Luan Truong, MD

Professor of Pathology and Genomic Medicine, Institute for Academic Medicine
Full Member, Research Institute
Houston Methodist
Weill Cornell Medical College


After completing his training in renal pathology in 1984, Dr. Truong joined the Department of Pathology at Baylor College of Medicine. He was promoted to Associate Professor in 1990, and Professor in 1996. He currently holds full-time faculty appointment in the Department of Pathology, Weill Medical College of Cornell University and in the Houston Methodist Research Institute. He also hold adjunct faculty appointment in the Departments of Pathology and Medicine, Baylor College of Medicine. He has been the attending pathologist for the Harris County Hospital District and Houton Methodist since 1984, and has served as Chief of Nephropathology since 1989. Dr. Truong also serves as the Director of the Pathology Core for the interdepartmental NIH-funded O’Brien Research Center on Renal Inflammation. Well recognized in the area of nephropathology, Dr. Truong actively participates in scholarly activities in this field as section editor and peer-reviewer for many scientific journals, as leader in professional societies, and as lecturer in national and international scientific meetings. 

Description of Research

Dr. Truong´s research interests involve surgical pathology and nephropathology. In the area of surgical pathology, he is interested in using morphology to define new diseases and to improve the diagnostic accuracy of known diseases. He combines traditional clinicopathologic observation with novel immunohistochemical techniques to study case materials drawn from more than 30,000 surgical pathology specimens submitted to the Department of Pathology and Genomic Medicine annually. In the area of clinical nephropathology, Dr. Truong is interested in assessing the pathogenesis and natural behavior of several specific renal diseases using a clinico-pathologic approach, and has access to more than 10,000 renal biopsies accumulated in the renal pathology laboratory suitable for this purpose. In the area of experimental nephropathology, Dr. Truong’s research focuses on the pathogenesis of primary chronic tubulointerstitial nephritis. He has established a model of chronic obstructive uropathy by unilateral ligation of the ureter and has focused on cell cycle abnormality, including apoptosis and cell proliferation of tubular cells and interstitial cells as a crucial element in chronic tubulointerstitial injury. He is currently investigating preconditioning as a mechanism to attenuate acute tubular cell injury. He recently made the novel observation that activation of cell survival mechanisms, including the PI3 kinase pathway and survivin, may serve as important protective mechanisms. He also collaborates extensively with other investigators in the Texas Medical Center and elsewhere in terms of morphologic support and structure-function correlation studies on various renal diseases.

Areas Of Expertise

Kidney diseases Acute tubular cell injury chronic tubulointerstitial injury Renal transplantation Renal neoplasms
Education & Training

, Baylor College of Medicine
, Pennsylvania State University College of Medicine

MiR-93 regulates Msk2-mediated chromatin remodelling in diabetic nephropathy
Badal, SS, Wang, Y, Long, J, Corcoran, DL, Chang, BH, Truong, LD, Kanwar, YS, Overbeek, PA & Danesh, FR 2016, Nature Communications, vol 7, 12076. DOI:

Characterization of polymyxin B biodistribution and disposition in an animal model
Manchandani, P, Zhou, J, Ledesma, KR, Truong, LD, Chow, DSL, Eriksen, JL & Tam, VH 2016, Antimicrobial Agents and Chemotherapy, vol 60, no. 2, pp. 1029-1034. DOI:

Enigma (partially) resolved: Phospholipase A2 receptor is the cause of “idiopathic” membranous glomerulonephritis
Truong, LD & Seshan, SV 2015, American Journal of Physiology - Renal Physiology, vol 309, no. 12, pp. F1000-F1002. DOI:

Obstructive nephropathy: What the surgical pathologist should know
Truong, L & Mai, K 2015, Pathology Case Reviews, vol 20, no. 6, pp. 250-255. DOI:

Severe nephrotoxic nephritis following conditional and kidney-specific knockdown of stanniocalcin-1
Huang, L, Lou, Y, Ju, H, Zhang, L, Pan, JSC, Ross, A, Sun, Y, Truong, LD & Sheikh-Hamad, D 2015, PLoS ONE, vol 10, no. 9, e0138440. DOI:

Invasive urothelial carcinoma exhibiting basal cell immunohistochemical markers: A variant of urothelial carcinoma associated with aggressive features
Mai, KT, Truong, LD, Ball, CG, Williams, P, Flood, TA & Belanger, EC 2015, Pathology Research and Practice, vol 211, no. 8, pp. 610-618. DOI:

Absence of nicotinic acetylcholine receptor a7 subunit amplifies inflammation and accelerates onset of fibrosis: An inflammatory kidney model
Truong, LD, Trostel, J & Garcia, GE 2015, FASEB Journal, vol 29, no. 8, pp. 3558-3570. DOI:

Invasive urothelial carcinoma exhibiting basal cell immunohistochemical markers: A variant of urothelial carcinoma associated with aggressive features
Mai, KT, Truong, LD, Ball, CG, Williams, P, Flood, TA & Belanger, EC 2015, Pathology Research and Practice, vol 211, no. 8, pp. 610-618. DOI:

Kidney injury associated with telavancin dosing regimen in an animal model
Tam, VH, Ledesma, KR, Bowers, DR, Zhou, J & Truong, LD 2015, Antimicrobial Agents and Chemotherapy, vol 59, no. 5, pp. 2930-2933. DOI:

Loss of PTEN promotes podocyte cytoskeletal rearrangement, aggravating diabetic nephropathy
Lin, JS, Shi, Y, Peng, H, Shen, X, Thomas, S, Wang, Y, Truong, LD, Dryer, SE, Hu, Z & Xu, J 2015, Journal of Pathology, vol 236, no. 1, pp. 30-40. DOI:

Lymphatic endothelial cancerization in papillary thyroid carcinoma: Hidden evidence of lymphatic invasion
Mai, KT, Truong, LD, Ball, CG, Olberg, B, Lai, CK & Purgina, B 2015, Pathology International, vol 65, no. 5, pp. 220-230. DOI:

Membranous nephropathy in autologous hematopoietic stem cell transplant: Autologous graft-versus-host disease or autoimmunity induction?
Abudayyeh, A, Truong, LD, Beck, LH, Weber, DM, Rezvani, K & Abdelrahim, M 2015, Clinical Kidney Journal, vol 8, no. 4, pp. 440-444. DOI:

AKI after conditional and kidney-specific knockdown of stanniocalcin-1
Huang, L, Belousova, T, Pan, JSC, Du, J, Ju, H, Lu, L, Zhang, P, Truong, LD, Nuotio-Antar, A & Sheikh-Hamad, D 2014, Journal of the American Society of Nephrology, vol 25, no. 10, pp. 2303-2315. DOI:

Intraoperative frozen section evaluation of ureteral and urethral margins: studies of 203 consecutive radical cystoprostatectomy for men with bladder urothelial carcinoma
Zhou, H, Ro, JY, Truong, LD, Ayala, AG & Shen, SS 2014, American Journal of Clinical and Experimental Urology, vol 2, no. 2, pp. 156-60.

Haemangiomas in kidneys with end-stage renal disease: A novel clinicopathological association
Kryvenko, ON, Haley, SL, Smith, SC, Shen, SS, Paluru, S, Gupta, NS, Jorda, M, Epstein, JI, Amin, MB & Truong, LD 2014, Histopathology, vol 65, no. 3, pp. 309-318. DOI:

Fine-needle aspiration of the kidney and adrenal gland
Gorman, BK , Truong, LD & Anton, R 2014, . in Differential Diagnosis in Cytopathology. Cambridge University Press, pp. 566-616. DOI:

PAX2 and PAX8: Useful markers for metastatic effusions
Waters, L, Crumley, S, Truong, L, Mody, D & Coffey, D 2014, Acta Cytologica, vol 58, no. 1, pp. 60-66. DOI:

ANCA-mediated crescentic glomerulonephritis with linear deposition of IgG along the glomerular basement membrane.
Sangsiraprapha, W, Truong, L & Mandayam, S 2014, Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, vol 25, no. 3, pp. 634-637.

Diagnostic utility of E-cadherin and P120 catenin cocktail immunostain in distinguishing DCIS from LCIS
Li, X, Schwartz, MR, Ro, J, Hamilton, CR, Ayala, AG, Truong, LD & Zhai, QJ 2014, International Journal of Clinical and Experimental Pathology, vol 7, no. 5, pp. 2551-2557.

Tubulointerstitial nephritis in systemic lupus erythematosus: Innocent bystander or ominous presage
Dhingra, S, Qureshi, R, Abdellatif, A, Gaber, LW & Truong, LD 2014, Histology and Histopathology, vol 29, no. 5, pp. 553-565.