Michael Thrall, MD

Associate Professor of Clinical Pathology and Genomic Medicine, Institute for Academic Medicine
Assistant Clinical Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Dr. Michael J. Thrall works as both a cytopathologist and a general surgical pathologist with a primary research interest in cytopathology. He is also participating in the formation of the new imaging pathology fellowship program and the associated research projects. Dr. Thrall attended medical school and completed his AP/CP residency training, including a surgical pathology fellowship, at the University of Minnesota in Minneapolis, Minnesota. He then went on to a cytopathology fellowship at the University of Rochester in Rochester, New York. He is a member of the American Society of Cytopathology ASC Bulletin Committee and the American Society for Clinical Pathology.

Description of Research

Dr. Thrall's research interests include cytopathology and imaging pathology, with a recent focus upon endometrial and pancreatic carcinomas and interpretation of atypical squamous cells detected in Papanicolau tests.

Areas Of Expertise

Cytopathology Imaging pathology
Education & Training

, University of Rochester
, University of Minnesota

Effect of lower anogenital squamous terminology recommendations on the use of p16 immunohistochemistry and the proportion of high-grade diagnoses in cervical biopsy specimens
Thrall, MJ 2016, American Journal of Clinical Pathology, vol 145, no. 4, pp. 524-530. DOI:

Glandular lesions of the cervix in clinical practice: A cytology, histology, and human papillomavirus correlation study from 2 institutions
Miller, RA, Mody, DR, Tams, KC & Thrall, MJ 2015, Archives of Pathology and Laboratory Medicine, vol 139, no. 11, pp. 1431-1436. DOI:

Human Lung Fibroblasts Inhibit Non-Small Cell Lung Cancer Metastasis in Ex Vivo 4D Model
Mishra, DK, Compean, SD, Thrall, MJ, Liu, X, Massarelli, E, Kurie, JM & Kim, MP 2015, Annals of Thoracic Surgery, vol 100, no. 4, pp. 1167-74; discussion 1174. DOI:

The clinical impact of including pictures in Papanicolaou test reports
Thrall, MJ, Janssen, BL & Mody, DR 2015, Journal of the American Society of Cytopathology, vol 4, no. 3, pp. 122-127. DOI:

Validation of multiple whole slide imaging scanners based on the guideline from the College of American Pathologists pathology and laboratory quality center
Thrall, MJ, Wimmer, JL & Schwartz, MR 2015, Archives of Pathology and Laboratory Medicine, vol 139, no. 5, pp. 656-664. DOI:

Ex vivo four-dimensional lung cancer model mimics metastasis
Mishra, DK, Creighton, CJ, Zhang, Y, Chen, F, Thrall, MJ & Kim, MP 2015, Annals of Thoracic Surgery, vol 99, no. 4, pp. 1149-1156. DOI:

Circulating tumor cells from 4D model have less integrin beta 4 expression
Mishra, DK, Scott, KL, Wardwell-Ozgo, JM, Thrall, MJ & Kim, MP 2015, Journal of Surgical Research, vol 193, no. 2, pp. 745-53. DOI:

Body cavity fluids.
Thrall, MJ 2014, Cancer treatment and research, vol 160, pp. 185-210.

Circulating tumor cells from a 4-dimensional lung cancer model are resistant to cisplatin
Vishnoi, M, Mishra, DK, Thrall, MJ, Kurie, JM & Kim, MP 2014, Journal of Thoracic and Cardiovascular Surgery, vol 148, no. 3, pp. 1056-1064. DOI:

Miniaturized CARS microendoscope probe design for label-free intraoperative imaging
Chen, X, Wang, X, Xu, X, Cheng, J, Liu, Z, Weng, S, Thrall, MJ, Goh, AC, McCormick, DT, Wong, K & Wong, STC 2014, . in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 8947, 89470Y, SPIE, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XII, San Francisco, CA, United States, 3-6 February. DOI:

Multimodal non-linear optical imaging for label-free differentiation of lung cancerous lesions from normal and desmoplastic tissues
Xu, X, Cheng, J, Thrall, MJ, Liu, Z, Wang, X & Wong, STC 2013, Biomedical Optics Express, vol 4, no. 12, pp. 2855-2868. DOI:

The impact of LSIL-H terminology on patient follow-up patterns: A comparison with LSIL and ASC-H
Thrall, MJ, Galfione, SK & Smith, DA 2013, Diagnostic Cytopathology, vol 41, no. 11, pp. 960-964. DOI:

Only a small fraction of high-grade cervical lesions are discovered after an interpretation of atypical squamous cells of undetermined significance when using imager-assisted, liquid-based Papanicolaou tests and the Bethesda 2001 system
Khan, KA, Smith, DA & Thrall, MJ 2013, Archives of Pathology and Laboratory Medicine, vol 137, no. 7, pp. 936-941. DOI:

Quantitative label-free multimodality nonlinear optical imaging for in situ differentiation of cancerous lesions
Xua, X, Li, X, Cheng, J, Liu, Z, Thrall, MJ, Wang, X, Wang, Z & Wong, STC 2013, . in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 8565, 85653A, Photonic Therapeutics and Diagnostics IX, San Francisco, CA, United States, 2-7 February. DOI:

Lipomatosis coli, a mimicker of familial polyposis
Zarrin-Khameh, N, Haas, EM, Ro, J & Thrall, MJ 2013, Annals of Diagnostic Pathology, vol 17, no. 2, pp. 210-213. DOI:

Differential diagnosis of lung carcinoma with coherent anti-stokes raman scattering imaging
Gao, L, Wang, Z, Li, F, Hammoudi, AA, Thrall, MJ, Cagle, PT & Wong, STC 2012, Archives of Pathology and Laboratory Medicine, vol 136, no. 12, pp. 1502-1510. DOI:

A 60-year-old woman with an incidentally discovered right renal mass
Stamatakis, L, Cheng, PJ, Ho, PL, Thrall, MJ, Mayer, WA, Miles, BJ & Link, RE 2012, Urology, vol 80, no. 6, pp. 1183-1186. DOI:

Human Lung Cancer Cells Grown in an Ex Vivo 3D Lung Model Produce Matrix Metalloproteinases Not Produced in 2D Culture
Mishra, DK , Sakamoto, JH , Thrall, MJ, Baird, BN, Blackmon, SH, Ferrari, M, Kurie, JM & Kim, MP 2012, PLoS ONE, vol 7, no. 9, e45308. DOI:

Differential diagnosis of lung carcinoma with three-dimensional quantitative molecular vibrational imaging
Gao, L, Hammoudi, AA, Li, F, Thrall, MJ, Cagle, PT, Chen, Y, Yang, J, Xia, X, Fan, Y, Massoud, Y, Wang, Z & Wong, STC 2012, Journal of Biomedical Optics, vol 17, no. 6, 066017. DOI:

Human lung cancer cells grown on acellular rat lung matrix create perfusable tumor nodules
Mishra, DK , Thrall, MJ, Baird, BN, Ott, HC, Blackmon, SH, Kurie, JM & Kim, MP 2012, Annals of Thoracic Surgery, vol 93, no. 4, pp. 1075-1081. DOI: