Luan Truong, MD

Professor of Pathology and Genomic Medicine, Institute for Academic Medicine
Full Member, Research Institute
Houston Methodist
Weill Cornell Medical College


Biography

After completing his training in renal pathology in 1984, Dr. Truong joined the Department of Pathology at Baylor College of Medicine. He was promoted to Associate Professor in 1990, and Professor in 1996. He currently holds full-time faculty appointment in the Department of Pathology, Weill Medical College of Cornell University and in the Houston Methodist Research Institute. He also hold adjunct faculty appointment in the Departments of Pathology and Medicine, Baylor College of Medicine. He has been the attending pathologist for the Harris County Hospital District and Houton Methodist since 1984, and has served as Chief of Nephropathology since 1989. Dr. Truong also serves as the Director of the Pathology Core for the interdepartmental NIH-funded O’Brien Research Center on Renal Inflammation. Well recognized in the area of nephropathology, Dr. Truong actively participates in scholarly activities in this field as section editor and peer-reviewer for many scientific journals, as leader in professional societies, and as lecturer in national and international scientific meetings. 

Description of Research

Dr. Truong´s research interests involve surgical pathology and nephropathology. In the area of surgical pathology, he is interested in using morphology to define new diseases and to improve the diagnostic accuracy of known diseases. He combines traditional clinicopathologic observation with novel immunohistochemical techniques to study case materials drawn from more than 30,000 surgical pathology specimens submitted to the Department of Pathology and Genomic Medicine annually. In the area of clinical nephropathology, Dr. Truong is interested in assessing the pathogenesis and natural behavior of several specific renal diseases using a clinico-pathologic approach, and has access to more than 10,000 renal biopsies accumulated in the renal pathology laboratory suitable for this purpose. In the area of experimental nephropathology, Dr. Truong’s research focuses on the pathogenesis of primary chronic tubulointerstitial nephritis. He has established a model of chronic obstructive uropathy by unilateral ligation of the ureter and has focused on cell cycle abnormality, including apoptosis and cell proliferation of tubular cells and interstitial cells as a crucial element in chronic tubulointerstitial injury. He is currently investigating preconditioning as a mechanism to attenuate acute tubular cell injury. He recently made the novel observation that activation of cell survival mechanisms, including the PI3 kinase pathway and survivin, may serve as important protective mechanisms. He also collaborates extensively with other investigators in the Texas Medical Center and elsewhere in terms of morphologic support and structure-function correlation studies on various renal diseases.

Areas Of Expertise

Kidney diseases Acute tubular cell injury chronic tubulointerstitial injury Renal transplantation Renal neoplasms
Education & Training

Residency , Baylor College of Medicine
MD , Pennsylvania State University College of Medicine
Publications

Sarcoid-like granulomas in renal cell carcinoma: The Houston Methodist Hospital experience
Arora, K, Divatia, MK, Truong, L, Shen, SS, Ayala, AG & Ro, JY 2017, Annals of Diagnostic Pathology, vol 31, pp. 62-65. DOI: 10.1016/j.anndiagpath.2017.07.003

Role of renal drug exposure in polymyxin B-induced nephrotoxicity
Manchandani, P, Zhou, J, Babic, JT, Ledesma, KR, Truong, LD & Tama, VH 2017, Antimicrobial Agents and Chemotherapy, vol 61, no. 4, 02391-16. DOI: 10.1128/AAC.02391-16

Role of mechanistic target of rapamycin (mTOR) in renal function and ischaemia–reperfusion induced kidney injury
Alshaman, R, Truong, L & Oyekan, A 2016, Clinical and Experimental Pharmacology and Physiology, vol 43, no. 11, pp. 1087-1096. DOI: 10.1111/1440-1681.12648

Macrophage A2A Adenosine Receptors Are Essential to Protect from Progressive Kidney Injury
Truong, LD, Trostel, J, McMahan, R, Chen, JF & Garcia, GE 2016, American Journal of Pathology, vol 186, no. 10, pp. 2601-2613. DOI: 10.1016/j.ajpath.2016.06.017

MiR-93 regulates Msk2-mediated chromatin remodelling in diabetic nephropathy
Badal, SS, Wang, Y, Long, J, Corcoran, DL, Chang, BH, Truong, LD, Kanwar, YS, Overbeek, PA & Danesh, FR 2016, Nature Communications, vol 7, 12076. DOI: 10.1038/ncomms12076

Characterization of polymyxin B biodistribution and disposition in an animal model
Manchandani, P, Zhou, J, Ledesma, KR, Truong, LD, Chow, DSL, Eriksen, JL & Tam, VH 2016, Antimicrobial Agents and Chemotherapy, vol 60, no. 2, pp. 1029-1034. DOI: 10.1128/AAC.02445-15

Enigma (partially) resolved: Phospholipase A2 receptor is the cause of “idiopathic” membranous glomerulonephritis
Truong, LD & Seshan, SV 2015, American Journal of Physiology - Renal Physiology, vol 309, no. 12, pp. F1000-F1002. DOI: 10.1152/ajprenal.00264.2015

Obstructive nephropathy: What the surgical pathologist should know
Truong, L & Mai, K 2015, Pathology Case Reviews, vol 20, no. 6, pp. 250-255. DOI: 10.1097/PCR.0000000000000118

Severe nephrotoxic nephritis following conditional and kidney-specific knockdown of stanniocalcin-1
Huang, L, Lou, Y, Ju, H, Zhang, L, Pan, JSC, Ross, A, Sun, Y, Truong, LD & Sheikh-Hamad, D 2015, PLoS ONE, vol 10, no. 9, e0138440. DOI: 10.1371/journal.pone.0138440

Invasive urothelial carcinoma exhibiting basal cell immunohistochemical markers: A variant of urothelial carcinoma associated with aggressive features
Mai, KT, Truong, LD, Ball, CG, Williams, P, Flood, TA & Belanger, EC 2015, Pathology Research and Practice, vol 211, no. 8, pp. 610-618. DOI: 10.1016/j.prp.2015.05.005

Absence of nicotinic acetylcholine receptor a7 subunit amplifies inflammation and accelerates onset of fibrosis: An inflammatory kidney model
Truong, LD, Trostel, J & Garcia, GE 2015, FASEB Journal, vol 29, no. 8, pp. 3558-3570. DOI: 10.1096/fj.14-262493

Kidney injury associated with telavancin dosing regimen in an animal model
Tam, VH, Ledesma, KR, Bowers, DR, Zhou, J & Truong, LD 2015, Antimicrobial Agents and Chemotherapy, vol 59, no. 5, pp. 2930-2933. DOI: 10.1128/AAC.05002-14

Loss of PTEN promotes podocyte cytoskeletal rearrangement, aggravating diabetic nephropathy
Lin, JS, Shi, Y, Peng, H, Shen, X, Thomas, S, Wang, Y, Truong, LD, Dryer, SE, Hu, Z & Xu, J 2015, Journal of Pathology, vol 236, no. 1, pp. 30-40. DOI: 10.1002/path.4508

Lymphatic endothelial cancerization in papillary thyroid carcinoma: Hidden evidence of lymphatic invasion
Mai, KT, Truong, LD, Ball, CG, Olberg, B, Lai, CK & Purgina, B 2015, Pathology International, vol 65, no. 5, pp. 220-230. DOI: 10.1111/pin.12272

Membranous nephropathy in autologous hematopoietic stem cell transplant: Autologous graft-versus-host disease or autoimmunity induction?
Abudayyeh, A, Truong, LD, Beck, LH, Weber, DM, Rezvani, K & Abdelrahim, M 2015, Clinical Kidney Journal, vol 8, no. 4, pp. 440-444. DOI: 10.1093/ckj/sfv036

AKI after conditional and kidney-specific knockdown of stanniocalcin-1
Huang, L, Belousova, T, Pan, JSC, Du, J, Ju, H, Lu, L, Zhang, P, Truong, LD, Nuotio-Antar, A & Sheikh-Hamad, D 2014, Journal of the American Society of Nephrology, vol 25, no. 10, pp. 2303-2315. DOI: 10.1681/ASN.2013070690

ANCA-mediated crescentic glomerulonephritis with linear deposition of IgG along the glomerular basement membrane.
Sangsiraprapha, W, Truong, L & Mandayam, S 2014, Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, vol 25, no. 3, pp. 634-637.

Diagnostic utility of E-cadherin and P120 catenin cocktail immunostain in distinguishing DCIS from LCIS
Li, X, Schwartz, MR, Ro, J, Hamilton, CR, Ayala, AG, Truong, LD & Zhai, QJ 2014, International Journal of Clinical and Experimental Pathology, vol 7, no. 5, pp. 2551-2557.

Tubulointerstitial nephritis in systemic lupus erythematosus: Innocent bystander or ominous presage
Dhingra, S, Qureshi, R, Abdellatif, A, Gaber, LW & Truong, LD 2014, Histology and Histopathology, vol 29, no. 5, pp. 553-565.

An evaluation of Congo red fluorescence for the diagnosis of amyloidosis
Clement, CG & Truong, LD 2014, Human Pathology, vol 45, no. 8, pp. 1766-1772. DOI: 10.1016/j.humpath.2014.04.016