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Malgorzata Kloc, PhD

Research Professor of Surgery, Institute for Academic Medicine
Associate Research Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Prior to completing her postdoctoral training in Canada, Dr. Kloc-Stepkowska was a tenured Associate Professor in the Department of Zoology at the University of Warsaw, Poland. She also served as a Research Associate in the Department of Biology at Carleton University in Ottawa, Canada. While completing her postdoctoral training, Dr. Kloc-Stepkowska earned the AHFMR Research Award from the University of Calgary and the MRC Biotechnology Training Award from Dalhousie University. She joined the University of Texas M.D. Anderson Cancer Center as a Research Scientist in the Department of Molecular Genetics in 1987, and became an Associate Professor in the Department of Biochemistry and Molecular Biology there in 2006. Dr. Kloc-Stepkowska joined the Houston Methodist Research Institute in 2008.

Description of Research

Dr. Kloc-Stepkowska’s research focuses on investigations into the role of structural RNA in the organization of cellular cytoskeleton. She has numerous publications in the medical literature and her current studies are funded by the National Science Foundation. Dr. Kloc-Stepkowska also works closely with Dr. R. Mark Ghobrial on transplant immunomodulation studies using allochimeric molecules to improve transplant acceptance.

Areas Of Expertise

Immunology Transplant biology Structural RNA Cytoskeleton
Education & Training

Postdoctoral Fellowship, Department of Biochemistry, Dalhousie University, Halifax, Nova Scotia
Postdoctoral Fellowship, Department of Biology, University of Calgary, Calgary, Alberta
PhD, University of Warsaw
MS, University of Warsaw
Postdoctoral Fellowship, Department of Chemistry, Saint Mary's University, Halifax, Nova Scotia

Rho-specific Guanine nucleotide exchange factors (Rho-GEFs) inhibition affects macrophage phenotype and disrupts Golgi complex
Chen, W, Zhao, Y, Li, XC, Kubiak, JZ, Ghobrial, RM & Kloc, M 2017, International Journal of Biochemistry and Cell Biology, vol 93, pp. 12-24. DOI: 10.1016/j.biocel.2017.10.009

The phenotype of peritoneal mouse macrophages depends on the mitochondria and ATP/ADP homeostasis
Chen, W, Sandoval, H, Kubiak, JZ, Li, XC, Ghobrial, RM & Kloc, M 2017, Cellular Immunology. DOI: 10.1016/j.cellimm.2017.11.003

Selection of mitochondria in female germline cells: is Balbiani body implicated in this process?
Bilinski, SM, Kloc, M & Tworzydlo, W 2017, Journal of Assisted Reproduction and Genetics, vol 34, no. 11, pp. 1405-1412. DOI: 10.1007/s10815-017-1006-3

Cell adhesion molecules expression pattern indicates that somatic cells arbitrate gonadal sex of differentiating bipotential fetal mouse gonad
Piprek, RP, Kolasa, M, Podkowa, D, Kloc, M & Kubiak, JZ 2017, Mechanisms of Development, vol 147, pp. 17-27. DOI: 10.1016/j.mod.2017.07.001

Macrophages and RhoA Pathway in Transplanted Organs
Liu, Y, Kubiak, JZ, Li, XC, Ghobrial, RM & Kloc, M 2017, . in Results and Problems in Cell Differentiation. vol. 62, Results and Problems in Cell Differentiation, vol. 62, Springer-Verlag, pp. 365-376. DOI: 10.1007/978-3-319-54090-0_15

Asymmetric divisions in oogenesis
Bilinski, SM, Kubiak, JZ & Kloc, M 2017, . in Results and Problems in Cell Differentiation. vol. 61, Results and Problems in Cell Differentiation, vol. 61, Springer-Verlag, pp. 211-228. DOI: 10.1007/978-3-319-53150-2_9

Role of Cdc6 During Oogenesis and Early Embryo Development in Mouse and Xenopus laevis
Borsuk, E, Jachowicz, J, Kloc, M, Tassan, JP & Kubiak, JZ 2017, . in Results and Problems in Cell Differentiation. vol. 59, Results and Problems in Cell Differentiation, vol. 59, Springer-Verlag, pp. 201-211. DOI: 10.1007/978-3-319-44820-6_7

Results and Problems in Cell Differentiation: Macrophages- Origin, Functions and Biointervention
Kloc, M (ed.) 2017, . vol. 62, 1st edn, Springer International Publishing. DOI:

Exogenous Molecule and Organelle Delivery in Oogenesis
Kloc, M & Kubiak, JZ 2017, . in Oocytes: Maternal Information and Functions. vol. 63, Switzerland. DOI: 10.1007/978-3-319-60855-6_1

Macrophage/monocyte-specific deletion of Ras homolog gene family member A (RhoA) downregulates fractalkine receptor and inhibits chronic rejection of mouse cardiac allografts
Liu, Y, Chen, W, Wu, C, Minze, LJ, Kubiak, JZ, Li, XC, Kloc, M & Ghobrial, RM 2016, Journal of Heart and Lung Transplantation. DOI: 10.1016/j.healun.2016.08.011

Macrophages as effector cells in acute and chronic rejection.
Liu, Y, Kloc, M & Li, XC 2016, Topical Collection on Immunology, no. 4, vol. 3, vol. 3, Springer International Publishing. DOI: 10.1007/s40472-016-0130-9

Dissonant response of M0/M2 and M1 bone-marrow-derived macrophages to RhoA pathway interference
Liu, Y, Chen, W, Minze, LJ, Kubiak, JZ, Li, XC, Ghobrial, RM & Kloc, M 2016, Cell and Tissue Research, pp. 1-14. DOI: 10.1007/s00441-016-2491-x

Graft-Infiltrating Macrophages Adopt an M2 Phenotype and Are Inhibited by Purinergic Receptor P2X7 Antagonist in Chronic Rejection
Wu, C, Zhao, Y, Xiao, X, Fan, Y, Kloc, M, Liu, W, Ghobrial, RM, Lan, P, He, X & Li, XC 2016, American Journal of Transplantation, vol 16, no. 9, pp. 2563-2573. DOI: 10.1111/ajt.13808

Cytoskeleton and Cytoskeleton-Bound RNA Visualization in Frog and Insect Oocytes
Kloc, M, Bilinski, S & Kubiak, JZ 2016, Methods in molecular biology (Clifton, N.J.), vol 1457, pp. 179-90. DOI: 10.1007/978-1-4939-3795-0_13

Gametic synapses, nanotubes and sperm RNAs - Redefining the origin of maternal determinants
Kloc, M, Kubiak, JZ & Bilinski, SM 2016, Mechanisms of Development, vol 141, pp. 1-3. DOI: 10.1016/j.mod.2016.07.002

Early development of the gonads: Origin and differentiation of the somatic cells of the genital ridges
Piprek, RP, Kloc, M & Kubiak, JZ 2016, Results and Problems in Cell Differentiation, vol 58. DOI: 10.1007/978-3-319-31973-5_1

Hermes (Rbpms) is a Critical Component of RNP Complexes that Sequester Germline RNAs during Oogenesis
Aguero, T, Zhou, Y, Kloc, M, Chang, P, Houliston, E & King, ML 2016, Journal of developmental biology, vol 4, no. 1. DOI: 10.3390/jdb4010002

Mouse macrophage polarity and ROCK1 activity depend on RhoA and non-apoptotic Caspase 3
Liu, Y, Minze, LJ, Mumma, L, Li, XC, Ghobrial, RM & Kloc Stepkowska, M 2016, Experimental Cell Research, vol 341, no. 2, pp. 225-236. DOI: 10.1016/j.yexcr.2016.02.004

ROCK inhibition impedes macrophage polarity and functions
Liu, Y, Tejpal, N, You, J, Li, XC, Ghobrial, RM & Kloc, M 2016, Cellular Immunology, vol 300, pp. 54-62. DOI: 10.1016/j.cellimm.2015.12.005

The Emerging Role of Nanotechnology in Cell and Organ Transplantation
Tasciotti, E, Cabrera, FJ, Evangelopoulos, M, Martinez, JO, Thekkedath, UR, Kloc Stepkowska, M, Ghobrial, RM, Li, XC, Grattoni, A & Ferrari, M 2016, Transplantation. DOI: 10.1097/TP.0000000000001100