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Paul Rees, PhD

Full Affiliate Member, Research Institute
Houston Methodist


Paul Rees received his Ph.D. in physics from Cardiff University. He calculated the optical properties of semiconductor lasers and the measured spontaneous emissions from laser diodes under operating conditions. He was a research fellow in the physics department at Trinity College, Dublin, Ireland, where he studied self-pulsation in laser diodes and the theory of many-body effects in wide band-gap semiconductors. He later joined the School of Informatics, University of Wales, Bangor, UK, where he was appointed senior lecturer.

In 2005, Dr. Rees was appointed as the chair of nanotechnology in the newly-formed Multidisciplinary Nanotechnology Centre at Swansea University. As an Full Affiliate Member of Houston Methodist Research Institute, Dr. Rees collaborates with the nanomedicine department to study the uptake of micro and nanoparticles by biological cells. Dr. Rees also participates as a mentor for the graduate exchange training program between the Houston Methodist Academy and Swansea University.

Description of Research

Dr. Rees’ research focuses on the uptake of micro and nanoparticles by biological cells using high throughput imaging techniques such as imaging flow cytometry and multi-field imaging microscopy, the biological process of particle uptake, and the study of dose responses for drug molecules deliv-ered by particulate delivery vectors.

Areas Of Expertise

Laser diodes Nonlinear systems and chaos Simulation of cell mitosis Colloidal quantum dot fluorophores
Education & Training

, Cardiff University
, Trinity College Dublin

Generation of an in vitro 3D PDAC stroma rich spheroid model
Ware, MJ, Keshishian, V, Law, JJ, Ho, JC, Favela, CA, Rees, P, Smith, B, Mohammad, S, Hwang, RF, Rajapakshe, K, Coarfa, C, Huang, S, Edwards, DP, Corr, SJ, Godin, B & Curley, SA 2016, Biomaterials, vol 108, pp. 129-142. DOI:

Multiscale benchmarking of drug delivery vectors
Summers, HD, Ware, MJ, Majithia, R, Meissner, KE, Godin, B & Rees, P 2016, Nanomedicine: Nanotechnology, Biology, and Medicine, vol 12, no. 7, pp. 1843-1851. DOI:

An Analysis of the Practicalities of Multi-Color Nanoparticle Cellular Bar-Coding
Rees, P, Brown, MR, Wills, JW & Summers, H 2016, Combinatorial Chemistry and High Throughput Screening, vol 19, no. 5, pp. 362-369.

Quantifying the cellular uptake of semiconductor quantum dot nanoparticles by analytical electron microscopy
Hondow, N, Brown, MR, Starborg, T, Monteith, AG, Brydson, R, Summers, HD, Rees, P & Brown, A 2016, Journal of Microscopy, vol 261, no. 2, pp. 167-176. DOI:

Label-free cell cycle analysis for high-throughput imaging flow cytometry
Blasi, T, Hennig, H, Summers, HD, Theis, FJ, Cerveira, J, Patterson, JO, Davies, D, Filby, A, Carpenter, AE & Rees, P 2016, Nature Communications, vol 7, 10256. DOI:

Reduced cationic nanoparticle cytotoxicity based on serum masking of surface potential
McConnell, KI, Shamsudeen, S, Meraz, IM, Mahadevan, TS, Ziemys, A, Rees, P, Summers, HD & Serda, RE 2016, Journal of Biomedical Nanotechnology, vol 12, no. 1, pp. 154-164. DOI:

Quantum resonance of nanometre-scale metal-ZnO-metal structure and its application in sensors
Li, L & Rees, P 2016, AIP Advances, vol 6, no. 1, 015003. DOI:

A new imaging platform for visualizing biological effects of non-invasive radiofrequency electric-field cancer hyperthermia
Corr, SJ, Shamsudeen, S, Vergara, LA, Chak-Shing Ho, J, Ware, MJ, Keshishian, V, Yokoi, K, Savage, DJ, Meraz, IM, Kaluarachchi, W, Cisneros, BT, Raoof, M, Nguyen, DT, Zhang, Y, Wilson, LJ, Summers, H, Rees, P, Curley, SA & Serda, RE 2015, PLoS ONE, vol 10, no. 8, e0136382. DOI:

A modulated segmented contact method for the measurement of internal optical mode loss
Rees, PE, Pascoe, R, Smowton, PM & Blood, P 2015, . in Conference on Lasers and Electro-Optics Europe - Technical Digest. vol. 2015-August, 7183414, Institute of Electrical and Electronics Engineers Inc. Conference on Lasers and Electro-Optics, CLEO 2015, San Jose, United States, 10-15 May.

Radiofrequency treatment alters cancer cell phenotype
Ware, MJ, Tinger, S, Colbert, KL, Corr, SJ, Rees, P, Koshkina, N, Curley, S, Summers, HD & Godin, B 2015, Scientific reports, vol 5, 12083. DOI:

A modulated segmented contact method for the measurement of internal optical mode loss
Rees, PE, Pascoe, R, Smowton, PM & Blood, P 2015, . in CLEO: Science and Innovations, CLEO-SI 2015. Optical Society of America (OSA), pp. 2267, CLEO: Science and Innovations, CLEO-SI 2015, San Jose, United States, 10-15 May. DOI:

Poisson-event-based analysis of cell proliferation
Summers, HD, Wills, JW, Brown, MR & Rees, P 2015, Cytometry Part A, vol 87, no. 5, pp. 385-392. DOI:

Statistical prediction of nanoparticle delivery: From culture media to cell
Brown, MR, Hondow, N, Brydson, R, Rees, P, Brown, AP & Summers, HD 2015, Nanotechnology, vol 26, no. 15, 155101. DOI:

Measurement of molecular mixing at a conjugated polymer interface by specular and off-specular neutron scattering
James, D, Higgins, AM, Rees, P, Geoghegan, M, Brown, MR, Chang, SS, Môn, D, Cubitt, R, Dalgliesh, R & Gutfreund, P 2015, Soft Matter, vol 11, no. 48, pp. 9393-9403. DOI:

Quantifying nanoparticle-cell interactions
Hondow, N, Brown, A, Summers, HD, Rowan Brown, M, Rees, P, Holton, MD & Brydson, R 2014, Microscopy and Microanalysis, vol 20, no. 3, pp. 1300-1301. DOI:

Analysis of the influence of cell heterogeneity on nanoparticle dose response
Ware, MJ, Godin, B, Singh, N, Majithia, R, Shamsudeen, S, Serda, RE, Meissner, KE, Rees, P & Summers, HD 2014, ACS Nano, vol 8, no. 7, pp. 6693-6700. DOI:

Nanoparticle vesicle encoding for imaging and tracking cell populations
Rees, P, Wills, JW, Brown, MR, Tonkin, J, Holton, MD, Hondow, N, Brown, AP, Brydson, R, Millar, V, Carpenter, AE & Summers, HD 2014, Nature Methods, vol 11, no. 11, pp. 1177-1181. DOI:

Optical tracking of drug release from porous silicon delivery vectors
Tonkin, JA, Shamsudeen, S, Brown, MR, Serda, RE, Rees, P & Summers, HD 2014, IET Optoelectronics, vol 8, no. 2, pp. 113-116. DOI:

The health literacy of children who are 'looked after' by the state
Rees, P & Holding, M 2013, . in Health Literacy: Developments, Issues and Outcomes. Nova Science Publishers, Inc. pp. 189-199.

A method for evaluating the use of fluorescent dyes to track proliferation in cell lines by dye dilution
Begum, J, Day, W, Henderson, C, Purewal, S, Cerveira, J, Summers, H, Rees, P, Davies, D & Filby, A 2013, Cytometry Part A, vol 83, no. 12, pp. 1085-1095. DOI: