R. Mark Ghobrial, MD, PhD

Professor of Surgery, Institute for Academic Medicine
Full Member, Research Institute
Director, Sherrie and Alan Conover Center for Liver Disease & Transplantation
Houston Methodist
Weill Cornell Medical College


Biography

After receiving his Bachelor of Medicine and Bachelor of Surgery degrees from Cairo University Medical School in Cairo, Egypt, Dr. Ghobrial completed several surgical residencies in the United Kingdom and the United States. While a surgery resident at University of Texas Health Science Center in Houston, Texas, he completed a PhD in Immunology at the UT Graduate School of Biomedical Sciences in 1994. After residency, he accepted a position as clinical instructor in the Department of Surgery at the David Geffen School of Medicine at University of California, Los Angeles (UCLA) and was awarded a Dumont-UCLA Transplant Fellowship. He received his full professorship in 2005 and served as Director of the Pancreas Transplant Program and Living Donor Liver Transplantation, and Service Director for Liver, Pancreas, and Small Bowel Transplantation. He was recruited to the Houston Methodist Hospital in 2008.

Description of Research

One of the primary goals of Dr. Ghobrial´s research is to increase donor tolerance to organ transplants and allografts. Dr. Ghobrial has shown in preclinical studies that tolerizing the host to dominant donor epitopes induces tolerance in the recipient. By engineering chimeric proteins, or proteins that contain sequences from both donor and recipient, and exposing the recipient to these proteins prior to tissue graft, peripheral, long-term tolerance is induced. Dr. Ghobrial also has a long-standing interest in the effects of Hepatitis (B and C) on transplantation patients.

Areas Of Expertise

Transplantation Hepatocellular carcinoma
Education & Training

, Dumont-UCLA Transplant Center
, The University of Texas Health Science Center at Houston
, University of Cairo Medical School
, The University of Texas Health Science Center
Publications

Markers of T cell Inhibition Predict Development of Infections after Liver Transplantation
Mysore, K, Ghobrial, RM, Minze, LJ, Graviss, E, Nguyen, DTM, Perez, K & Li, XC 2016, American Association for the Study of Liver Diseases-AASLD 2016, Boston, United States, 11/11/16 - 11/15/16, .

Dissonant response of M0/M2 and M1 bone-marrow-derived macrophages to RhoA pathway interference
Liu, Y, Chen, W, Minze, LJ, Kubiak, JZ, Li, XC, Ghobrial, RM & Kloc, M 2016, Cell and Tissue Research, pp. 1-14. DOI:

Dissonant response of M0/M2 and M1 bone-marrow-derived macrophages to RhoA pathway interference
Liu, Y, Chen, W, Minze, LJ, Kubiak, JZ, Li, XC, Ghobrial, RM & Kloc, M 2016, Cell and Tissue Research, pp. 1-14. DOI:

Dissonant response of M0/M2 and M1 bone-marrow-derived macrophages to RhoA pathway interference
Liu, Y, Chen, W, Minze, LJ, Kubiak, JZ, Li, XC, Ghobrial, RM & Kloc, M 2016, Cell and Tissue Research, pp. 1-14. DOI:

Graft-Infiltrating Macrophages Adopt an M2 Phenotype and Are Inhibited by Purinergic Receptor P2X7 Antagonist in Chronic Rejection
Wu, C, Zhao, Y, Xiao, X, Fan, Y, Kloc, M, Liu, W, Ghobrial, RM, Lan, P, He, X & Li, XC 2016, American Journal of Transplantation, vol 16, no. 9, pp. 2563-2573. DOI:

The Costimulatory Receptor OX40 Inhibits Interleukin-17 Expression through Activation of Repressive Chromatin Remodeling Pathways
Xiao, X, Shi, X, Fan, Y, Wu, C, Zhang, X, Minze, L, Liu, W, Ghobrial, RM, Lan, P & Li, XC 2016, Immunity, vol 44, no. 6, pp. 1271-1283. DOI:

The Emerging Role of Nanotechnology in Cell and Organ Transplantation
Tasciotti, E, Cabrera, FJ, Evangelopoulos, M, Martinez, JO, Thekkedath, UR, Kloc Stepkowska, M, Ghobrial, RM, Li, XC, Grattoni, A & Ferrari, M 2016, Transplantation. DOI:

Mouse macrophage polarity and ROCK1 activity depend on RhoA and non-apoptotic Caspase 3
Liu, Y, Minze, LJ, Mumma, L, Li, XC, Ghobrial, RM & Kloc Stepkowska, M 2016, Experimental Cell Research, vol 341, no. 2, pp. 225-236. DOI:

ROCK inhibition impedes macrophage polarity and functions
Liu, Y, Tejpal, N, You, J, Li, XC, Ghobrial, RM & Kloc, M 2016, Cellular Immunology, vol 300, pp. 54-62. DOI:

Efficacy and cost-effectiveness of voriconazole prophylaxis for prevention of invasive aspergillosis in high-risk liver transplant recipients
Balogh, J, Gordon Burroughs, S, Boktour, M, Patel, S, Saharia, A, Ochoa, RA, McFadden, R, Victor, DW, Ankoma-Sey, V, Galati, J, Monsour, HP, Fainstein, V, Li, XC, Grimes, KA, Gaber, AO, Aloia, T & Ghobrial, RM 2016, Liver Transplantation, vol 22, no. 2, pp. 163-170.

Efficacy and cost-effectiveness of voriconazole prophylaxis for prevention of invasive aspergillosis in high-risk liver transplant recipients
Balogh, J, Gordon Burroughs, S, Boktour, M, Patel, S, Saharia, A, Ochoa, RA, McFadden, R, Victor, DW, Ankoma-Sey, V, Galati, J, Monsour, HP, Fainstein, V, Li, XC, Grimes, KA, Gaber, AO, Aloia, T & Ghobrial, RM 2016, Liver Transplantation, vol 22, no. 2, pp. 163-170. DOI:

Graft-Infiltrating Macrophages Adopt an M2 Phenotype and Are Inhibited by Purinergic Receptor P2X7 Antagonist in Chronic Rejection
Wu, C, Zhao, Y, Xiao, X, Fan, Y, Kloc, M, Liu, W, Ghobrial, RM, Lan, P, He, X & Li, XC 2016, American Journal of Transplantation. DOI:

Hepatocellular carcinoma: a review
Balogh, J, Victor, III, DW, Asham, EH, Burroughs, SG, Boktour, M, Saharia, A, Li, X, Ghobrial, RM & Monsour, HP 2016, Journal of hepatocellular carcinoma, vol 3, pp. 41-53. DOI:

Macrophage/monocyte-specific deletion of Ras homolog gene family member A (RhoA) downregulates fractalkine receptor and inhibits chronic rejection of mouse cardiac allografts
Liu, Y, Chen, W, Wu, C, Minze, LJ, Kubiak, JZ, Li, XC, Kloc, M & Ghobrial, RM 2016, Journal of Heart and Lung Transplantation. DOI:

Post-Transplant Length of Stay and Discharge Disposition Is Impacted By Pre-Transplant Location But Not Transplant Survival
Victor, III, DW, Monsour, Jr. HP, Boktour, MR, Gordon Burroughs, S, Saharia, A, McFadden, R, Ankoma-Sey, V, Egwim, C, Galati, J, Mobley, CM, Gaber, AO & Ghobrial, RM.

Clostridium Difficile Infection in Liver Transplant Recipients
Aderinto-Adike, AO, Boktour, MR, Iqbal, S, Gudsoorkar, VS, Victor, III, DW, Saharia, A, Gordon Burroughs, S, Ghobrial, RM & Monsour, Jr. HP .

Use of the Stanford Integrated Psychosocial Assessment for Transplant in Patients Transplanted for Decompensated Alcoholic Liver Disease Who Did Not Meet Traditional Sobriety Goals
Ontiveros, J, Victor, III, DW, Bell, M, Monsour, Jr. HP, Gordon Burroughs, S, Galati, J, McFadden, R & Ghobrial, RM.

Early Liver Transplantation in Severe Alcoholic Hepatitis: A Multi-Center, Retrospective, Cohort Study
Victor, III, DW, Lee, B, Rinella, M, Potosky, D, Li, Z, Ghobrial, RM & Monsour, HP .

Single-Center Analysis of Adult, Combined Heart-Liver Transplant (CHLT) Recipients
Victor, III, DW, Monsour, HP, Boktour, MR, Aderinto-Adike, AO, Gordon Burroughs, S, Saharia, A, Trachtenberg, B, Bhimaraj, A, Gaber, AO, Estep, J & Ghobrial, RM.

Incidence and Risk Factors for Infectious Complications in Liver Transplant Patients Converted to Everolimus
Islam, A, Devos, JM, Teeter, LD, Graviss, E, Gordon Burroughs, S, Saharia, A, Mobley, CL, Gaber, AO & Ghobrial, RM 2015, American Journal of Transplantation, vol 2015, no. 15 (suppl 3).