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Milos Kojic, PhD

Professor of Nanomedicine, Institute for Academic Medicine
Full Member, Research Institute
Houston Methodist


Biography

Dr. Kojic's research focuses on modeling of biological and drug delivery transport phenomena, and multiscale modeling. This includes transport of molecules and bio-mechanical interactions of micro-nano particles.

Description of Research

Dr. Kojic was a Professor of Mechanics at the University of Kragujevac in Serbia and is a senior research scientist in the Physiology Program a the Harvard School of Public Health. He was also a visiting scholar at MIT in Boston; a research engineer at ADINA R&D software company in Watertown, MA; a research professor at the University of Texas Medical Center at Houston; a senior researcher at Zastava Automobili in Kragujevac, Serbia; and director of the R&D Center for Bioengineering in Kragujevac. Dr. Kojic is a member of several academic organizations, including the Serbian Academy of Sciences and Arts.

The focus of Dr. Kojic's research includes computational methods and software development. He has conducted pioneering work in modern numerical methods and engineering software development in Serbia, while mentoring a significant number of Ph.D. students and researchers. The result of this effort is a general-purpose finite element program PAK for solids, fluids, mass and heat transfer, biomechanics, and coupled problems; and a large group of researchers who are part of a "Serbian School" in computational mechanics.

Dr. Kojic is the first president of the Serbian Society for Computational Mechanics, Editor of the Journal of the Serbian Society for Computational Mechanics, and the founder of the R&D Center for Bioengineering, Kragujevac. His initial work in computer modeling primarily focused on solid mechanics and is summarized in the textbook: M. Kojic and K. J. Bathe: Inelastic Analysis of Solids and Structures, Springer, 2005. His more recent research has focused on modeling of bioengineering problems, and the results are summarized in the textbook: M. Kojic, N. Filipovic, B. Stojanovic, N. Kojic: Computer Modeling in Bioengineering- Theoretical Background, Examples and Software, J. Wiley and Sons, 2008.

Areas Of Expertise

Computational methods Coupling imaging Computer simulations
Education & Training

, Rice University
, University of Belgrade
Publications

Computational analysis of drug transport in tumor microenvironment as a critical compartment for nanotherapeutic pharmacokinetics
Ziemys, A, Klemm, S, Milosevic, M, Yokoi, K, Ferrari, M & Kojic, M 2016, Drug Delivery, vol 23, no. 7, pp. 2524-2531. DOI:

Computational analysis of drug transport in tumor microenvironment as a critical compartment for nanotherapeutic pharmacokinetics
Ziemys, A, Klemm, S, Milosevic, M, Yokoi, K, Ferrari, M & Kojic, M 2016, Drug Delivery, vol 23, no. 7, pp. 2524-2531. DOI:

Mass release curves as the constitutive curves for modeling diffusive transport within biological tissue
Kojic, M, Milosevic, M, Kojic, N, Koay, EJ, Fleming, JB, Ferrari, M & Ziemys, A 2016, pp. DOI: 10.1016/j.compbiomed.2016.06.026.

A review of models in bioengineering developed by the group led by Miloš Kojic in the period 2006-2016
Kojic, M 2016, Journal of the Serbian Society for Computational Mechanics, vol 10, no. 1, pp. 5-19.

A MODEL FOR DRUG TRANSPORT IN TUMOR
Kojic, M, Simic, V, Ferrari, M, Koay, EJ & Ziemys, A 2016, . in ECCOMAS Congress 2016, Crete Island, Greece, 5-10 June.

A review of models in bioengineering developed by the group led by Miloš Kojic in the period 2006-2016
Kojic, M 2016, Journal of the Serbian Society for Computational Mechanics, vol 10, no. 1, pp. 5-19.

Hybrid SPECT/MSCT 3D computational preoperative simulation in breast cancer surgery
Nikolic, D, Matovic, M, Jeremic, M, Cvetkovic, A, Ninkovic, S, Kojic, M & Filipovic, N 2015, . in 2015 IEEE 15th International Conference on Bioinformatics and Bioengineering, BIBE 2015., 7367670, IEEE, 15th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2015, Belgrade, Serbia, 2-4 November. DOI:

Computational models for convective and diffusive drug transport in capillaries and tissue
Kojic, M, Milosevic, M, Isailovic, V, Simic, V, Ferrari, M & Ziemys, A 2015, . in 2015 IEEE 15th International Conference on Bioinformatics and Bioengineering, BIBE 2015., 7367633, IEEE, 15th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2015, Belgrade, Serbia, 2-4 November. DOI:

Liposomal doxorubicin extravasation controlled by phenotype-specific transport properties of tumor microenvironment and vascular barrier
Yokoi, K, Chan, D, Kojic, M, Milosevic, M, Engler, D, Matsunami, R, Tanei, T, Saito, Y, Ferrari, M & Ziemys, A 2015, Journal of Controlled Release, vol 217, pp. 293-299. DOI:

Capillary collagen as the physical transport barrier in drug delivery to tumor microenvironment
Ziemys, A , Yokoi, K & Kojic, M 2015, Tissue barriers, vol 3, no. 3, pp. e1037418. DOI:

Physicochemical properties affect the synthesis, controlled delivery, degradation and pharmacokinetics of inorganic nanoporous materials
Yazdi, IK, Ziemys, A, Evangelopoulos, M, Martinez, JO, Kojic, M & Tasciotti, E 2015, Nanomedicine, vol 10, no. 19, pp. 3057-3075. DOI:

A multi-scale FE model for convective-diffusive drug transport within tumor and large vascular networks
Kojic, M, Milosevic, M, Kojic, N, Starosolski, Z, Ghaghada, K, Serda, R, Annapragada, A, Ferrari, M & Ziemys, A 2015, Computer Methods in Applied Mechanics and Engineering, vol 294, pp. 100-122. DOI:

Mass partitioning effects in diffusion transport
Kojic, M, Milosevic, M, Wu, S, Blanco, E, Ferrari, M & Ziemys, A 2015, Physical Chemistry Chemical Physics, vol 17, no. 32, pp. 20630-20635. DOI:

A computational study of circulating large tumor cells traversing microvessels
Kojic, N, Miloševic, M, Petrovic, D, Isailovic, V, Sarioglu, AF, Haber, DA, Kojic, M & Toner, M 2015, Computers in Biology and Medicine, vol 63, pp. 187-195. DOI:

Coupling fluid and solid domains in modeling drug transport within tumor
Kojic, M, Milosevic, M, Simic, V, Ziemys, A & Ferrari, M 2015, . in COUPLED PROBLEMS 2015 - Proceedings of the 6th International Conference on Coupled Problems in Science and Engineering. International Center for Numerical Methods in Engineering, pp. 583-592, 6th International Conference on Computational Methods for Coupled Problems in Science and Engineering, COUPLED PROBLEMS 2015, Venice, Italy, 18-20 May.

Capillary-wall collagen as a biophysical marker of nanotherapeutic permeability into the tumor microenvironment
Yokoi, K , Kojic, M, Milosevic, M, Tanei, T, Ferrari, M & Ziemys, A 2014, Cancer Research, vol 74, no. 16, pp. 4239-4246. DOI:

Polymer nanoparticles encased in a cyclodextrin complex shell for potential site- and sequence-specific drug release
Ruiz-Esparza, GU, Wu, S, Segura-Ibarra, V, Cara, FE, Evans, KW, Milosevic, M, Ziemys, A, Kojic, M, Meric-Bernstam, F, Ferrari, M & Blanco, E 2014, Advanced Functional Materials, vol 24, no. 30, pp. 4753-4761. DOI:

A multiscale MD-FE model of diffusion in composite media with internal surface interaction based on numerical homogenization procedure
Kojic, M, Milosevic, M, Kojic, N, Kim, K, Ferrari, M & Ziemys, A 2014, Computer Methods in Applied Mechanics and Engineering, vol 269, pp. 123-138. DOI:

Hyperelastic behavior of porcine aorta segment under extension-inflation tests fitted with various phenomenological models
Veljkovic, D, Rankovic, VJ, Pantovic, SB, Rosic, MA & Kojic, MR 2014, Acta of Bioengineering and Biomechanics, vol 16, no. 3, pp. 37-45. DOI:

A computational study of trajectories of micro- and nano-particles with different shapes in flow through small channels
Isailovic, V, Kojic, M, Milosevic, M, Filipovic, N, Kojic, N, Ziemys, A & Ferrari, M 2014, Journal of the Serbian Society for Computational Mechanics, vol 8, no. 2, pp. 14-28.