Malgorzata Kloc

Malgorzata Kloc, PhD

Research Professor of Surgery, Academic Institute
Associate Research Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Biography

Prior to completing her postdoctoral training in Canada, Dr. Kloc-Stepkowska was a tenured Associate Professor in the Department of Zoology at the University of Warsaw, Poland. She also served as a Research Associate in the Department of Biology at Carleton University in Ottawa, Canada. While completing her postdoctoral training, Dr. Kloc-Stepkowska earned the AHFMR Research Award from the University of Calgary and the MRC Biotechnology Training Award from Dalhousie University. She joined the University of Texas M.D. Anderson Cancer Center as a Research Scientist in the Department of Molecular Genetics in 1987, and became an Associate Professor in the Department of Biochemistry and Molecular Biology there in 2006. Dr. Kloc-Stepkowska joined the Houston Methodist Research Institute in 2008.

Description of Research

Dr. Kloc-Stepkowska’s research focuses on investigations into the role of structural RNA in the organization of cellular cytoskeleton. She has numerous publications in the medical literature and her current studies are funded by the National Science Foundation. Dr. Kloc-Stepkowska also works closely with Dr. R. Mark Ghobrial on transplant immunomodulation studies using allochimeric molecules to improve transplant acceptance.

Areas Of Expertise

Immunology Transplant biology Structural RNA Cytoskeleton
Education & Training

Postdoctoral Fellowship, Department of Biochemistry, Dalhousie University, Halifax, Nova Scotia
Postdoctoral Fellowship, Department of Biology, University of Calgary, Calgary, Alberta
Postdoctoral Fellowship, Department of Chemistry, Saint Mary's University, Halifax, Nova Scotia
PhD, University of Warsaw
MS, University of Warsaw
Publications

Osteocalcin protects islet identity in low-density lipoprotein receptor knockout mice on high-fat diet
Beamish, CA, Lee, YK, Gaber, AO, Chanana, P, Graviss, EA, Kloc, M, Gaber, MW, Hsueh, WA & Sabek, OM 2024, , Journal of Endocrinology, vol. 261, no. 1, e230352. https://doi.org/10.1530/JOE-23-0352

Invertebrate Immunity, Natural Transplantation Immunity, Somatic and Germ Cell Parasitism, and Transposon Defense
Kloc, M, Halasa, M, Kubiak, JZ & Ghobrial, RM 2024, , International journal of molecular sciences, vol. 25, no. 2, 1072. https://doi.org/10.3390/ijms25021072

Germline and Somatic Cell Syncytia in Insects
Kloc, M, Tworzydlo, W & Szklarzewicz, T 2024, , Results and Problems in Cell Differentiation, vol. 71, pp. 47-63. https://doi.org/10.1007/978-3-031-37936-9_3

The Role of Human and Animal Monocytes and Macrophages in Homeostasis and Disease
Kloc, M & Kubiak, JZ 2023, , International journal of molecular sciences, vol. 24, no. 22, 16397. https://doi.org/10.3390/ijms242216397

Why Do We Study Aquatic Organisms?
Kloc, M & Kubiak, JZ 2023, , International journal of molecular sciences, vol. 24, no. 21, 15807. https://doi.org/10.3390/ijms242115807

Immunomodulatory Effect of Infectious Disease of a Breastfed Child on the Cellular Composition of Breast Milk
Tomaszewska, A, Jeleniewska, A, Porebska, K, Królikowska, K, Rustecka, A, Lipinska-Opalka, A, Bedzichowska, A, Zdanowski, R, Aleksandrowicz, K, Kloc, M & Kalicki, B 2023, , Nutrients, vol. 15, no. 17, 3844. https://doi.org/10.3390/nu15173844

Coronavirus Disease Pathophysiology: Biomarkers, Potential New Remedies, Comorbidities, Long COVID-19, Post Pandemic Epidemiological Surveillance
Kubiak, JZ & Kloc, M 2023, , International journal of molecular sciences, vol. 24, no. 15, 12236. https://doi.org/10.3390/ijms241512236

CDC6 as a Key Inhibitory Regulator of CDK1 Activation Dynamics and the Timing of Mitotic Entry and Progression
El Dika, M, Dudka, D, Kloc, M & Kubiak, JZ 2023, , Biology, vol. 12, no. 6, 855. https://doi.org/10.3390/biology12060855

Seahorse Male Pregnancy as a Model System to Study Pregnancy, Immune Adaptations, and Environmental Effects
Kloc, M 2023, , International journal of molecular sciences, vol. 24, no. 11, 9712. https://doi.org/10.3390/ijms24119712

Comparative transcriptome profile of mouse macrophages treated with the RhoA/Rock pathway inhibitors Y27632, Fingolimod (Gilenya), and Rezurock (Belumosudil, SLx-2119)
Subuddhi, A, Uosef, A, Zou, D, Ubelaker, HV, Ghobrial, RM & Kloc, M 2023, , International Immunopharmacology, vol. 118, 110017, pp. 110017. https://doi.org/10.1016/j.intimp.2023.110017

Macrophages and stem/progenitor cells interplay in adipose tissue and skeletal muscle: a review
Kloc, M, Uosef, A, Ubelaker, HV, Kubiak, JZ & Ghobrial, RM 2023, , Stem Cell Investigation, vol. 10, no. 9, pp. 9. https://doi.org/10.21037/sci-2023-009

Memory Macrophages
Kloc, M, Kubiak, JZ, Zdanowski, R & Ghobrial, RM 2022, , International journal of molecular sciences, vol. 24, no. 1, 38. https://doi.org/10.3390/ijms24010038

7T MRI and molecular studies of Dotarem (gadoterate meglumine) retention in macrophages.
Uosef, A, Subuddhi, A, Lu, A, Ubelaker, HV, Karmonik, C, Wosik, J, Ghobrial, RM & Kloc, M 2022, , Journal of Magnetic Resonance Open, vol. 12-13, 100085. https://doi.org/10.1016/j.jmro.2022.100085

Macrophage-, Dendritic-, Smooth Muscle-, Endothelium-, and Stem Cells-Derived Foam Cells in Atherosclerosis
Kloc, M, Kubiak, JZ & Ghobrial, RM 2022, , International journal of molecular sciences, vol. 23, no. 22, 14154. https://doi.org/10.3390/ijms232214154

Recent Progress in Research on COVID-19 Pathophysiology: Biomarkers, Repurposed Drugs, Viral Invasiveness, SARS-CoV-2 Genetic Diversity, the Crystal Structure of Viral Proteins, and the Molecular and Cellular Outcomes of COVID-19
Kubiak, JZ & Kloc, M 2022, , International journal of molecular sciences, vol. 23, no. 22, 14194. https://doi.org/10.3390/ijms232214194

Monocyte and Macrophage Function Diversity
Kloc, M & Kubiak, JZ 2022, , International journal of molecular sciences, vol. 23, no. 20, 12404. https://doi.org/10.3390/ijms232012404

Dissecting Physiopathology of COVID-19
Kubiak, JZ & Kloc, M 2022, , International journal of molecular sciences, vol. 23, no. 17, 9602. https://doi.org/10.3390/ijms23179602

Dissecting Physiopathology of COVID-19
Kubiak, JZ & Kloc, M 2022, , International journal of molecular sciences, vol. 23, no. 17, 9602. https://doi.org/10.3390/ijms23179602, https://doi.org/10.3390/ijms23179602

Giant Multinucleated Cells in Aging and Senescence—An Abridgement
Kloc, M, Uosef, A, Subuddhi, A, Kubiak, JZ, Piprek, RP & Ghobrial, RM 2022, , Biology, vol. 11, no. 8, 1121. https://doi.org/10.3390/biology11081121

Transplantation of insulin-producing cells derived from human mesenchymal stromal/stem cells into diabetic humanized mice
Ghoneim, MA, Gabr, MM, Refaie, AF, El-Halawani, SM, Al-issawi, MM, Elbassiouny, BL, Kader, MAAE, Ismail, AM, Zidan, MF, Karras, MS, Magar, RW, Khater, SM, Ashamallah, SA, Zakaria, MM & Kloc, M 2022, , Stem Cell Research and Therapy, vol. 13, no. 1, 350, pp. 350. https://doi.org/10.1186/s13287-022-03048-y

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