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Paolo Zanotti Fregonara, MD, PhD

Associate Research Professor of Neurology, Institute for Academic Medicine
Associate Research Member; Director, PET Core Facility, Research Institute
Houston Methodist
Weill Cornell Medical College


Lab Link


Biography

Dr. Paolo Zanotti Fregonara earned his Medical Degree in 1998 and board certification in Nuclear Medicine in 2002 from the University of Milan, Italy. He earned a Master’s Degree in Radiobiology/Radioprotection in 2005 and a PhD in Medical Physics in 2009 from the University of Paris, France. He held appointments at University hospitals in Paris and Bordeaux, the Atomic Energy Commission PET center in Orsay, France, and the Molecular Imaging Branch (NIMH) in Bethesda, Maryland, before rejoining in 2016 the Houston Methodist Research Institute as the director of the PET core imaging lab and chair of the Radiation Safety Committee.

Areas Of Expertise

PET Kinetic modeling Dosimetry
Publications

On the role of interim fluorine-18–labeled fluorodeoxyglucose positron emission tomography in early-stage favorable hodgkin lymphoma
Hindié, E, Mesguich, C & Zanotti-Fregonara, P 2017, Journal of Clinical Oncology, vol 35, no. 24, pp. 2851-2852. DOI: 10.1200/JCO.2017.73.8369

Linear no-threshold hypothesis at the hospital: When raDioprotection becomes a nosocomial hazard
Zanotti-Fregonara, P & HinDie, E 2017, Journal of Nuclear Medicine, vol 58, no. 8, pp. 1355. DOI: 10.2967/jnumed.117.190983

Predicting the outcome of peptide receptor radionuclide therapy in neuroendocrine tumors: the importance of dual-tracer imaging
Zanotti-Fregonara, P, Morgat, C, Champion, C & Hindié, E 2017, European Journal of Nuclear Medicine and Molecular Imaging, pp. 1-2. DOI: 10.1007/s00259-017-3667-7

Performing nuclear medicine examinations in pregnant women
Zanotti-Fregonara, P & Hindie, E 2017, Physica Medica. DOI: 10.1016/j.ejmp.2017.05.043

Standardized input function for 18F-FDG PET studies in mice: A cautionary study
Meyer, M, Le-Bras, L, Fernandez, P & Zanotti-Fregonara, P 2017, PLoS ONE, vol 12, no. 1, e0168667. DOI: 10.1371/journal.pone.0168667

Re: 13I and 124I accumulation in a thymic cyst
Zanotti-Fregonara, P & Hindie, E 2017, Clinical Nuclear Medicine, vol 42, no. 7, pp. 576. DOI: 10.1097/RLU.0000000000001700

18F-FDG Imaging of Chronic Inflammation Associated With Promontofixation of the Uterus
Meyer, M, Fernandez, P & Zanotti-Fregonara, P 2017, Clinical nuclear medicine, vol 42, no. 1, pp. 42-43.

18F-FDG Imaging of Chronic Inflammation Associated With Promontofixation of the Uterus
Meyer, M, Fernandez, P & Zanotti-Fregonara, P 2017, Clinical nuclear medicine, vol 42, no. 1, pp. 42-43.

Re: 131I and 124I Accumulation in a Thymic Cyst
Zanotti-Fregonara, P & Hindie, E 2016, Clinical Nuclear Medicine. DOI: 10.1097/RLU.0000000000001520

18F-FDG Imaging of Chronic Inflammation Associated With Promontofixation of the Uterus
Meyer, M, Fernandez, P & Zanotti-Fregonara, P 2017, Clinical Nuclear Medicine, vol 42, no. 1, pp. 42-43. DOI: 10.1097/RLU.0000000000001420

New fetal dose estimates from 18F-FDG administered during pregnancy: Standardization of dose calculations and estimations with voxel-based anthropomorphic phantoms
Zanotti-Fregonara, P, Chastan, M, Edet-Sanson, A, Ekmekcioglu, O, Erdogan, EB, Hapdey, S, Hindie, E & Stabin, MG 2016, Journal of Nuclear Medicine, vol 57, no. 11, pp. 1760-1763. DOI: 10.2967/jnumed.116.173294

Putative Physiopathological Explanation for the “Sock Sign” in Bone Scans
de Vaugelade, C, Pinaquy, JB, Fernandez, P, Bordenave, L, Hindie, E & Zanotti-Fregonara, P 2016, Clinical Nuclear Medicine. DOI: 10.1097/RLU.0000000000001255

Dose deposits from90Y,177Lu,111In, and161Tb in micrometastases of various sizes: Implications for radiopharmaceutical therapy
Hindie, E, Zanotti-Fregonara, P, Quinto, MA, Morgat, C & Champion, C 2016, Journal of Nuclear Medicine, vol 57, no. 5, pp. 759-764. DOI: 10.2967/jnumed.115.170423

Interest of [18F]fluorodeoxyglucose positron emission tomography/computed tomography for the diagnosis of relapse in patients with spinal infection: A prospective study
Dauchy, FA, Dutertre, A, Lawson-Ayayi, S, de Clermont-Gallerande, H, Fournier, C, Zanotti-Fregonara, P, Dutronc, H, Vital, JM, Dupon, M & Fernandez, P 2016, Clinical Microbiology and Infection, vol 22, no. 5, pp. 438-443. DOI: 10.1016/j.cmi.2015.12.028

Measuring specific receptor binding of a PET radioligand in human brain without pharmacological blockade: The genomic plot
Veronese, M, Zanotti-Fregonara, P, Rizzo, G, Bertoldo, A, Innis, RB & Turkheimer, FE 2016, NeuroImage, vol 130, pp. 1-12. DOI: 10.1016/j.neuroimage.2016.01.058

Plasma radiometabolite correction in dynamic PET studies: Insights on the available modeling approaches
Tonietto, M, Rizzo, G, Veronese, M, Fujita, M, Zoghbi, SS, Zanotti-Fregonara, P & Bertoldo, A 2016, Journal of Cerebral Blood Flow and Metabolism, vol 36, no. 2, pp. 326-339. DOI: 10.1177/0271678X15610585

The PET radioligand 18F-FIMX images and quantifies metabotropic glutamate receptor 1 in proportion to the regional density of its gene transcript in human brain
Zanotti-Fregonara, P, Xu, R, Zoghbi, SS, Liow, JS, Fujita, M, Veronese, M, GladDing, RL, Rallis-Frutos, D, Hong, J, Pike, VW & Innis, RB 2016, Journal of Nuclear Medicine, vol 57, no. 2, pp. 242-247. DOI: 10.2967/jnumed.115.162461

Comparison between three promising ß-emitting radionuclides, 67Cu, 47Sc and 161Tb, with emphasis on doses delivered to minimal residual disease
Champion, C, Quinto, MA, Morgat, C, Zanotti-Fregonara, P & Hindié, E 2016, Theranostics, vol 6, no. 10, pp. 1611-1618. DOI: 10.7150/thno.15132

New perspectives offered by nuclear medicine for the imaging and therapy of multiple myeloma
Mesguich, C, Zanotti-Fregonara, P & Hindié, E 2016, Theranostics, vol 6, no. 2, pp. 287-290. DOI: 10.7150/thno.14400

Improved models for plasma radiometabolite correction and their impact on kinetic quantification in PET studies
Tonietto, M, Veronese, M, Rizzo, G, Zanotti-Fregonara, P, Lohith, TG, Fujita, M, Zoghbi, SS & Bertoldo, A 2015, Journal of Cerebral Blood Flow and Metabolism, vol 35, no. 9, pp. 1462-1469. DOI: 10.1038/jcbfm.2015.61