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Murali Chintagumpala, MD

Full Clinical Member, Research Institute
Houston Methodist


Biography

Dr. Chintagumpala is the principal investigator of two multi-institutional studies designed to improve survival in patients with osteosarcoma and the treatment of medulloblastoma. He is a member of the Brain Tumor Committee and study chairman for a new protocol for children with low-grade gliomas. He is also a key investigator in a study to better delineate the risk factors for the development of metastases in children with retinoblastomas, and a gene therapy study at the Texas Children's Cancer Center for the treatment of children with retinoblastomas.

Areas Of Expertise

Neuro-oncology Solid Tumors Retinoblastoma Osteosarcoma Wilms Tumors
Publications

Exploratory analysis of ERCC2 DNA methylation in survival among pediatric medulloblastoma patients
Banfield, E, Brown, AL, Peckham, EC, Rednam, SP, Murray, J, Okcu, MF, Mitchell, LE, Chintagumpala, MM, Lau, CC, Scheurer, ME & Lupo, PJ 2016, Cancer Epidemiology, vol 44, pp. 161-166. DOI:

Neuroendocrine Tumor of the Appendix in Children
Wu, H, Chintagumpala, M, Hicks, J, Nuchtern, JG, Okcu, MF & Venkatramani, R 2016, Journal of Pediatric Hematology/Oncology. DOI:

Primitive myxoid mesenchymal tumor of infancy involving chest wall in an infant: A case report and clinicopathologic correlation
Foster, JH, Vasudevan, SA, Hicks, MJ, Schady, D & Chintagumpala, M 2016, Pediatric and Developmental Pathology, vol 19, no. 3, pp. 244-248. DOI:

Comparing intelligence quotient change after treatment with proton versus photon radiation therapy for pediatric brain tumors
Kahalley, LS, Ris, MD, Grosshans, DR, Okcu, MF, Paulino, AC, Chintagumpala, M, Moore, BD, Guffey, D, Minard, CG, Stancel, HH & Mahajan, A 2016, Journal of Clinical Oncology, vol 34, no. 10, pp. 1043-1049. DOI:

Preservation of KIT genotype in a novel pair of patient-derived orthotopic xenograft mouse models of metastatic pediatric CNS germinoma
Lindsay, H, Huang, Y, du, Y, Braun, FK, Teo, WY, Kogiso, M, Qi, L, Zhang, H, Zhao, S, Mao, H, Lin, F, Baxter, P, Su, JM, Terashima, K, Perlaky, L, Chintagumpala, M, Adesina, A, Lau, CC, Williams Parsons, D & Li, XN 2016, Journal of Neuro-Oncology, pp. 1-10. DOI:

Multimodality Treatment of Pediatric Esthesioneuroblastoma
Venkatramani, R, Pan, H, Furman, WL, Marron, JM, Haduong, J, Friedrich-Medina, P, Mahajan, A, Bavle, A, Wu, H & Chintagumpala, M 2016, Pediatric Blood and Cancer, vol 63, no. 3, pp. 465-470. DOI:

Risk-Based Therapy for Localized Osteosarcoma
Venkatramani, R, Murray, J, Helman, L, Meyer, W, Hicks, MJ, Krance, R, Lau, C, Jo, E & Chintagumpala, M 2016, Pediatric Blood and Cancer, vol 63, no. 3, pp. 412-417. DOI:

Mucoepidermoid Carcinoma in Children: A Single Institutional Experience
Techavichit, P, Hicks, MJ, López-Terrada, DH, Quintanilla, NM, Guillerman, RP, Sarabia, SF, Sayeed, H, Nuchtern, JG, Paulino, AC, Muscal, JA, Okcu, MF & Chintagumpala, M 2016, Pediatric Blood and Cancer, vol 63, no. 1, pp. 27-31. DOI:

Correlation of Insurance, Race, and Ethnicity with Pathologic Risk in a Controlled Retinoblastoma Cohort. A Children's Oncology Group Study
Green, AL, Chintagumpala, M, Krailo, M, Langholz, B, Albert, D, Eagle, R, Cockburn, M, Chevez-Barrios, P & Rodriguez-Galindo, C 2015, Ophthalmology. DOI:

Recurrent internal tandem duplications of BCOR in clear cell sarcoma of the kidney
Roy, A, Kumar, V, Zorman, B, Fang, E, Haines, KM, Doddapaneni, H, Hampton, OA, White, S, Bavle, AA, Patel, NR, Eldin, KW, John Hicks, M, Rakheja, D, Leavey, PJ, Skapek, SX, Amatruda, JF, Nuchtern, JG, Chintagumpala, MM, Wheeler, DA, Plon, SE, Sumazin, P & Parsons, DW 2015, Nature Communications, vol 6, 8891. DOI:

Advances in Management of Pediatric Ependymomas
Lin, FY & Chintagumpala, M 2015, Current Oncology Reports, vol 17, no. 10, 47. DOI:

Is CMV a target in pediatric glioblastoma? Expression of CMV proteins, pp65 and IE1-72 and CMV nucleic acids in a cohort of pediatric glioblastoma patients
Wakefield, A, Pignata, A, Ghazi, A, Ashoori, A, Hegde, M, Landi, D, Gray, T, Scheurer, ME, Chintagumpala, M, Adesina, A, Gottschalk, S, Hicks, J, Powell, SZ & Ahmed, N 2015, Journal of Neuro-Oncology, vol 125, no. 2, pp. 307-315. DOI:

Imaging changes in pediatric intracranial ependymoma patients treated with proton beam radiation therapy compared to intensity modulated radiation therapy This work was presented previously at the 56th Annual American Society for Radiation Oncology Meeting, San Francisco, CA, Sep 2014; And International Symposium for Pediatric Neuro-Oncology, Singapore, July 2014.
Gunther, JR, Sato, M, Chintagumpala, M, Ketonen, L, Jones, JY, Allen, PK, Paulino, AC, Okcu, MF, Su, JM, Weinberg, J, Boehling, NS, Khatua, S, Adesina, A, Dauser, R, Whitehead, WE & Mahajan, A 2015, International Journal of Radiation Oncology Biology Physics, vol 93, no. 1, pp. 54-63. DOI:

Pulmonary function after treatment for embryonal brain tumors on SJMB03 that included craniospinal irradiation
Green, DM, Merchant, TE, Billups, CA, Stokes, DC, Broniscer, A, Bartels, U, Chintagumpala, M, Hassall, TE, Gururangan, S, McCowage, GB, Heath, JA, Cohn, RJ, Fisher, MJ, Srinivasan, A, Robinson, GW & Gajjar, A 2015, International Journal of Radiation Oncology Biology Physics, vol 93, no. 1, pp. 47-53. DOI:

Vismodegib exerts targeted efficacy against recurrent sonic hedgehog - Subgroup medulloblastoma: Results from phase II Pediatric Brain Tumor Consortium studies PBTC-025B and PBTC-032
Robinson, GW, Orr, BA, Wu, G, Gururangan, S, Lin, T, Qaddoumi, I, Packer, RJ, Goldman, S, Prados, MD, Desjardins, A, Chintagumpala, M, Takebe, N, Kaste, SC, Rusch, M, Allen, SJ, Onar-Thomas, A, Stewart, CF, Fouladi, M, Boyett, JM, Gilbertson, RJ, Curran, T, Ellison, DW & Gajjar, A 2015, Journal of Clinical Oncology, vol 33, no. 24, pp. 2646-2654. DOI:

Routine use of recombinant human bone morphogenetic protein-2 in posterior fusions of the pediatric spine and incidence of cancer
Sayama, C, Willsey, M, Chintagumpala, M, Brayton, A, Briceño, V, Ryan, SL, Luerssen, TG, Hwang, SW & Jea, A 2015, Journal of Neurosurgery: Pediatrics, vol 16, no. 1, pp. 4-13. DOI:

Erratum: Common variants in ACYP2 influence susceptibility to cisplatin-induced hearing loss (Nature Genetics (2015) 47 (263-266))
Xu, H, Robinson, GW, Huang, J, Lim, JYS, Zhang, H, Bass, JK, Broniscer, A, Chintagumpala, M, Bartels, U, Gururangan, S, Hassall, T, Fisher, M, Cohn, R, Yamashita, T, Teitz, T, Zuo, J, Onar-Thomas, A, Gajjar, A, Stewart, CF & Yang, JJ 2015, Nature Genetics, vol 47, no. 4, pp. 423. DOI:

Common variants in ACYP2 influence susceptibility to cisplatin-induced hearing loss
Xu, H, Robinson, GW, Huang, J, Lim, JYS, Zhang, H, Bass, JK, Broniscer, A, Chintagumpala, M, Bartels, U, Gururangan, S, Hassall, T, Fisher, M, Cohn, R, Yamashita, T, Teitz, T, Zuo, J, Onar-Thomas, A, Gajjar, A, Stewart, CF & Yang, JJ 2015, Nature Genetics, vol 47, no. 3, pp. 263-266. DOI:

A phase 1 and pharmacokinetic study of enzastaurin in pediatric patients with refractory primary central nervous system tumors: A pediatric brain tumor consortium study
Kilburn, LB, Kocak, M, Decker, RL, Wetmore, C, Chintagumpala, M, Su, J, Goldman, S, Banerjee, A, Gilbertson, R, Fouladi, M, Kun, L, Boyett, JM & Blaney, SM 2015, Neuro-Oncology, vol 17, no. 2, pp. 303-311. DOI:

A pilot study using carboplatin, vincristine, and temozolomide in children with progressive/symptomatic low-grade glioma: A Children's Oncology Group study†
Chintagumpala, M, Eckel, SP, Krailo, M, Morris, M, Adesina, A, Packer, R, Lau, C & Gajjar, A 2015, Neuro-Oncology, vol 17, no. 8, pp. 1132-1138. DOI: