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Mauro Ferrari, PhD

Ernest Cockrell, Jr. Presidential Distinguished Chair, President & CEO, Research Institute
Director & Professor of Nanomedicine, Institute for Academic Medicine
Executive Vice President, Houston Methodist
Senior Associate Dean and Professor of Medicine, Weill Cornell Medical College
Houston Methodist
Weill Cornell Medical College


Research Lab


mferrari@houstonmethodist.org
Biography

Mauro Ferrari, PhD, is the Executive Vice President of Houston Methodist and the President and CEO of the Houston Methodist Research Institute where he is the Ernest Cockrell Jr. Presidential Distinguished Chair. As the Director of the Houston Methodist Institute for Academic Medicine, Ferrari oversees all research and education programs at Houston Methodist, over 1,200 research employees and credentialed clinicians executing more than 800 clinical protocols. He also serves as the Senior Associate Dean of the Weill Cornell Medical College, the primary academic affiliate of Houston Methodist and holds Adjunct and Honorary Professorships at many universities around the world.

Ferrari is the founder of biomedical nano/micro-technology, especially in their applications to drug delivery, cell transplantation, implantable bioreactors, and other innovative therapeutic modalities. Dr. Ferrari served as special expert on nanotechnology at the National Cancer Institute in 2003-2005, providing leadership for the formulation, refinement, and approval of the NCI's Alliance for Nanotechnology in Cancer, currently the world's largest program in medical nanotechnology.

He has to his credit more than 350 publications, including seven books and is the inventor of 30 issued patents in the US and Europe. Throughout his academic career, he has supervised trainees and students who have gone on to senior faculty positions at premier universities like Oxford, Massachusetts Institute of Technology (MIT), University of California Berkeley, University of California San Francisco, Duke University, University of Washington, and Ohio State University. Dr. Ferrari's degrees are in Mathematics (Padova, Italy), and Mechanical Engineering (M.S., & Ph.D., U.C. Berkeley).

His seminal contributions to the field of biomedical nanotechnology have been recognized through numerous awards and accolades, including: Founders Award - Controlled Release Society, the Wallace H. Coulter Award for Biomedical Innovation and Entrepreneurship, the ETH Zürich Stodola Medal, Blaise Pascal Medal in Biomedical Engineering - European Academy of Sciences, and the Shannon Director's Award of the National Institutes of Health. Dr. Ferrari is a Fellow of the American Society of Mechanical Engineers, American Academy for the Advancement of Science and American Institute for Medical and Biological Engineering. He also holds honorary doctorates in Electrical Engineering and Biotechnology from the University of Palermo and the University of Naples “Federico II”, respectively.

His career research and development portfolio totals over $50 million, including support from the NCI, NIH, DoD, NASA, NSF, DARPA, DoE, the state of Texas, the state of Ohio, the Ohio State University, and several private enterprises. He began his academic career at the University of California, Berkeley, where he tenured in Material Science, Civil Engineering, and Bioengineering. Upon recruitment to the Ohio State University, he served as the Edgar Hendrickson Professor of Biomedical Engineering, Professor of Internal Medicine, Mechanical Engineering and Materials Science. He was also the Associate Vice President, Health Sciences Technology and Commercialization, Associate Director of the Dorothy M. Davis Heart and Lung Research Institute and Director of the Biomedical Engineering Center. Upon recruitment to Houston, he served as professor and chair of the nanomedicine department at the University of Texas Health Science Center.

Description of Research

Nanomedicine for oncology, traumatic injury, cardiovascular disease, infectious pathologies, and diabetes
Nanofluidics
Biomedical Microtechnology (BioMEMS)
Drug delivery
Proteomics and peptidomics for early detection and therapeutic monitoring
Cell transplantation, regenerative medicine, and tissue engineering
Biosensors and bioseparation technology
Multiscale discrete/continuum mechanics and biomechanics
Bioethics

Areas Of Expertise

Nanomedicine Cancer Nanofluidics Drug delivery Biomedical microtechnology (BioMEMS)
Education & Training

Dottore , Universita' di Padova
PhD , University of California Berkeley
Publications

A chloroquine-induced macrophage-preconditioning strategy for improved nanodelivery
Wolfram, J, Nizzero, S, Liu, H, Li, F, Zhang, G, Li, Z, Shen, H, Blanco, E & Ferrari, M 2017, Scientific reports, vol 7, no. 1, pp. 13738. DOI: 10.1038/s41598-017-14221-2

Contribution of Kupffer cells to liposome accumulation in the liver
Samuelsson, E, Shen, H, Blanco, E, Ferrari, M & Wolfram, J 2017, Colloids and Surfaces B: Biointerfaces, vol 158, pp. 356-362. DOI: 10.1016/j.colsurfb.2017.07.014

Nanoparticles administered intrapericardially enhance payload myocardial distribution and retention
Segura-Ibarra, V, Cara, FE, Wu, S, Iruegas-Nunez, DA, Wang, S, Ferrari, M, Ziemys, A, Valderrabano, M & Blanco, E 2017, Journal of Controlled Release, vol 262, pp. 18-27. DOI: 10.1016/j.jconrel.2017.07.012

Tumor progression effects on drug vector access to tumor-associated capillary bed
Kiseliovas, V, Milosevic, M, Kojic, M, Mazutis, L, Kai, M, Liu, YT, Yokoi, K, Ferrari, M & Ziemys, A 2017, Journal of Controlled Release, vol 261, pp. 216-222. DOI: 10.1016/j.jconrel.2017.05.031

Gemcitabine enhances the transport of nanovector-albumin-bound paclitaxel in gemcitabine-resistant pancreatic ductal adenocarcinoma
Borsoi, C, Leonard, F, Lee, Y, Zaid, M, Elganainy, D, Alexander, JF, Kai, M, Liu, YT, Kang, Y, Liu, X, Koay, EJ, Ferrari, M, Godin, B & Yokoi, K 2017, Cancer Letters, vol 403, pp. 296-304. DOI: 10.1016/j.canlet.2017.06.026

A composite smeared finite element for mass transport in capillary systems and biological tissue
Kojic, M, Milosevic, M, Simic, V, Koay, EJ, Fleming, JB, Nizzero, S, Kojic, N, Ziemys, A & Ferrari, M 2017, Computer Methods in Applied Mechanics and Engineering, vol 324, pp. 413-437. DOI: 10.1016/j.cma.2017.06.019

Targeting autocrine CCL5-CCR5 axis reprograms immunosuppressive myeloid cells and reinvigorates antitumor immunity
Ban, Y, Mai, J, Li, X, Mitchell-Flack, M, Zhang, T, Zhang, L, Chouchane, L, Ferrari, M, Shen, H & Ma, X 2017, Cancer Research, vol 77, no. 11, pp. 2857-2868. DOI: 10.1158/0008-5472.CAN-16-2913

Highly efficient genome editing of human hematopoietic stem cells via a nano-silicon-blade delivery approach
Ma, Y, Han, X, Quintana Bustamante, O, Bessa De Castro, R, Zhang, K, Zhang, P, Li, Y, Liu, Z, Liu, X, Ferrari, M, Hu, Z, Carlos Segovia, J & Qin, L 2017, Integrative Biology (United Kingdom), vol 9, no. 6, pp. 548-554. DOI: 10.1039/c7ib00060j

Enhancing Vascularization through the Controlled Release of Platelet-Derived Growth Factor-BB
Minardi, S, Pandolfi, L, Taraballi, F, Wang, X, De Rosa, E, Mills, ZD, Liu, X, Ferrari, M & Tasciotti, E 2017, ACS Applied Materials and Interfaces, vol 9, no. 17, pp. 14566-14575. DOI: 10.1021/acsami.6b13760

Lipopolyplex potentiates anti-tumor immunity of mRNA-based vaccination
Persano, S, Guevara, ML, Li, Z, Mai, J, Ferrari, M, Pompa, PP & Shen, H 2017, Biomaterials, vol 125, pp. 81-89. DOI: 10.1016/j.biomaterials.2017.02.019

Multi-step encapsulation of chemotherapy and gene silencing agents in functionalized mesoporous silica nanoparticles
Shen, J, Liu, H, Mu, C, Wolfram, J, Zhang, W, Kim, HC, Zhu, G, Hu, Z, Ji, LN, Liu, X, Ferrari, M, Mao, ZW & Shen, H 2017, Nanoscale, vol 9, no. 16, pp. 5329-5341. DOI: 10.1039/c7nr00377c

Rapamycin nanoparticles localize in diseased lung vasculature and prevent pulmonary arterial hypertension
Segura-Ibarra, V, Amione-Guerra, J, Cruz-Solbes, AS, Cara, FE, Iruegas-Nunez, DA, Wu, S, Youker, KA, Bhimaraj, A, Torre-Amione, G, Ferrari, M, Karmouty-Quintana, H, Guha, A & Blanco, E 2017, International Journal of Pharmaceutics, vol 524, no. 1-2, pp. 257-267. DOI: 10.1016/j.ijpharm.2017.03.069

Pioneering medical advances through nanofluidic implantable technologies
Hood, RL, Hood, GD, Ferrari, M & Grattoni, A 2017, Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology. DOI: 10.1002/wnan.1455

Taking the vehicle out of drug delivery
Shen, J, Wolfram, J, Ferrari, M & Shen, H 2017, Materials Today. DOI: 10.1016/j.mattod.2017.01.013

Post-nano strategies for drug delivery: multistage porous silicon microvectors
Venuta, A, Wolfram, J, Shen, H & Ferrari, M 2017, Journal of Materials Chemistry B, vol 5, no. 2, pp. 207-219. DOI: 10.1039/C6TB01978A

Exosomes as Reconfigurable Therapeutic Systems
Conlan, RS, Pisano, S, Oliveira, MI, Ferrari, M & Mendes Pinto, I 2017, Trends in Molecular Medicine. DOI: 10.1016/j.molmed.2017.05.003

Enhancing cancer immunotherapy through nanotechnology-mediated tumor infiltration and activation of immune cells
Shen, H, Sun, T, Hoang, HH, Burchfield, JS, Hamilton, GF, Mittendorf, EA & Ferrari, M 2017, Seminars in Immunology. DOI: 10.1016/j.smim.2017.09.002

The active modulation of drug release by an ionic field effect transistor for an ultra-low power implantable nanofluidic system
Bruno, G, Canavese, G, Liu, X, Filgueira, CS, Sacco, A, Demarchi, D, Ferrari, M & Grattoni, A 2016, Nanoscale, vol 8, no. 44, pp. 18718-18725. DOI: 10.1039/c6nr06235k

Enzyme-responsive multistage vector for drug delivery to tumor tissue
Mi, Y, Wolfram, J, Mu, C, Liu, X, Blanco, E, Shen, H & Ferrari, M 2016, Pharmacological Research, vol 113, pp. 92-99. DOI: 10.1016/j.phrs.2016.08.024

Strategies for improving drug delivery: nanocarriers and microenvironmental priming
Khalid, A, Persano, S, Shen, H, Zhao, Y, Blanco, E, Ferrari, M & Wolfram, J 2016, Expert Opinion on Drug Delivery, pp. 1-13. DOI: 10.1080/17425247.2017.1243527