM, Alvarez, R, Lucci, A, Valero, V & Ueno, NT 2013, SpringerPlus, vol 2, no. 1, pp. 1-7. DOI:

Use of the cytokinesis-blocked micronucleus assay to detect gender differences and genetic instability in a lung cancer case - Control study
McHugh, MK, Lopez, MS, Ho, CH, Spitz, MR, Etzel, CJ & El-Zein, RA 2013, Cancer Epidemiology Biomarkers and Prevention, vol 22, no. 1, pp. 135-145. DOI: